Cardiovascular risk associated with co-morbid insomnia and sleep apnoea (COMISA) in type 2 diabetics

Objective: In the general population, co-morbid insomnia and sleep apnoea (COMISA) is associated with higher risk of cardiovascular diseases (CVD). However, despite a high prevalence of COMISA in type 2 diabetics, no study has investigated its potential implication in the negative cardiovascular outcome of this particular subpopulation. The aim of this study was therefore to examine the risk of CVD associated with COMISA in type 2 diabetics. Methods: Data from 471 type 2 diabetics recruited from the clinical database of the Erasme Hospital sleep laboratory were analysed. Only type 2 diabetics with SCORE index ≥5% were included in the group at high risk of CVD. Logistic regression analyses were conducted to examine the risk of CVD associated with COMISA in type 2 diabetics. Results: A high risk of CVD was present in 32.9% of type 2 diabetics. After adjustment for the main confounding factors associated with cardiovascular risk, multivariate logistic regression analysis revealed that unlike obstructive sleep apnoea syndrome or insomnia alone, only COMISA was associated with higher risk of CVD in type 2 diabetics. Discussion: In our study, we have demonstrated that unlike its components alone, only COMISA was associated with higher risk of CVD in type 2 diabetics, which highlights the importance of the central role played by the negative synergistic effect of COMISA on the cardiovascular outcome in this particular subpopulation. Thus, given these elements, more systematic research and adequate therapeutic management of COMISA seem to be necessary to allow better cardiovascular prevention in type 2 diabetics

Les particularités du DSM-V

The aim of the present article is to present an overview of the recently published 5th version of the DSM. After a brief historic of the different versions of the DSM since the third edition, the main features of the classification were presented followed by the particularities of the fifth version.SCOPUS: re.jinfo:eu-repo/semantics/publishe

Anhedonia and risk of suicide: An overview

The studies of the relationship between anhedonia and risk of suicide have led to conflicting results. The aim of the present paper is to review the different studies and to propose a conceptual model of anhedonia allowing to understand the different role of anhedonia in the risk of suicide.SCOPUS: ch.binfo:eu-repo/semantics/publishe

Alexithymia and dependent personality disorder.

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Anhedonia in heart disease

Several recent studies have reported that anhedonia could constitute a particular cardiotoxic symptom in subjects with acute coronary syndrome (ACS) or other cardio-vascular diseases. The aim of this overview was to briefly present the recent studies and propose several guidelines taking the limitations of these studies into account. Several hypotheses concerning the relationships between anhedonia and ACS are proposed as well as the relevance of using more restricted and validated definition of hedonic deficits taking into account the distinction between consummatory and anticipatory pleasures.SCOPUS: ch.binfo:eu-repo/semantics/publishe

Les symptômes de base (place dans l'approche dimensionnelle de la schizophrénie et intérêt prédictif)

Nos travaux se sont centrés sur l exploration des expériences subjectives de la schizophrénie telles qu elles ont été décrites au milieu du siècle dernier par Huber sous l appellation symptômes de base . La première partie est consacrée aux travaux de traduction et de validation d outils évaluant d une part les symptômes de Base (Questionnaire des Plaintes de Francfort - QPF et Echelle des Expériences Subjectives de Déficit) et d autre part les dérapages cognitifs (Echelle de Dérapage Schizotypique) et l ambivalence schizotypique (Echelle d ambivalence Schizotypique). La seconde partie des travaux est clinique. Elle conclut au caractère unidimensionnel du QPF. Elle montre ensuite que les symptômes subjectifs constituent une dimension spécifique de la schizophrénie d une part différenciée des dimensions objectives évaluées par la P.A.N.S.S. et d autre part corrélée à la dimension schizotypique positive. Enfin, au vu de ces résultats, est discuté l intérêt de considérer les symptômes de base comme des endophénotypesPARIS-BIUSJ-Thèses (751052125) / SudocPARIS-BIUSJ-Physique recherche (751052113) / SudocSudocFranceF

Absolute and relative short-term stability of interpersonal dependency in suicide attempters.

Previous studies have reported an association between suicide and interpersonal dependency (IPD), but no study has examined whether IPD constitutes a state-dependent phenomenon or an enduring personality trait in this association. The aims of the present study were, firstly, to evaluate both the absolute and the relative stability of IPD as well as depression in suicide attempters and, secondly, to examine whether the relative stability of IPD was related to the depressive level rated on admission and/or at follow-up. The sample consisted of 41 suicide attempters evaluated on admission and 1 month later. The subjects filled in the Interpersonal Dependency Inventory (IDI) and the Beck Depression Inventory-II (BDI-II). The absolute and the relative stability of depression and IPD were analyzed using paired t-tests and Pearson's or intraclass correlation coefficients, respectively. The relative stability of IPD, taking into account the changes of the depressive level, was tested by two regression analyses. In the first regression analysis follow-up, the IDI scores were the dependent variable and the baseline IDI scores and BDI-II scores were the predictors. In the second regression analysis, the IDI change scores were the dependent variable and the BDI-II change scores were the predictors. Absolute and relative stability were demonstrated for IPD, whereas depression presented only relative stability. The IPD scores on admission were also significant predictors of the follow-up IPD scores after controlling for depression level. The 1-month duration of follow-up may be too brief to detect any decrease in the level of IPD. In conclusion, in contrast with the depression scores, the IPD scores presented short-term absolute and relative stability, and these results support the view that IPD is a stable personality trait in suicide attempters. The stability of IPD in suicide attempters suggests the interest of specific therapeutic approaches of this personality trait.Journal Articleinfo:eu-repo/semantics/publishe

L'anhédonie en psychiatrie: revue.

Anhedonia, the loss of the capacity of feeling pleasure, was first introduced at the end of the last century by a French psychologist, Ribot, and has been the object of much research, essentially in English, for the last decades, in schizophrenia, in depression, in schizoid disorders. After considering the problems of quantitative evaluation, we review the literature and conclude that anhedonia appears to be a multi-morphological symptom and the are probably several types of anhedonia, which shows the necessity of developing more specific reliable evaluation instruments and of diversifying the approaches. We show the utility, in particular, of a psychophysiological approach using endogenous Evoked Potentials. Then several research directions in psychiatry are discussed: what place has anhedonia in the negative form of schizophrenia? Does anhedonia constitute a specific marker of certain endogenous depressions? Does it constitute a personality trait that predisposes to morbidity?info:eu-repo/semantics/publishe

Relationship between type d personality and anhedonia: A dimensional study of university students

Type D personality—characterized by negative aff ectivity and social inhibition—and anhedonia have independently been found to be signifi cantly associated with depression or suicidal ideation in the general population or in psychiatric subjects. The aim of the study was to evaluate the association between Type D personality and anhedonia in a population of 204 university students (102 men, 102 women) after controlling for depression as a confounding variable. Type D personality was evaluated using the Type D scale, anhedonia with the Snaith-Hamilton Pleasure Scale, and depression with the Beck Depression Inventory–II. Signifi cant correlations were found between social inhibition and anhedonia before and after adjustment for depression. In women, a Sobel test indicated signifi cant mediation by social inhibition of the relationship between anhedonia and depression. Results suggested that the social inhibition component of Type D personality could constitute a poor prognosis factor.SCOPUS: ar.jinfo:eu-repo/semantics/publishe

Comment on ’Comparison of losartan and amlodipine effects on the outcomes of patient with COVID-19 and primary hypertension: A randomised clinical trial’

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