405 research outputs found

    Cannabinoid ligands, receptors and enzymes: pharmacological tools and therapeutic potential

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    Endocannabinoids have been identified to have roles in numerous physiological and pathological processes. Largely due to the association of the effects of Cannabis administration on mental states, the CNS impact of the endocannabinoid system has been the most intensively studied. Here, we provide a brief summary of the endocannabinoid system, comprising the receptors and the multiple endogenous lipid derivatives which activate them, as well as the enzymes which control the levels of these lipid derivatives. We identify pharmacological tools which may be used to interrogate the endocannabinoid system, as well as current and future options to exploit the system in the clinic

    Hepatitis B surface antigen in urine of hemodialysis patients

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    Hepatitis B surface antigen in urine of hemodialysis patients. As part of an extensive epidemiological survey of chronic hemodialysis patients in Michigan, hepatitis B surface antigen (HBsAg) was identified in the sera of 79 of 701 (11%) patients. Of these patients, 59 were carriers of HBsAg for three or more months. Urine samples were collected from 36 of 39 HBsAg carriers having urinary output. Of these samples, 19 (52%) were positive for HBsAg by radioimmunoassay; this was confirmed by specific antibody neutralization. The HBsAg was not identified in the urine of seven hemodialysis patients who were lacking serum HBsAg or in urine samples from three HBsAg sero-carriers who had normal renal function. Patients undergoing maintenance hemodialysis appear to constitute a large reservoir of HBsAg chronic carriers. This study indicates that a minimum of 50% of persistent HBsAg carriers who are producing urine have detectable. HBsAg in single, randomly timed, unconcentrated urine specimen. These data suggest that urine may represent a potential vehicle for transmission in nonparenterally acquired hepatitis B.Antigène de surface de l'hépatite B dans l'urine de malades en hémodialyse. Dans le cadre d'une large enquête épidémiologique à propos des malades en hémodialyse chronique dans le Michigan, l'antigène de surface de l'hépatite B (HBsAg) a été identifié dans le sérum de 79 parmi 701 malades (11%). Parmi ces malades, 59 étaient des porteurs de HBsAg depuis 3 mois ou plus. L'urine de 36 des 39 porteurs de HBsAg, qui avaient une diurèse, a été recueillie. Parmi ces 36 urines, 19 (52%) sont positives pour HBsAg par radio-immunologie, ce qui est confirmé par la neutralisation au moyen d'anticorps spécifique. Le HBsAg n'apas été identifié dans l'urine de 7 malades en hémodialyse qui n'avaient pas le HBsAg sérique et dans l'urine de 3 porteurs de HBsAg dont les fonctions rénales étaient normales. Les malades soumis à l'hémodialyse itérative paraissent constituer un grand réservoir de porteurs chroniques de HBsAg. Cette étude indique qu'au minimum 50% des porteurs chroniques de HBsAg qui ont une diurèse, ont un HBsAg détectable dans un échantillon unique d'urine, prélevé au hasard, non concentré. Ces résultats suggèrent que l'urine peut être un véhicule de transmission de l'hépatite B acquise par voie non parentérale

    A Preliminary study of removal of some heavy metals from aqueous medium by a mesoporous hydroxysodalite zeolite prepared from basalt rich in calc-plagioclaseby alkali activation

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    This work presents an exploration of the use of hydroxysodalite zeolite prepared from basalt rich in calc-plagioclaseby alkali activation for removal of some heavy metals from aqueous medium. The preliminary results of batch and column experiments indicated a quantitative and fast removal of the three investigated ions, Cu2+, Pb2+ and Zn2+ from aqueous solutions. The data from the batch experiments and the column experiments jointly support the notion that hydroxysodalite zeolite prepared from basalt rich in calc-plagioclase is an efficient adsorbent for the investigated heavy metals.  Almost quantitative removal of the ions was achieved within a period of 15 min of exposure of the solution to the adsorbent in batch experiments and through passing a small column filled with the adsorbent. The highest removal efficiency  by the zeolite prepared from basalt rich in calc-plagioclase of  the three tested heavy metal Cu2+, Pb2+ and Zn2+ were 99.98% ,99.76% and 99.93 % respectively. Keywords: hydroxysodalite zeolite, basalt utilization, heavy ions removal, pollution  remediation DOI: 10.7176/CMR/12-7-09 Publication date:November 30th 2020

