Study of pressure effect on the magnetic penetration depth in MgB2_2

A study of the pressure effect on the magnetic penetration depth $\lambda$ in polycrystalline MgB$_{2}$ was performed by measuring the temperature dependence of the magnetization under an applied pressure of 0.15 and 1.13 GPa. We found that $\lambda^{-2}$ at low temperature is only slightly affected by pressure [$\frac{\Delta \lambda^{-2}}{\lambda^{-2}} = 1.5(9)$], in contrast to cuprate superconductors, where, in the same range of pressure, a very large effect on $\lambda^{-2}$ was found. Theoretical estimates indicate that most of the pressure effect on $\lambda^{-2}$ in MgB$_2$ arises from the electron-phonon interaction.Comment: 5 pages, 2 figure

Pressure induced softening of YB_6: pressure effect on the Ginzburg-Landau parameter \kappa=\lambda/\xi

Measurements of the transition temperature T_c, the second critical filed H_{c2} and the magnetic penetration depth \lambda under hydrostatic pressure (up to 9.2 kbar) in the YB_6 superconductor were carried out. A pronounced and {\it negative} pressure effects (PE) on T_c and H_{c2} with dT_c/dp=-0.0547(4) K/kbar and \mu_0dH_{c2}(0)/dp =-4.84(20) mT/kbar, and zero PE on \lambda(0) were observed. The PE on the coherence length d\xi(0)/dp=0.28(2) nm/kbar was calculated from the measured pressure dependence of H_{c2}(0). Together with the zero PE on the magnetic penetration depth \lambda(0), our results imply that the Ginzburg-Landau parameter \kappa(0)=\xi(0)/\lambda(0) depends on pressure and that pressure "softens" YB_6, e.g. moves it to the type-I direction.Comment: 4 pages, 2 figure

Finite-size and pressure effects in YBa_2Cu_4O_8 probed by magnetic field penetration depth measurements

We explore the combined pressure and finite-size effects on the in-plane penetration depth \lambda_{ab} in YBa_2Cu_4O_8. Even though this cuprate is stoichiometric the finite-size scaling analysis of \lambda_{ab}^{-2}(T) uncovers the granular nature and reveals domains with nanoscale size L_{c} along the c-axis. L_{c} ranges from 33.2 Angstrom to 28.9 Angstrom at pressures from 0.5 to 11.5 kbar. These observations raise serious doubts on the existence of a phase coherent macroscopic superconducting state in cuprate superconductors.Comment: 7 pages, 6 figure

Pressure effects on the transition temperature and the magnetic field penetration depth in the pyrochlore superconductor RbOs_2O_6

We report magnetization measurements under high hydrostatic pressure in the newly discovered pyrochlore superconductor RbOs_2O_6 (T_c\simeq6.3K at p=0). A pronounced and {\it positive} pressure effect (PE) on T_c with dT_c/dp =0.090(1)K/kbar was observed, whereas no PE on the magnetic penetration depth \lambda was detected. The relative pressure shift of T_c [ dlnT_c/dp \simeq 1.5%/kbar] is comparable with the highest values obtained for highly underdoped high-temperature cuprate superconductors. Our results suggest that RbOs_2O_6 is an adiabatic BCS-type superconductor.Comment: 11 pages, 4 figure

Synthesis and structure-activity relationship studies of C(13)-desmethylene-(−)-zampanolide analogs

14 p.-4 fig.-2 tab.We describe the synthesis and biochemical and cellular profiling of five partially reduced or demethylated analogs of the marine macrolide (−)-zampanolide (ZMP). These analogs were derived from 13-desmethylene-(−)-zampanolide (DM-ZMP), which is an equally potent cancer cell growth inhibitor as ZMP. Key steps in the synthesis of all compounds were the formation of the dioxabicyclo[15.3.1]heneicosane core by an intramolecular HWE reaction (67–95 % yield) and a stereoselective aza-aldol reaction with an (S)-BINOL-derived sorbamide transfer complex, to establish the C(20) stereocenter (24–71 % yield). As the sole exception, for the 5-desmethyl macrocycle, ring-closure relied on macrolactonization; however, elaboration of the macrocyclization product into the corresponding zampanolide analog was unsuccessful. All modifications led to reduced cellular activity and lowered microtubule-binding affinity compared to DM-ZMP, albeit to a different extent. For compounds incorporating the reactive enone moiety of ZMP, IC50 values for cancer cell growth inhibition varied between 5 and 133 nM, compared to 1–12 nM for DM-ZMP. Reduction of the enone double bond led to a several hundred-fold loss in growth inhibition. The cellular potency of 2,3-dihydro-13-desmethylene zampanolide, as the most potent analog identified, remained within a ninefold range of that of DM-ZMP.This workwas supported by the Swiss National Science Foundation (KHA,project200021_149253). Institutional support by the ETH Zurich is also gratefully acknowledged(KHA).Funding was also received from Ministerio de Ciencia e Innovación(Spain) (JFD,Project PID2019-104545RB-I00/AEI/10.13039/501100011033),the European Commission-NextGenerations EU(RegulationEU 2020/2094),through CSIC’s Global Health Platform(PTI Salud Global) and Proyecto de Investigación en Neurociencia Fundación Tatiana Pérez de Guzmán el Bueno 2020 (JFD).Peer reviewe

Influence of virtual reality soccer game on walking performance in robotic assisted gait training for children

