Platelet-Rich Plasma in Trauma Patients

Platelet-rich plasma (PRP) was mixed with thrombin and excess calcium resulting in activated platelets trapped within the fibrin network; within the matrix, platelets secrete bioactive substances that diffuse into the surroundings tissues. PRP is prepared from the patient’s own blood, a variety of manufacturing techniques in vastly different cell counts, and growth factor concentrations. The clinical use of PRP is treatment of soft tissue diseases and injuries, treatment of burns, hard-to-heal wounds, tissue engineering, and implantology in dentistry. An essential criterion for PRP is for it to be autologous, for the donor of the blood, and the recipient of the PRP to the same person. Most of the literatures suggest that PRP does not appreciably impact bone healing or induce bone formation. PRP might augment recruitment of osteoblast progenitors to injection sites or in sites expected to experience delayed healing. In this capacity, PRP might be utilized to initiate repair of an otherwise poorly healing bony lesion. PRP stimulates bone repair in fractures. Early through late healing process is compromised with fractures, including reduced cell proliferation, delayed chondrogenesis, and decreased biomechanical properties. In this chapter, the importance of the PRP in oral and maxillofacial surgery in trauma patients is studie

Biomaterial Used in Trauma Patients

The development of bone tissue engineering and bone regeneration is always of interest to improve methods to reduce costs of trauma patient. Ability to use autogenous bone forming cells attached to bone morphogenetic proteins would be ideal. There are many clinical reasons to develop bone tissue engineering alternatives, for use in the reconstruction of large defects and implants. The traditional methods of bone defect management include autografting and allografting cancellous bone, vascularized grafts, and other bone transport techniques. However, these are the standard treatments. Since bone grafts are avascular and dependent on the size of the defect, the viability can limit their application. In large defects, the grafts can be resorbed by the body before osteogenesis is complete; tissue loss develops in the living organism due to infection, trauma, congenital, and physiological reasons. Placing tissue defects in the dentist and maxillofacial surgery and accelerating wound healing are an important issue. From an old Egypt, material used in treatment of different doctors with various causes. Oral surgery, periodontology, and implantology, which are surgical branches of the dentistry, need to increase bone formation in the treatment of bone defects, congenital defects, and defects around the implant. Many years of work have been done to obtain ideal biomaterials, and many materials have been used. We have prepared detailed information on biomaterials used in dentistry, oral, and maxillofacial surgeries in this book to help dentists and dental students

MANDİBULADA MULTİPL MYELOMA İKİ OLGU SUNUMU

Multipl myeloma MM , erişkin çağın en sıkgörülen kemik tümörlerindendir. MM genellikle,kafatası, klavikula, vertebra, pelvis gibi yassıkemikleri tutar. Bu makalede mandibula posterior bölgeyitutan iki MM olgusu sunulmaktadır. İlk olgumuz57 yaşında alt çene sol tarafta ağrılı yumuşak dokukitlesi ile başvuran erkek hasta idi. İkinci olgumuzise 46 yaşında herhangi bir klinik şikayeti olmaks›z›n başvuran erkek hastayd›. Histopatolojik değerlendirmelerinde, plazma hücre infiltrasyonu ve immunohistokimyasal olarak kappa hafif zincir monoklonalitesi gözlenmiştir. MM 'da oral bulgular›n ortaya ç›kmas›, hastan›n ileri dönemde olduğuna işaret eder. Bu nedenle multipl myelomada olgular›n›n dikkatli değerlendirilmesi ve multidisipliner yaklaş›m gereklidi