324 research outputs found

    PMS67 HEALTH GAINS FOREGONE DUETO THE SUSTAINED DELAY OF ADEQUATE UTILIZATION OF EVIDENCE BASED TREATMENTS: THE CASE OF BISPHOSPHONATES FOR THE TREATMENT OF OSTEOPOROSIS

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    PMD30 MODELLING OF PREVALENCE, COSTS AND OUTCOME OF ACID-RELATED DISORDERS USING CLAIMS DATA

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    Methods for Lightweight Design of Mechanical Components in Humanoid Robots

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    POB4 USING CLAIMS DATA TO UNDERSTAND THE COSTS OF DIFFERENT HEALTH STATES FOR PATIENTS WITH CARDIOMETABOLIC RISK

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    Non-equilibrium electronic transport and interaction in short metallic nanobridges

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    We have observed interaction effects in the differential conductance GG of short, disordered metal bridges in a well-controlled non-equilibrium situation, where the distribution function has a double Fermi step. A logarithmic scaling law is found both for the temperature and for the voltage dependence of GG in all samples. The absence of magnetic field dependence and the low dimensionality of our samples allow us to distinguish between several possible interaction effects, proposed recently in nanoscopic samples. The universal scaling curve is explained quantitatively by the theory of electron-electron interaction in diffusive metals, adapted to the present case, where the sample size is smaller than the thermal diffusion length.Comment: Published version, 6 Pages, 6 postscript figures, 1 tabl

    Nonequilibrium coupled Brownian phase oscillators

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    A model of globally coupled phase oscillators under equilibrium (driven by Gaussian white noise) and nonequilibrium (driven by symmetric dichotomic fluctuations) is studied. For the equilibrium system, the mean-field state equation takes a simple form and the stability of its solution is examined in the full space of order parameters. For the nonequilbrium system, various asymptotic regimes are obtained in a closed analytical form. In a general case, the corresponding master equations are solved numerically. Moreover, the Monte-Carlo simulations of the coupled set of Langevin equations of motion is performed. The phase diagram of the nonequilibrium system is presented. For the long time limit, we have found four regimes. Three of them can be obtained from the mean-field theory. One of them, the oscillating regime, cannot be predicted by the mean-field method and has been detected in the Monte-Carlo numerical experiments.Comment: 9 pages 8 figure

    Bar Evolution Over the Last Eight Billion Years: A Constant Fraction of Strong Bars in GEMS

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    One third of present-day spirals host optically visible strong bars that drive their dynamical evolution. However, the fundamental question of how bars evolve over cosmological times has yet to be addressed, and even the frequency of bars at intermediate redshifts remains controversial. We investigate the frequency of bars out to z~1.0 drawing on a sample of 1590 galaxies from the GEMS survey, which provides morphologies from HST ACS two-color images, and highly accurate redshifts from the COMBO-17 survey. We identify spiral galaxies using the Sersic index, concentration parameter, and rest-frame color. We characterize bars and disks by fitting ellipses to F606W and F850LP images, taking advantage of the two bands to minimize bandpass shifting. We exclude highly inclined (i>60 deg) galaxies to ensure reliable morphological classifications, and apply completeness cuts of M_v <= -19.3 and -20.6. More than 40% of the bars that we detect have semi major axes a<0.5" and would be easily missed in earlier surveys without the small PSF of ACS. The bars that we can reliably detect are fairly strong (with ellipticities e>=0.4) and have a in the range ~1.2-13 kpc. We find that the optical fraction of such strong bars remains at ~(30% +- 6%) from the present-day out to look-back times of 2-6 Gyr (z~0.2-0.7) and 6-8 Gyr (z~0.7-1.0); it certainly shows no sign of a drastic decline at z>0.7. Our findings of a large and similar bar fraction at these three epochs favor scenarios in which cold gravitationally unstable disks are already in place by z~1, and where on average bars have a long lifetime (well above 2 Gyr). The distributions of structural bar properties in the two slices are, however, not statistically identical and therefore allow for the possibility that the bar strengths and sizes may evolve over time.Comment: Accepted by ApJ Letters, to appear in Nov 2004 issue. Minor revisions,updated reference

    Short communication: Circulating and milk adiponectin change differently during energy deficiency at different stages of lactation in dairy cows

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    Adiponectin, one of the most abundant adipokines in circulation, is known for its role in regulation of body metabolism. The aim of this study was to evaluate the effects of a negative energy balance (NEB) at 2 stages of lactation (lactational NEB at the onset of lactation and an induced NEB by feed restriction near 100 d of lactation) on circulating adiponectin concentrations. We also investigated the effect of feed restriction on adiponectin concentrations in milk and the relationships of blood and milk adiponectin with selected plasma or milk variables and with measures of body condition. Plasma adiponectin was measured in 50 multiparous Holstein dairy cows throughout 3 experimental periods [i.e., period 1=3 wk antepartum up to 12 wk postpartum, period 2=3 wk of feed restriction starting at around 100 d in milk with a control (n=25) and feed-restricted group (50% of energy requirements; n=25), and period 3=subsequent realimentation period for 8 wk]. Milk adiponectin was investigated among 21 multiparous cows at wk 2 and wk 12 of period 1 and wk 2 of period 2. Adiponectin concentrations in plasma and skim milk were measured using an in-house ELISA specific for bovine adiponectin. Major changes in circulating adiponectin concentrations were observed during the periparturient period, whereas energy deficiency during established lactation at around 100 d in milk and subsequent refeeding did not affect plasma adiponectin. Together with lower adiponectin concentrations in milk (”g/mL), the reduction in milk yield led to decreased adiponectin secretion via milk (mg/d) at the second week of feed restriction. Irrespective of time and treatment, milk adiponectin represented about 0.002% of total milk protein. Mean adiponectin concentrations in milk (0.61 ± 0.03 ”g/mL) were about 92% lower than the mean plasma adiponectin concentrations (32.1 ± 1.0 ”g/mL). The proportion of the steady-state plasma adiponectin pool secreted daily via milk was 2.7%. In view of the similar extent of NEB in both periods of energy deficiency, decreasing adiponectin concentrations seems important for accomplishing the adaptation to the rapidly increasing metabolic rates in early lactation, whereas the lipolytic reaction toward feed restriction-induced NEB during established lactation seems to occur largely independent of changes in circulating adiponectin
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