The Shaker Potassium Channel Is No Target for Xenon Anesthesia in Short-Sleeping Drosophila melanogaster Mutants

Background. Xenon seems to be an ideal anesthetic drug. To explore if next to the antagonism at the NMDA-receptor other molecular targets are involved, we tested the xenon requirement in short sleeping Drosophila shaker mutants and in na[har38]. Methods. The Drosophila melanogaster strains wildtype Canton-S, na[har38], sh102 and shmns, were raised and sleep was measured. Based on the response of the flies at different xenon concentrations, logEC50 values were calculated. Results. The logEC50-values for WT Canton-S were 1.671 (1.601–1.742 95%-confidence intervall; n = 238; P versus sh102 > 0,05), for shmns 1.711 (1.650–1.773; n = 242; P versus WT Canton-S > 0,05). The logEC50-value for sh102 was 1.594 (1.493–1.694; n = 261; P versus shmns > 0.05). The logEC-value of na[har38] was 2.076 (1.619–2.532; n = 207; P versus shmns < 0.05, versus sh102 < 0.05, versus WT Canton-S < 0.05). P values for all shaker mutants were P > 0.05, while na[har38] was found to be hyposensitive compared to wildtype (P < 0.05). Conclusions. The xenon requirement in Drosophila melanogaster is not influenced by a single gene mutation at the shaker locus, whereas a reduced expression of a nonselective cation channel leads to an increased xenon requirement. This supports the thesis that xenon mediates its effects not only via an antagonism at the NMDA-receptor

Система автоматического регулирования температуры теплоносителя теплосети котельной №4 ООО «Газпром Трансгаз Томск»

Выпускная квалификационная работа содержит 112 с., рис.12, табл.29, 19 источников, прил.6. Объектом исследования является система теплоснабжения комплекса зданий Управления АиСТ ООО ?Газпром Трансгаз Томск? в г. Томске. Цель работы – разработка САР температуры теплоносителя теплосети для системы теплоснабжения. В процессе выполнения работы проводился анализ объекта регулирования, разработка функциональной, структурной, и принципиальной электрической схемы САР температуры теплоносителя, расчет оптимальных параметров настройки регулятора, выбор технических средств автоматизации для данного объекта. В ходе проведенных исследований произведена разработка системы автоматического регулирования температуры теплоносителя на базе современных технических средств автоматизации.Final qualifying work contains 112 pages., pictures12, 29 tables, 19 sources, applications 6. The object of research is the system of heat supply of the complex motor and special transport management of buildings LLC "Gazprom Transgaz Tomsk" in Tomsk. Objective - Development of automatic control system coolant temperature heating system for the heating system. In carrying out the work, an analysis of the object of regulation, the development of functional, structural, and electrical schematic diagram of the system of automatic control of the flow temperature, the calculation of the optimal controller settings, the choice of means of automation of the object

Разработка технологического процесса изготовления боковой плиты

Целью данной выпускной квалификационной работы была: Разработка технологии изготовления боковой плиты. Работа состоит из четырех частей: Технологическая, Конструкторская, Экономическая. Социальная ответсвенность проекта. В первой части было сделано заключение о технологичности детали, по заданной годовой программе выпуска определен тип производства, разработан маршрут обработки, по которому произведен размерный анализ, из которого видно, какие конструкторские размеры выдерживаются непосредственно, а какие нет, для котороых в дальнейшем проведена проверка обеспечения точности этих размеров. Затем расчитаны технологические размеры, после назначения на них допусков и расчета минимальных припусков на обработку, назначен режущий и мерительный инструмент. Далее для всех переходов рассчитаны реPurpose of this final qualification work: Development of manufacturing techniques of a side plate. Work consists of four parts: Technological, Design, Economic. Social responsibility of the project. In the first part the conclusion about technological effectiveness of a detail has been made, the production type is determined by the set annual program of release, the handling route along which the dimensional analysis from which it is visible is made what design sizes are maintained directly and what are not present is developed, for the kotoroykh ensuring accuracy of these sizes is performed further. Then the technological sizes, after purpose on them of admissions and calculation of the minimum allowances for handling are calculated, the cutting and measuring tool is appointed. Further f

Constraint on the CKM angle alpha from the experimental measurements of CP violation in B_d^0 --> pi^+ pi^- decay

In this paper, we study and try to find the constraint on the CKM angle alpha from the experimental measurements of CP violation in B_d^0 --> pi^+ pi^- decay, as reported very recently by BaBar and Belle Collaborations. After considering uncertainties of the data and the ratio r of penguin over tree amplitude, we found that strong constraint on both the CKM angle alpha and the strong phase delta can be obtained from the measured CP asymmetries S_{pi pi} and A_{pi pi}: (a) the ranges of 87 degrees <= alpha <= 131 degrees and 36 degrees <= delta <= 144 degrees are allowed by 1 sigma of the averaged data for r = 0.31; (b) for Belle's result alone, the limits on alpha and delta are 104 degrees <= alpha <= 139 degrees and 42 degrees <= delta <= 138 degrees for 0.32 <= r <= 0.41; and (c) the angle alpha larger than 90 degrees is preferred.Comment: Revtex, 17 pages with 6 ps/eps figure files, new Babar data Reported at ICHEP 2002 considere