    Effect of Age and Lordotic Angle on the Level of Lumbar Disc Herniation

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    It has been previously suggested in the literature that with aging, degenerative changes as well as disc herniation start at the lower lumbar segments, with higher disc involvement observed in an ascending fashion in older age groups. We conducted a study to investigate this correlation between age and level of disc herniation, and to associate it with the magnitude of the Lumbar Lordotic Angle (LLA), as measured by Cobb's method. We followed retrospectively lumbosacral spine MRI's of 1419 patients with symptomatic disc herniation. Pearson's correlation was used in order to investigate the relationship between LLA, age, and level of disc herniation. Student's t-test was applied to assess gender differences. Young patients were found to have higher LLA (R = 0.44, P < 0.0001) and lower levels of disc herniation (R = 0.302, P < 0.0001), whereas older patients had higher level herniation in lower LLA group (mean LLA 28.6° and 25.4°) and lower level herniation in high LLA group (mean LLA 33.2°). We concluded that Lumbar lordotic Cobb's angle and age can be predictors of the level of lumbar disc herniation. This did not differ among men and women (R = 0.341, P < 0.0001)

    A Survey of Air-to-Ground Propagation Channel Modeling for Unmanned Aerial Vehicles

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    In recent years, there has been a dramatic increase in the use of unmanned aerial vehicles (UAVs), particularly for small UAVs, due to their affordable prices, ease of availability, and ease of operability. Existing and future applications of UAVs include remote surveillance and monitoring, relief operations, package delivery, and communication backhaul infrastructure. Additionally, UAVs are envisioned as an important component of 5G wireless technology and beyond. The unique application scenarios for UAVs necessitate accurate air-to-ground (AG) propagation channel models for designing and evaluating UAV communication links for control/non-payload as well as payload data transmissions. These AG propagation models have not been investigated in detail when compared to terrestrial propagation models. In this paper, a comprehensive survey is provided on available AG channel measurement campaigns, large and small scale fading channel models, their limitations, and future research directions for UAV communication scenarios

    Mapping research activity on mental health disorders in Europe: Study protocol for the Mapping_NCD project

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    © 2016 The Author(s). Background: Mental health disorders (MHDs) constitute a large and growing disease burden in Europe, although they typically receive less attention and research funding than other non-communicable diseases (NCDs). This study protocol describes a methodology for the mapping of MHD research in Europe as part of Mapping_NCD, a 2-year project funded by the European Commission which seeks to map European research funding and impact for five NCDs in order to identify potential gaps, overlaps, synergies and opportunities, and to develop evidence-based policies for future research. Methods: The project aims to develop a multi-focal view of the MHD research landscape across the 28 European Union Member States, plus Iceland, Norway and Switzerland, through a survey of European funding entities, analysis of research initiatives undertaken in the public, voluntary/not-for-profit and commercial sectors, and expert interviews to contextualize the gathered data. The impact of MHD research will be explored using bibliometric analyses of scientific publications, clinical guidelines and newspaper stories reporting on research initiatives. Finally, these research inputs and outputs will be considered in light of various metrics that have been proposed to inform priorities for the allocation of research funds, including burden of disease, treatment gaps and cost of illness. Discussion: Given the growing burden of MHDs, a clear and broad view of the current state of MHD research is needed to ensure that limited resources are directed to evidence-based priority areas. MHDs pose a particular challenge in mapping the research landscape due to their complex nature, high co-morbidity and varying diagnostic criteria. Undertaking such an effort across 31 countries is further challenged by differences in data collection, healthcare systems, reimbursement rates and clinical practices, as well as cultural and socioeconomic diversity. Using multiple methods to explore the spectrum of MHD research funding activity across Europe, this project aims to develop a broad, high-level perspective to inform priority setting for future research

    A new hereditary colorectal cancer network in the Middle East and eastern mediterranean countries to improve care for high-risk families

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    Colorectal cancer (CRC) has a very high incidence in the western world. Data from registries in the Middle East showed that the incidence of CRC is relatively low in these countries. However, these data also showed that CRC incidence has increased substantially over the past three decades and that a high proportion of cases are diagnosed at an early age (<50 years). In view of these findings, more attention should be paid to prevention. Because of the often limited financial resources, focused screening of individuals with hereditary CRC, in particular those with Lynch syndrome, appears to be the most cost-effective strategy. During recent meetings of the Palestinian Society of Gastroenterology and the Mediterranean Task force for Cancer Control (MTCC) in Jericho, and the Patient�s Friends Society of Jerusalem in Hebron the issue of hereditary CRC in the Middle East was discussed and the idea was conceived to establish a network on hereditary colorectal cancer (HCCN-ME) with the goal of improving care for high-risk groups in the Middle East and (Eastern) Mediterranean Countries. © 2017, The Author(s)

    Erratum to: A new hereditary colorectal cancer network in the Middle East and eastern Mediterranean countries to improve care for high-risk families (Familial Cancer, (2018), 17, 2, (209-212), 10.1007/s10689-017-0018-6)

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    Unfortunately, the 10th author name in the author group was published incorrectly in the original publication as �Keivan Maijdzadeh� the correct name is: Keivan Majidzadeh.Author name has also been corrected in the original publication. © Springer Science+Business Media B.V. 2017
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