99 research outputs found
Polymer transport in random flow
The dynamics of polymers in a random smooth flow is investigated in the
framework of the Hookean dumbbell model. The analytical expression of the
time-dependent probability density function of polymer elongation is derived
explicitly for a Gaussian, rapidly changing flow. When polymers are in the
coiled state the pdf reaches a stationary state characterized by power-law
tails both for small and large arguments compared to the equilibrium length.
The characteristic relaxation time is computed as a function of the Weissenberg
number. In the stretched state the pdf is unstationary and exhibits
multiscaling. Numerical simulations for the two-dimensional Navier-Stokes flow
confirm the relevance of theoretical results obtained for the delta-correlated
model.Comment: 28 pages, 6 figure
Elastic turbulence in curvilinear flows of polymer solutions
Following our first report (A. Groisman and V. Steinberg, \sl Nature , 53 (2000)) we present an extended account of experimental observations of
elasticity induced turbulence in three different systems: a swirling flow
between two plates, a Couette-Taylor (CT) flow between two cylinders, and a
flow in a curvilinear channel (Dean flow). All three set-ups had high ratio of
width of the region available for flow to radius of curvature of the
streamlines. The experiments were carried out with dilute solutions of high
molecular weight polyacrylamide in concentrated sugar syrups. High polymer
relaxation time and solution viscosity ensured prevalence of non-linear elastic
effects over inertial non-linearity, and development of purely elastic
instabilities at low Reynolds number (Re) in all three flows. Above the elastic
instability threshold, flows in all three systems exhibit features of developed
turbulence. Those include: (i)randomly fluctuating fluid motion excited in a
broad range of spatial and temporal scales; (ii) significant increase in the
rates of momentum and mass transfer (compared to those expected for a steady
flow with a smooth velocity profile). Phenomenology, driving mechanisms, and
parameter dependence of the elastic turbulence are compared with those of the
conventional high Re hydrodynamic turbulence in Newtonian fluids.Comment: 23 pages, 26 figure
Initial results from beam commissioning of the LHC beam dump system
Initial commissioning of the LHC beam dump system with beam took place in August and September 2008. The preparation, setting-up and the tests performed are described together with results of the extractions of beam into the dump lines. Analysis of the first detailed aperture measurements of the extraction channels and kicker performance derived from dilution sweep shapes are presented. The performance of the other equipment subsystems is summarised, in particular that of the dedicated dump system beam instrumentation
Experimental evidence for multi-pass extraction with a bent crystal
The feasibility of extracting particles from the halo of a circulating proton beam using a bent silicon crystal has been demonstrated experimentally at the SPS for a beam energy of 120 GeV. Presently studies are conducted to understand the extraction mechanisms and the measured efficiencies. In particular the contribution of multi-pass extraction, where the particles can pass through the crystal many times before being channelled and extracted, is investigated. In a recent experiment, using a crystal especially fabricated with a finite amorphous layer on its surface, it has been proven that multi-pass extraction plays an important role. The experiment is described and the implication for further studies are discussed
Protein network analysis reveals selectively vulnerable regions and biological processes in FTD
Immune-related genetic enrichment in frontotemporal dementia: An analysis of genome-wide association studies
Shared genetic risk between corticobasal degeneration, progressive supranuclear palsy, and frontotemporal dementia
CXCR4 involvement in neurodegenerative diseases
Neurodegenerative diseases likely share common underlying pathobiology. Although prior work has identified susceptibility loci associated with various dementias, few, if any, studies have systematically evaluated shared genetic risk across several neurodegenerative diseases. Using genome-wide association data from large studies (total n = 82,337 cases and controls), we utilized a previously validated approach to identify genetic overlap and reveal common pathways between progressive supranuclear palsy (PSP), frontotemporal dementia (FTD), Parkinson's disease (PD) and Alzheimer's disease (AD). In addition to the MAPT H1 haplotype, we identified a variant near the chemokine receptor CXCR4 that was jointly associated with increased risk for PSP and PD. Using bioinformatics tools, we found strong physical interactions between CXCR4 and four microglia related genes, namely CXCL12, TLR2, RALB, and CCR5. Evaluating gene expression from post-mortem brain tissue, we found that expression of CXCR4 and microglial genes functionally related to CXCR4 was dysregulated across a number of neurodegenerative diseases. Furthermore, in a mouse model of tauopathy, expression of CXCR4 and functionally associated genes was significantly altered in regions of the mouse brain that accumulate neurofibrillary tangles most robustly. Beyond MAPT, we show dysregulation of CXCR4 expression in PSP, PD, and FTD brains, and mouse models of tau pathology. Our multi-modal findings suggest that abnormal signaling across a 'network' of microglial genes may contribute to neurodegeneration and may have potential implications for clinical trials targeting immune dysfunction in patients with neurodegenerative diseases.We thank the International FTD-GWAS Consortium (IFGC), International Parkinson’s Disease Genomic Consortium (IPDGC) and International Genomics of Alzheimer’s Project (IGAP) for providing summary statistics data for these analyses. Further acknowledgments for IFGC, IPDGC and IGAP are found in the Supplemental material. This research was supported by grants from the National Institutes of Health (NIH-AG046374 [CMK] and K01 AG049152 [JSY]), Larry J. Hillblom Foundation (2016-A-005-SUP [JSY]), Research Council of Norway (#213837, #225989, #223273, and #237250/EU JPND [OAA]), South East Norway Health Authority (2013-123), Norwegian Health Association, the Radiological Society of North America (RMS1741 [LWB]) (RSD), ASNR Foundation AD Imaging Award (RSD), National Alzheimer’s Coordinating Center (NACC) Junior Investigator (JI) Award (RSD), the Tau Consortium (JSY), and Alzheimer's Society grant 284 (RF)
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