39 research outputs found

    Preliminary assessment of fluorine-18 fluorodeoxyglucose positron mission tomography in patients with bladder cancer

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    The purpose of this study was to assess the feasibility of imaging of bladder cancer with fluorine-18 fluorodeoxyglucose positron emission tomography (FDG-PET) scanning. We studied 12 patients with histologically proven bladder cancer who had undergone surgical procedures and/or radiotherapy. Retrograde irrigation of the urinary bladder with 1000–3710 ml saline was performed during nine of the studies. Dynamic and static PET images were obtained, and standardized uptake value images were reconstructed. FDG-PET scanning was true-positive in eight patients (66.7%), but false-negative in four (33.3%). Of 20 organs with tumor mass lesions confirmed pathologically or clinically, 16 (80%) were detected by FDG-PET scanning. FDG-PET scanning detected all of 17 distant metastatic lesions and two of three proven regional lymph node metastases. FDG-PET was also capable of differentiating viable recurrent bladder cancer from radiation-induced alterations in two patients. In conclusion, these preliminary data indicate the feasibility of FDG-PET imaging in patients with bladder cancer, although a major remaining pitfall is intense FDG accumulation in the urine.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/46842/1/259_2004_Article_BF00841398.pd

    Bench-scale centrifuge testing to determine the hydraulic conductivity of clayey soils

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    The purpose of this research is to validate a mathematical model for flow through saturated and unsaturated porous media using a bench-scale centrifuge for an accurate determination of the hydraulic conductivity (function of the saturation degree of a soil) within a limited time at a reasonable price. The aim of this paper is to show preliminary results of this investigation where the validation and calibration of the mathematical model is performed determining the hydraulic conductivity of saturated porous media, such as kaolin clay and glass porous filters, with a bench-scale centrifuge
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