Managing Distributed Information Systems Resources in a Globalized Environment

Research on international information systems suggests that alignment between IS service structures and the organizational structure is an important but complex issue. Little empirical work has been done, however, to identify how such alignment might be achieved. This paper reports on the results of a study examining the organizational factors which might be expected to have an impact on the alignment of IS resources in MNCs. Based on previous international research, nineteen factors are proposed and discussed through eight perspectives: organizational context, system owner, system goal, data, people, organizational structure, computer system and organizational environment. Finally, the results and findings of a questionnaire surveyand case studies regarding the structural alignment issues oflS in MNCs are presented. These show that only three of these factors have a strong influence on structural alignment and relate to the internal consistency of the organization rather than the external environment. Anumberofsecondaryfactorsarealsoidentifiedthroughthecaseanalyses. Theauthorssuggestthatmanyofthe proposed factors are based on out-dated principles and further suggest that the challenges of globalization are not fully understood by either practitioners or researchers

Olfactory variation in mouse husbandry and its implications for refinement and standardisation: UK survey of non-animal scents

With their highly sensitive olfactory system, the behaviour and physiology of mice are not only influenced by the scents of conspecifics and other species, but also by many other chemicals in the environment. The constraints of laboratory housing limit a mouse’s capacity to avoid aversive odours that could be present in the environment. Potentially odorous items routinely used for husbandry procedures, such as sanitizing products and gloves, could be perceived by mice as aversive or attractive, and affect their behaviour, physiology and experimental results. A survey was sent to research institutions in the UK to enquire about husbandry practices that could impact on the olfactory environment of the mouse. Responses were obtained from 80 individuals working in 51 institutions. Husbandry practices varied considerably. Seventy percent of respondents reported always wearing gloves for handling mice, with nitrile being the most common glove material (94%) followed by latex (23%) and vinyl (14%). Over six different products were listed for cleaning surfaces, floors, anaesthesia and euthanasia chambers and behavioural apparatus. In all cases Trigene™ (now called Anistel™) was the most common cleaning product used (43, 41, 40 and 49%, respectively). Depending on the attribute considered, between 7 and 19% of respondents thought that cleaning products definitely, or were likely to, have strong effects on standardization, mouse health, physiology or behaviour. Understanding whether and how these odours affect mouse welfare will help to refine mouse husbandry and experimental procedures through practical recommendations, to improve the quality of life of laboratory animals and the experimental data obtained

A Radio Polarimetric Study of the Galactic Center Threads

Multi-frequency, polarimetric VLA observations of the non-thermal filaments (NTF's), G0.08+0.15, and G359.96+0.09, also known as the Northern and Southern Threads are presented at 20, 6, 3.6 and 2 cm, with high enough spatial resolution to be resolved for the first time at 6 and 3.6 cm. The 20 cm image reveals a wealth of new detail in the radio sources lying within the inner 60 pc of the Galaxy. The Southern Thread has a prominent split along its length, similar to splitting at the ends of previously studied NTF's. With resolutions as fine as 2'', the 3.6 and 6 cm images reveal a high degree of continuity and little substructure internal to the filament. The spectral index of the Northern Thread has been determined over a broad range of frequencies. Its flux density falls with frequency, alpha=-0.5 between 90 and 6 cm, and becomes much steeper (alpha=-2.0) between 6 and 2 cm. The spectral index does not vary significantly along the length of the Northern Thread, which implies either that the diffusion timescale for the emitting electrons is less than their synchrotron lifetime, or that the emitting electrons are reaccelerated continuously at multiple positions along the filament. Because of the lack of spectral index variation, we have not located the source of relativistic electrons. Polarization observations at 6 and 3.6 cm confirm the non-thermal nature of the emission from the Northern Thread. The fractional polarization in the Northern Thread reaches 70% in some regions, although the polarized emission is patchy. Large rotation measures (RM > 2000 rad/m2) have been observed with irregular variations across the filament.The intrinsic magnetic field in the Northern Thread is predominantly aligned along its long axis.Comment: 19 pages, incl. 24 figs; to appear in the Astrophysical Journa

