37 research outputs found
INVESTIGATION OF THE PREPARATION OF 2,4,6-TRIARYL-PYRYLIUM FLUOROBORATES FROM AROMATIC ALDEHYDES AND ARYL METHYL KETONES. I. THIN LAYER CHROMATOGRAPHY TESTING OF THE REACTION
KINETIK DER ALKALISCHEN ZERSETZUNG DES PHENYL-3-D-GLUCOSIDTETRAACETATS UND SEINER PHENYLSUBSTITUIERTEN DERIVATE
Diagnosing Vitreoretinal LymphomasâAn Analysis of the Sensitivity of Existing Tools
Vitreoretinal Lymphoma (VRL) is a rare ocular pathology that is notorious for mimicking chronic uveitis, which is a seemingly benign condition in comparison. The most common form of VRL is the diffuse large B-cell type, and there has been a high mortality rate. This dismal prognosis can be improved significantly if the disease is diagnosed early, but until now there is no consensus on an appropriate diagnostic algorithm. We conducted a retrospective search of PubMed CentralÂź and analyzed results from thirty-three studies that were published between 2011â2021. The chosen studies incorporated some popular testing tools for VRL, and our analyses focused on comparing the average sensitivity of five diagnostic methods. The methods included cytology including ancillary immunohistochemistry, Myeloid Differentiation Factor 88 (MyD88) mutation analysis, polymerase chain reaction (PCR) for monoclonal rearrangements of immunoglobulin heavy chain (IgH) and T-cell Receptor (TCR) genes, flow cytometry, and IL10 and IL6 analysis. Across the varied diagnostic methods employed in thirty-three studies explored in this analysis, MyD88 mutation assay emerged as a strong contender given its sensitivity and low coefficient of variation. There is an imminent need for the introduction of newer assays that can further improve the sensitivity of identifying MyD88 mutation in cancer cells seen in the vitreous
Downstaging of hepatocellular carcinoma with radiofrequency ablation on the Hungarian liver transplantation waiting list: Early results and learned lessons
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