38 research outputs found
Therapeutic effect of nanoparticles depends on growth parameters.
<p>Four different populations of calcium-based nanoparticles (NPs) were synthesized (represented as NP 1 through NP 4). For each population, the concentration of calcium chloride and glycerol phosphate were varied in the coating material. NP 1: collagen (0.5 mg/ml). NP 2: collagen (0.5 mg/ml) + beta-glycerophosphate (5 mM). NP 3: collagen (0.5 mg/ml) + CaCl<sub>2</sub> (2 mM). NP 4: collagen (0.5 mg/ml) + beta-glycerophosphate (5 mM) + CaCl<sub>2.</sub> These different nanoparticle populations were injected through the tail vein of wounded mice, and the rate of wound healing was assessed for each group. Each nanoparticle population had a different effect on wound healing. P-values were calculated using the Dunnett's test. The data is expressed as the mean ± SD.</p
The ionic composition of calcium-based nanoparticles.
<p>SEM/EDX analysis demonstrates the ionic composition of our calcium-based nanoparticles. These nanoparticles represent a collection of charged ions including oxygen, sodium, silica, phosphorous, potassium, and calcium. The predominant ions are calcium, oxygen, and phosphate. Note: Ka represents the energy yield from the L → K electronic orbital transition and Kb represents the energy yield from the M → K electronic orbital transition.</p
Calcium-based nanoparticle treatment increases fibroblast calcium uptake.
<p>Fibroblasts in culture showed increased calcium uptake in a dose dependent manner after calcium-based nanoparticle treatment. P-values were calculated using the Dunnett's test. The data is expressed as the mean ± SD.</p
Topical administration of calcium-based nanoparticles does not accelerate wound healing.
<p>Wounded mice received a topical application of either calcium chloride, calcium-based nanoparticles (CNPs) or saline. Topically applied calcium-based nanoparticles did not enhance wound healing. However, topically applied calcium chloride significantly increased the rate of wound healing relative to controls. P-values were calculated using the Dunnett's test. The data is expressed as the mean ± SD.</p