BACKGROUND: Virtual reality (VR) offers powerful therapy options within a functional, purposeful and motivating context. Several studies have shown that patients' motivation plays a crucial role in determining therapy outcome. However, few studies have demonstrated the potential of VR in pediatric rehabilitation. Therefore, we developed a VR-based soccer scenario, which provided interactive elements to engage patients during robotic assisted treadmill training (RAGT). The aim of this study was to compare the immediate effect of different supportive conditions (VR versus non-VR conditions) on motor output in patients and healthy control children during training with the driven gait orthosis Lokomat*. METHODS: A total of 18 children (ten patients with different neurological gait disorders, eight healthy controls) took part in this study. They were instructed to walk on the Lokomat in four different, randomly-presented conditions: (1) walk normally without supporting assistance, (2) with therapists' instructions to promote active participation, (3) with VR as a motivating tool to walk actively and (4) with the VR tool combined with therapists' instructions. The Lokomat gait orthosis is equipped with sensors at hip and knee joint to measure man-machine interaction forces. Additionally, subjects' acceptance of the RAGT with VR was assessed using a questionnaire. RESULTS: The mixed ANOVA revealed significant main effects for the factor CONDITIONS (p < 0.001) and a significant interaction CONDITIONS x GROUP (p = 0.01). Tests of between-subjects effects showed no significant main effect for the GROUP (p = 0.592). Active participation in patients and control children increased significantly when supported and motivated either by therapists' instructions or by a VR scenario compared with the baseline measurement "normal walking" (p < 0.001). CONCLUSIONS: The VR scenario used here induces an immediate effect on motor output to a similar degree as the effect resulting from verbal instructions by the therapists. Further research needs to focus on the implementation of interactive design elements, which keep motivation high across and beyond RAGT sessions, especially in pediatric rehabilitation

Co-founding ant queens prevent disease by performing prophylactic undertaking behaviour

Abstract Background Social insects form densely crowded societies in environments with high pathogen loads, but have evolved collective defences that mitigate the impact of disease. However, colony-founding queens lack this protection and suffer high rates of mortality. The impact of pathogens may be exacerbated in species where queens found colonies together, as healthy individuals may contract pathogens from infectious co-founders. Therefore, we tested whether ant queens avoid founding colonies with pathogen-exposed conspecifics and how they might limit disease transmission from infectious individuals. Results Using Lasius niger queens and a naturally infecting fungal pathogen Metarhizium brunneum, we observed that queens were equally likely to found colonies with another pathogen-exposed or sham-treated queen. However, when one queen died, the surviving individual performed biting, burial and removal of the corpse. These undertaking behaviours were performed prophylactically, i.e. targeted equally towards non-infected and infected corpses, as well as carried out before infected corpses became infectious. Biting and burial reduced the risk of the queens contracting and dying from disease from an infectious corpse of a dead co-foundress. Conclusions We show that co-founding ant queens express undertaking behaviours that, in mature colonies, are performed exclusively by workers. Such infection avoidance behaviours act before the queens can contract the disease and will therefore improve the overall chance of colony founding success in ant queens

Introduction: exploring and explaining the Asia-Pacific Partnership on Clean Development and Climate

This introduction lays the groundwork for this Special Issue by providing an overview of the Asia-Pacific Partnership on Clean Development and Climate (APP), and by introducing three main analytical themes. The first theme concerns the emergence and continuation of the APP. The contributions show that the emergence of the APP can be attributed to international factors, including the United States' rejection of the Kyoto Protocol, and its search for an alternative arena for global climate governance, and other countries' wish to maintain good relations with the US; as well as domestic factors, such as the presence of bureaucratic actors in favour of the Partnership, alignment with domestic priorities, and the potential for reaping economic benefits through participation. The second theme examines the nature of the Partnership, concluding that it falls on the very soft side of the hard-soft law continuum and that while being branded as a public-private partnership, governments remain in charge. Under the third theme, the influence which the APP exerts on the post-2012 United Nations (UN) climate change negotiations is scrutinised. The contributions show that at the very least, the APP is exerting some cognitive influence on the UN discussions through its promotion of a sectoral approach. The introduction concludes with outlining areas for future research. © Springer Science+Business Media B.V. 2009

A high-resolution air chemistry record from an Alpine ice core: Fiescherhorn glacier, Swiss Alps

Glaciochemical studies at midlatitudes promise to contribute significantly to the understanding of the atmospheric cycling of species with short atmospheric lifetimes. Here we present results of chemical analyses of environmentally relevant species performed on an ice core from Fiescherhorn glacier, Swiss Alps (3890 m above sea level). This glacier site is unique since it is located near the high-alpine research station Jungfraujoch. There long-term meteorological and air quality measurements exist, which were used to calibrate the paleodata. The 77-m-long ice core was dated by annual layer counting using the seasonally varying signals of tritium and δ18O. It covers the time period 1946–1988 and shows a high net accumulation of water of 1.4 m yr−1 allowing for the reconstruction of high-resolution environmental records. Chemical composition was dominated by secondary aerosol constituents as well as mineral dust components, characterizing the Fiescherhorn site as a relatively unpolluted continental site. Concentrations of species like ammonium, nitrate, and sulfate showed an increasing trend from 1946 until about 1975, reflecting anthropogenic emission trends in western Europe. For mineral dust tracers, no trends were obvious, whereas chloride and sodium showed slightly higher levels from 1965 until 1988, indicating a change in the strength of sea-salt transport. Good agreement between the sulfate paleorecord with direct atmospheric measurements was found (correlation coefficient r2 = 0.41). Thus a “calibration” of the paleorecord over a significant period of time could be conducted, revealing an average scavenging ratio of 180 for sulfate