How do I sound to me? Perceived changes in communication in Parkinson's disease

Objective: To examine self and carer perceived changes in communication associated with Parkinson's disease and relate these to speech intelligibility, gender, age and other disease measures. Design: Cross-sectional survey of a hospital- and community-based sample of 176 people with Parkinson's disease and their carers using a questionnaire based on semantic differential techniques. Participants: One hundred and four people with Parkinson's disease with no history of communication difficulties prior to onset of their Parkinson's disease and 45 primary carers who returned completed questionnaires. Main outcome measures: Differences in ratings for `before' the onset of Parkinson's disease versus present status. Results: There was a strong perception of negative impact on communication between `before' and `now', irrespective of age and gender and largely independent of disease severity and duration, intelligibility and cognitive status. Activities of daily living (assessed by Unified Parkinson's Disease Rating Scale (UPDRS) II) and depression rating scale scores had the strongest association with change (adjusted R 2 0.27). There was a significant correlation between the rank order of perceived change in features examined in people with Parkinson's disease versus their carers, though in general carers rated change as having less impact. Conclusions: Parkinson's disease exercises a strong influence on communication even before apparent alterations to intelligibility or motor status

The Relationship between the UniProt Knowledgebase (UniProtKB) and the IntAct Molecular Interaction Databases

IntAct provides a freely available, open source database system and analysis tools for protein interaction data. All interactions are derived from literature curation or direct user submission and all experimental information relating to binary protein-protein
interactions is entered into the IntAct database by curators, via a web-based editor. Interaction information is added to the SUBUNIT comment and the RP line of the relevant publication within the UniProtKB entry. There may be a single INTERACTION comment present within a UniProtKB entry, which conveys information relevant to binary protein-protein interactions. This is automatically derived from the IntAct database and is updated on a triweekly basis. Interactions can be derived by any appropriate experimental method but must be confirmed by a second interaction if resulting from a single yeast2hybrid experiment. For large-scale experiments, interactions are considered if a high confidence score is assigned by the authors. The INTERACTION line contains a direct link to IntAct that provides detailed information for the experimental support. These lines are not changed manually and any discrepancy is reported to IntAct for updates. There is also a database crossreference line within the UniProtKB entry i.e.: DR IntAct _UniProtKB AC, which directs the user to additional interaction data for that molecule. 
UniProt is supported by grants from the National Institutes of Health, European Commission, Swiss Federal Government and PATRIC BRC.
IntAct is funded by the European Commission under FELICS, contract number 021902 (RII3) within the Research Infrastructure Action of the FP6 "Structuring the European Research Area" Programme

Changes in Physical Activity Behaviour and Health Risk Factors Following a Randomised Controlled Pilot Workplace Exercise Intervention

Background: Declining physical activity (PA) and associated health risk factors are well established. Workplace strategies to increase PA may be beneficial to ameliorate extensive sedentary behavior. This study assessed the effectiveness of two PA interventions in workplace settings. Methods: Interventions were conducted over 40 days targeting insufficiently active (<150 min/wk PA) and/or obese (BMI ≥ 30 kg/m2) adults; participants were randomly allocated to instructor-led exercise sessions either after-work (n = 25) or in-work (n = 23) with a 60 minPA/day common goal, or a wait-listed control group (n = 23). The programme commenced with low-moderate physical activities and progressed to high intensity game style activities by week six. Adherence and compliance were determined using both objective measures of daily PA time from HR monitors and self-report responses to PA questionnaires. Cardiovascular and metabolic risk factors were measured pre- and post-intervention. Changes across the study were analysed using Chi square and repeat-measures ANOVA. Results: Adherence rates (completed pre and post-testing) were not different between groups (76.0 vs 65.2%). Compliance for the instructor-led sessions was higher for the after-work group (70.4% vs 26.4%, respectively). Increased total PA and aerobic fitness, and decreased weight in both intervention groups were found relative to controls. The after-work group undertook more vigorous PA, and had greater weight loss and fasting blood glucose improvement, relative to in-work participants and controls. Conclusions: These workplace interventions resulted in rapid and dramatic increases in PA behaviour and important health benefits. Short, in-work PA sessions were less efficacious than longer after-work sessions