Relative Luciferase activity.

<p>Three independent assays were performed by triplicate and data represent means±SD. 24 h after transfection MUT constructs containing the +3725C variant shown lower (p = 0.0001) activity than wild-type 3′UTR construct (WT); The relative firefly Luciferase activities were normalized against β-gal.</p

Clinical characteristics for all participants, stratified by TLR4+3725G/C (rs11536889) genotype and smoking status.

a<p>Adiponectin was measured in 467 individuals.</p>b<p>Fasting insulin was measured in 730 individuals.</p><p>Differences in the continuous traits values among the genotype groups were analyzed by ANOVA (log variable transformation was performed when variables showed non normal distribution). p<0.05 is indicated by *.</p><p>BMI, body mass index; WC, waist circumference; SBP, systolic blood pressure; DBP, diastolic blood pressure; TC, total cholesterol; LDL-C, low-density lipoprotein cholesterol; HDL-C, high-density lipoprotein cholesterol; TG, triglycerides; FPG, fasting plasma glucose; HOMA-IR, homeostasis model assessment of insulin resistance.</p

Fisher’s exact test analysis between rs11536889 and bmi, stratified by smoking status.

<p>OR, odds ratio; CI, Confidence Interval. BMI, Body Mass Index.</p

Scheme of TLR4 3′UTR, indicating the sequence variants studied and its regulatory regions.

<p>Scheme of TLR4 3′UTR, indicating the sequence variants studied and its regulatory regions.</p