11 research outputs found
Os flavonóides da uva melhoram o perfil antioxidante na insuficiência cardíaca direita em ratos
27
Os flavonóides da uva melhoram o perfil antioxidante na insuficiência cardíaca direita em ratos
27
Avaliação do crescimento em ratos com insuficiência cardíaca direita tratados com flavonóides
03
Efeitos do suco de uva e vinho tinto na insuficiência cardíaca direita : aspectos hemodinâmicos
41
Developmental dynamics of the neural crest-mesenchymal axis in creating the thymic microenvironment
The thymic stroma is composed of epithelial and nonepithelial cells providing separate microenvironments controlling homing, differentiation, and selection of hematopoietic precursor cells to functional T cells. Here, we explore at single-cell resolution the complex composition and dynamic changes of the nonepithelial stromal compartment across different developmental stages in the human and mouse thymus, and in an experimental model of the DiGeorge syndrome, the most common form of human thymic hypoplasia. The detected gene expression signatures identify previously unknown stromal subtypes and relate their individual molecular profiles to separate differentiation trajectories and functions, revealing an unprecedented heterogeneity of different cell types that emerge at discrete developmental stages and vary in their expression of key regulatory signaling circuits and extracellular matrix components. Together, these findings highlight the dynamic complexity of the nonepithelial thymus stroma and link this to separate instructive roles essential for normal thymus organogenesis and tissue maintenance.ISSN:2375-254
Efeitos dos flavonóides da uva preta na insuficiência cardíaca direita : avaliação do estresse oxidativo
03
Efeitos dos flavonóides da uva preta na insuficiência cardíaca direita : aspectos hemodinâmicos
38