Physical Characteristics of the Spectral States of Galactic Black Holes

Using simple analytical estimates we show how the physical parameters characterizing different spectral states of the galactic black hole candidates can be determined using spectral data presently available.Comment: 5 pages, 3 figures, to appear in the Proceedings of 4th Compton Symposium, April 27-30, 1997, Williamsburg, Virginia, US

Expected budget deficits and interest rate swap spreads - Evidence for France, Germany and Italy

This study analyses whether expected budget deficits have an impact on interest rate swap spreads in France, Germany and Italy. We use monthly deficit forecasts from financial market participants to take the forward-looking behaviour of financial markets into account. Results of a SUR estimation show no significant impact of expected deficits on swap spreads over the whole sample period (1994-2004). However, we find an increase in market discipline for Germany and France since the signing of the Stability and Growth Pact, and for Germany also since the start of European monetary union. --Budget deficits,interest rate swap spreads,EMU,Stability and Growth Pact

Stochastic Database Cracking: Towards Robust Adaptive Indexing in Main-Memory Column-Stores

Modern business applications and scientific databases call for inherently dynamic data storage environments. Such environments are characterized by two challenging features: (a) they have little idle system time to devote on physical design; and (b) there is little, if any, a priori workload knowledge, while the query and data workload keeps changing dynamically. In such environments, traditional approaches to index building and maintenance cannot apply. Database cracking has been proposed as a solution that allows on-the-fly physical data reorganization, as a collateral effect of query processing. Cracking aims to continuously and automatically adapt indexes to the workload at hand, without human intervention. Indexes are built incrementally, adaptively, and on demand. Nevertheless, as we show, existing adaptive indexing methods fail to deliver workload-robustness; they perform much better with random workloads than with others. This frailty derives from the inelasticity with which these approaches interpret each query as a hint on how data should be stored. Current cracking schemes blindly reorganize the data within each query's range, even if that results into successive expensive operations with minimal indexing benefit. In this paper, we introduce stochastic cracking, a significantly more resilient approach to adaptive indexing. Stochastic cracking also uses each query as a hint on how to reorganize data, but not blindly so; it gains resilience and avoids performance bottlenecks by deliberately applying certain arbitrary choices in its decision-making. Thereby, we bring adaptive indexing forward to a mature formulation that confers the workload-robustness previous approaches lacked. Our extensive experimental study verifies that stochastic cracking maintains the desired properties of original database cracking while at the same time it performs well with diverse realistic workloads.Comment: VLDB201

Quantum Transport through Nanostructures with Orbital Degeneracies

Geometric symmetries cause orbital degeneracies in a molecule's spectrum. In a single-molecule junction, these degeneracies are lifted by various symmetry-breaking effects. We study quantum transport through such nanostructures with an almost degenerate spectrum. We show that the master equation for the reduced density matrix must be derived within the singular-coupling limit as opposed to the conventional weak-coupling limit. This results in signatures of the density matrix's off-diagonal elements in the transport characteristics

Collective synchronization in populations of globally coupled phase oscillators with drifting frequencies

We generalize the Kuramoto model for coupled phase oscillators by allowing the frequencies to drift in time according to Ornstein-Uhlenbeck dynamics. Such drifting frequencies were recently measured in cellular populations of circadian oscillator and inspired our work. Linear stability analysis of the Fokker-Planck equation for an infinite population is amenable to exact solution and we show that the incoherent state is unstable passed a critical coupling strength K_c(\ga, \sigf), where \ga is the inverse characteristic drifting time and \sigf the asymptotic frequency dispersion. Expectedly $K_c$ agrees with the noisy Kuramoto model in the large \ga (Schmolukowski) limit but increases slower as \ga decreases. Asymptotic expansion of the solution for \ga\to 0 shows that the noiseless Kuramoto model with Gaussian frequency distribution is recovered in that limit. Thus varying a single parameter allows to interpolate smoothly between two regimes: one dominated by the frequency dispersion and the other by phase diffusion.Comment: 5 pages, 5 figures, accepted in Phys. Rev.

Pro-Secretory Activity and Pharmacology in Rabbits of an Aminophenyl-1,3,5-Triazine CFTR Activator for Dry Eye Disorders.

PurposePharmacological activation of ocular surface cystic fibrosis transmembrane conductance regulator (CFTR) chloride channels is a potential pro-secretory approach to treat dry eye disorders. We previously reported the discovery of aminophenyl-1,3,5-triazines, one of which, N-methyl-N-phenyl-6-(2,2,3,3-tetrafluoropropoxy)-1,3,5-triazine-2,4-diamine (herein called CFTRact-K267), fully activated human wildtype CFTR with EC50 ∼ 30 nM and increased tear volume for 8 hours in mice. Here, functional and pharmacological studies of CFTRact-K267 were done in adult New Zealand white rabbits.MethodsCFTR chloride conductance was measured in vivo by ocular surface potential differences and in ex vivo conjunctiva by short-circuit current. Tear volume was measured by the Schirmer tear test II and CFTRact-K267 pharmacokinetics and tissue distribution by liquid chromatography/mass spectrometry. Toxicity profile was studied for 28 days with twice-daily topical administration.ResultsElectrophysiological measurements in vivo and in ex vivo conjunctiva demonstrated CFTR activation by CFTRact-K267. A single topical dose of 3 nmol CFTRact-K267 increased tear production by >5 mm for 9 hours by the Schirmer tear test, with predicted therapeutic concentrations maintained in tear fluid. No tachyphylaxis was seen following 28-day twice-daily administration, and changes were not observed in corneal surface integrity or thickness, intraocular pressure, or ocular histology. At day 28, CFTRact-K267 was concentrated in the cornea and conjunctiva and was not detectable in blood or peripheral organs.ConclusionsThese studies support the development of CFTRact-K267 as a pro-secretory therapy for dry eye disorders

Charting the circuit QED design landscape using optimal control theory

With recent improvements in coherence times, superconducting transmon qubits have become a promising platform for quantum computing. They can be flexibly engineered over a wide range of parameters, but also require us to identify an efficient operating regime. Using state-of-the-art quantum optimal control techniques, we exhaustively explore the landscape for creation and removal of entanglement over a wide range of design parameters. We identify an optimal operating region outside of the usually considered strongly dispersive regime, where multiple sources of entanglement interfere simultaneously, which we name the quasi-dispersive straddling qutrits (QuaDiSQ) regime. At a chosen point in this region, a universal gate set is realized by applying microwave fields for gate durations of 50 ns, with errors approaching the limit of intrinsic transmon coherence. Our systematic quantum optimal control approach is easily adapted to explore the parameter landscape of other quantum technology platforms.Comment: 13 pages, 5 figures, 2 pages supplementary, 1 supplementary figur

simpcomp -- A GAP toolbox for simplicial complexes

simpcomp is an extension (a so called package) to GAP, the well known system for computational discrete algebra. The package enables the user to compute numerous properties of (abstract) simplicial complexes, provides functions to construct new complexes from existing ones and an extensive library of triangulations of manifolds.Comment: 4 page