17 research outputs found
Atomic Force Microscopy Study of the Effect of Pulsed Electric Field on Staphylococcus epidermidis
Effect of Low-Intensity Pulsed Electric Fields on the Respiratory Activity and Electrosurface Properties of Bacteria
Climate and Mobility in the West African Sahel: Conceptualising the Local Dimensions of the Environment and Migration Nexus
Irreversible Electroporation for Microbial Control of Drugs in Solution
The purpose of this study was to examine the feasibility of using irreversible electroporation (IRE) as a non-chemical method for eliminating microorganisms of liquid drugs. The studied drug was a topical ophthalmic medication, a pharmaceutical field in which the problem of microbial contamination has not yet been adequately solved, especially in the case of eye drops prescribed for chronic use. Commercially available Hylo-Comod® preservative-free eye drop solution was subjected to contamination with Escherichia coli bacteria (106 colony forming units/mL). Electroporation parameters for bacterial control were investigated by comparing the effects of electrical fields of 5.4, 7.2, and 10 kV/cm, delivered as 100-µs square pulses at 1 Hz in sequences of 10 pulses, 20 pulses, or 20 pulses delivered as four sets of five pulses with 1-min intervals between each set. Microorganism survival after treatment was determined by pour plate counting. Effects of the treatment parameters on temperature and pH were recorded. Bacterial survival was lowest (0.14% ± 0.03%) after application of 20 pulses delivered as four separate sets. With that application mode, the solution remained at pH 7.5 and the temperature rose to 35.6° ± 0.2°C. Because IRE can be efficiently delivered under conditions that avoid the potentially deleterious effects of electrical pulses on temperature and pH, it appears to be a feasible method for bacterial control of drugs in solution. The principles established in this study can be applied to any drug in solution and optimized individually according to the solution's composition
State Making and the Politics of the Frontier
International audienceKopytoff's model of the African frontier has opened room for renewed approaches to settlement history, politics, ethnicity and cultural reproduction in pre-colonial Africa. This interpretative framework applies well to central Benin (Ouessè). Over the long term, mobility has been a structural feature of the regional social history, from pre-colonial times onwards. Movements of people, resources, norms and values have been crucial in the production and reproduction of the social and political order. The colonial intrusion and its post-colonial avatars gave way to renewed relations between mobility and locality, in particular in the form of a complex articulation between control over labour force, access to land and natural resources, and out- and in-migrations. This article argues that the political frontier metaphor provides a useful heuristic device to capture the logic of state making, as the changing outcome of organizing practices taking place inside and outside state and non-state organizations and arenas. Governmentality in post-colonial central Benin thus results from the complex interplay of mobility, control over resources and state-led forms of 'villagization'
Tissue heterogeneity in structure and conductivity contribute to cell survival during irreversible electroporation ablation by “electric field sinks”
Geo-Located Tweets. Enhancing Mobility Maps and Capturing Cross-Border Movement
Capturing human movement patterns across political borders is difficult and this difficulty highlights the need to investigate alternative data streams. With the advent of smart phones and the ability to attach accurate coordinates to Twitter messages, users leave a geographic digital footprint of their movement when posting tweets. In this study we analyzed 10 months of geo-located tweets for Kenya and were able to capture movement of people at different temporal (daily to periodic) and spatial (local, national to international) scales. We were also able to capture both long and short distances travelled, highlighting regional connections and cross-border movement between Kenya and the surrounding countries. The findings from this study has broad implications for studying movement patterns and mapping inter/intra-region movement dynamics