Проект установки каталитического превращения синтез-газа в метанол

В данном дипломном проекте разработана установка каталитического превращения синтез-газа в метанол. При выполнении данной работы основываюсь на производство метанола из природного газа. Мощность проектируемой установки 815000 т/год, с выходом основного вещества 99,95 % в метаноле-ректификате. Изложены теоретические основы получения метанола. Приведены расчеты материального и теплового балансов. Выполнены механические и технологические расчеты, разработана схема контрольно-измерительных приборов и автоматизации. Разработан разделы: «Финансовый менеджмент, ресурсоэффективность и ресурсосбережение» и «Социальная ответственность».The methanol synthesis reactor, catalyst, synthesis gas, column, plate, raw methanol, temperature, pressure. In this thesis project developed a catalytic conversion of synthesis gas to methanol. When performing this work are based on the production of methanol from natural gas. The projected capacity of the installation 815000 tons/year, with the release of the basic substance 99.95 % of the methanol-rectified. The theoretical basis for the production of methanol. The calculations of material and heat balance. Performed mechanical and process calculations, developed a scheme of instrumentation and automation. Developed sections: Financial management, resource efficiency and resource conservation" and "Social responsibility"

Strong and Weak Phases from Time-Dependent Measurements of B→ππB \to \pi \pi

Time-dependence in $B^0(t) \to \pi^+ \pi^-$ and \ob(t) \to \pi^+ \pi^- is utilized to obtain a maximal set of information on strong and weak phases. One can thereby check theoretical predictions of a small strong phase $\delta$ between penguin and tree amplitudes. A discrete ambiguity between $\delta \simeq 0$ and $\delta \simeq \pi$ may be resolved by comparing the observed charge-averaged branching ratio predicted for the tree amplitude alone, using measurements of $B \to \pi l \nu$ and factorization, or by direct comparison of parameters of the Cabibbo-Kobayashi-Maskawa (CKM) matrix with those determined by other means. It is found that with 150 fb$^{-1}$ from BaBar and Belle, this ambiguity will be resolvable if no direct CP violation is found. In the presence of direct CP violation, the discrete ambiguity between $\delta$ and $\pi - \delta$ becomes less important, vanishing altogether as $|\delta| \to \pi/2$. The role of measurements involving the lifetime difference between neutral $B$ eigenstates is mentioned briefly.Comment: 14 pages, LaTeX, 5 figures, to be published in Phys. Rev. D. Updated version with one reference change

Charmless two-body B decays: A global analysis with QCD factorization

In this paper, we perform a global analysis of $B \to PP$ and $PV$ decays with the QCD factorization approach. It is encouraging to observe that the predictions of QCD factorization are in good agreement with experiment. The best fit $\gamma$ is around $79^\circ$. The penguin-to-tree ratio $|P_{\pi \pi}/T_{\pi \pi}|$ of $\pi^+ \pi^-$ decays is preferred to be larger than 0.3. We also show the confidence levels for some interesting channels: $B^0 \to \pi^0 \pi^0$, $K^+ K^-$ and $B^+ \to \omega \pi^+$, $\omega K^+$. For $B \to \pi K^\ast$ decays, they are expected to have smaller branching ratios with more precise measurements.Comment: 20 pages, 4 figures, version to appear in Phys. Rev.

Солнечно-дизельная система электроснабжения автономного потребителя

В работе проводится выбор оборудования солнечно-дизельной электростанции автономного потребителя. В процессе расчета построены графики нагрузки автономного потребителя за четыре сезона, рассчитаны оптимальные углы наклона солнечных панелей и определены количество солнечных батарей, рассчитано число накопителей, необходимых для запаса излишней энергии. Рассмотрен вариант энергетического комплекса с использованием солнечных панелей, накопителей электроэнергии и дизельной электрической установки. А также произведено исследование режимов работы энергетических комплексов.In the work, the equipment of the solar-diesel power plant of the autonomous consumer is selected. In the process of calculation, the graphs of the load of an autonomous consumer for four seasons are constructed, the optimum angles of the inclination of the solar panels are calculated and the number of solar batteries is calculated, the number of storage devices necessary for a surplus energy reserve is calculated. A variant of the power complex with the use of solar panels, power storage devices and a diesel electric installation is considered. And also the research of operating modes of power complexes is made

What can we learn from a measurement of sin(2 beta + gamma)?

The constraints on the value of the CKM phase gamma that may be achieved by prospective measurements of sin(2 beta) and sin(2 beta + gamma) are discussed. Significant constraints require quite small errors, and may depend on assumptions about strong phases. The measurement of sin(2 beta + gamma) combined with other experiments could provide valuable limits on new physics in Bd-Bdbar mixing.Comment: 10 pages, 7 figures, RevTex 4, uses amsmath and graphic