201 research outputs found
Measuring Gravito-magnetic Effects by Multi Ring-Laser Gyroscope
We propose an under-ground experiment to detect the general relativistic
effects due to the curvature of space-time around the Earth (de Sitter effect)
and to rotation of the planet (dragging of the inertial frames or
Lense-Thirring effect). It is based on the comparison between the IERS value of
the Earth rotation vector and corresponding measurements obtained by a
tri-axial laser detector of rotation. The proposed detector consists of six
large ring-lasers arranged along three orthogonal axes.
In about two years of data taking, the 1% sensitivity required for the
measurement of the Lense-Thirring drag can be reached with square rings of 6
side, assuming a shot noise limited sensitivity ().
The multi-gyros system, composed of rings whose planes are perpendicular to one
or the other of three orthogonal axes, can be built in several ways. Here, we
consider cubic and octahedron structures. The symmetries of the proposed
configurations provide mathematical relations that can be used to study the
stability of the scale factors, the relative orientations or the ring-laser
planes, very important to get rid of systematics in long-term measurements,
which are required in order to determine the relativistic effects.Comment: 24 pages, 26 Postscript figure
Frequency and Nature of Incidental Extra-Enteric Lesions Found on Magnetic Resonance Enterography (MR-E) in Patients with Inflammatory Bowel Diseases (IBD)
The aim of this study was to determine the occurrence of extra-enteric findings in a large cohort of patients undergoing magnetic resonance enterography (MR-E) and to classify the clinical significance of these findings.We retrospectively analyzed 1154 MR-E performed in 1006 patients referred to our radiological department between 1999-2005. The reasons for referral were suspected or proven inflammatory bowel diseases (IBD) (n = 710), further diagnostic work-up for small bowel disease because of non-specific abdominal symptoms (SBD; n = 182) or suspected small bowel malignancies (SBM; n = 114). All extra-enteric findings were reviewed by a radiologist and a gastroenterologist and were classified as having high, moderate, or low significance for further diagnostic or therapeutic procedures.The average age of all patients was 40+/-16 (Mean+/-SD) years (y) (IBD 35+/-13 y; SBD 49+/-16 y; SBM 57+/-15 y). A total of 1113 extra-enteric findings were detected in 600 of 1006 patients (59.6%). Of these findings 180 (16.2%) were judged as having a high, 212 (19.0%) a moderate and 721 (64.8%) a low significance. On a per group basis in patients with IBD 12.0% of the findings were of major clinical significance compared to 13.7% and 33.3% in patients with SBD and SBM, respectively. The most common major findings were abscesses (69.9%) in the IBD group and extraintestinal tumors, metastases or masses in the SBD and SBM groups (41.9% and 74.2%, respectively).MR-E reveals a substantial number of extra-enteric findings, supporting the role of a cross-sectional imaging method for the evaluation of the small bowel
Dust in the Small Magellanic Cloud: Interstellar Polarization and Extinction
To elucidate the dust properties in the SMC we have for the first time
measured linear polarization in five colors in the optical region of the
spectrum for a sample of reddened stars. For two of these stars, for which
there were no existing UV spectrophotometric measurements, but for which we
measured a relatively large polarization, we have also obtained data from the
International Ultraviolet Explorer (IUE) in order to study the extinction. The
main results are: (1) the wavelength of maximum polarization, ,
in the SMC is typically smaller than that in the Galaxy; (2) however, AZV 456,
which shows the UV extinction bump, has a typical of that in
the Galaxy, its polarization curve is narrower, its bump is shifted to shorter
wavelengths as compared to the Galaxy and its UV extinction does not conform to
the Galactic analytical interpolation curve based on the ratio of total to
selective extinction; (3) the 'typical', monotonic SMC extinction curve can be
best fit with amorphous carbon and silicate grains; (4) the extinction towards
AZV456 may only be explained by assuming a larger gas-to-dust ratio than the
observed N(HI)/A(V) value, with a small amount of the available carbon in
graphite form; (5) from an analysis of both the extinction and polarization
data and our model fits it appears that the SMC has typically smaller grains
than those in the Galaxy.Comment: To appear in the ApJ, 50 pages, latex fil
Phosphorylation controls autoinhibition of cytoplasmic linker protein-170
Author Posting. © American Society for Cell Biology, 2010. This article is posted here by permission of American Society for Cell Biology for personal use, not for redistribution. The definitive version was published in Molecular Biology of the Cell 21 (2010): 2661-2673, doi:10.1091/mbc.E09-12-1036.Cytoplasmic linker protein (CLIP)-170 is a microtubule (MT) plus-end-tracking protein that regulates MT dynamics and links MT plus ends to different intracellular structures. We have shown previously that intramolecular association between the N and C termini results in autoinhibition of CLIP-170, thus altering its binding to MTs and the dynactin subunit p150Glued (J. Cell Biol. 2004: 166, 1003–1014). In this study, we demonstrate that conformational changes in CLIP-170 are regulated by phosphorylation that enhances the affinity between the N- and C-terminal domains. By using site-directed mutagenesis and phosphoproteomic analysis, we mapped the phosphorylation sites in the third serine-rich region of CLIP-170. A phosphorylation-deficient mutant of CLIP-170 displays an "open" conformation and a higher binding affinity for growing MT ends and p150Glued as compared with nonmutated protein, whereas a phosphomimetic mutant confined to the "folded back" conformation shows decreased MT association and does not interact with p150Glued. We conclude that phosphorylation regulates CLIP-170 conformational changes resulting in its autoinhibition.This work was supported by National
Institutes of Health grant GM-25062 (to G.G.B.); Netherlands Organization for
Scientific Research grants (to A. A. and N. G.); a Cancer Genomics Centre
grant (to J.v.H.); and Presidential Program of Russian Academy of Sciences
and RFBP grant 05-04-4915 (to E.S.N.)
Food, flavouring and feed plant traditions in the Tyrrhenian sector of Basilicata, Italy
BACKGROUND: Research was carried out in the years 2002–2003 into food, flavouring and feed folk traditions of plants in the Tyrrhenian part of the Basilicata region (southern Italy). This area was colonized in ancient times by Greeks. Data was collected through field interviews, especially of farmers. METHODS: Field data were collected through structured interviews. The informants, numbered 49, belonged to families which had strong links with the traditional activities of the area. RESULTS: 61 taxa are cited, belonging to 26 botanical families, amongst which 44 used as food or flavouring and 22 for animal alimentation. Besides 7 taxa are involved in rituals especially connected with agriculture and plant growth. CONCLUSION: The preservation of some rituals especially concerning agricultural plants is noteworthy in the area, together with a certain degree of continuity in food uses. Knowledge and rediscovery of recipes in human and animal diet could represent an economic potential for the area
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