Assessment of changes in clinical and biochemical indicators of saliva at caries according to monitoring

<p>The research goal was to determine the variability in the salivary characteristics, depending on the season, identifying the most important indicators of the salivary characteristics at different degrees of intensity of caries process and the establishment of a correlation between these indicators. Structural characteristics of salivary pools of the students of stomatological faculty have been invented. Object of research. The salivary pools were collected at 8-9 a.m. within 1-1.5 hours after tooth cleaning. The investigation of oral cavity and the biochemical rates were marked twice: in autumn and spring. Results. The tests show, that biochemical characteristics of saliva depend on the caries involvement. It was detected, that caries involvement depends on the region, food characteristics and oral hygiene. It was proved, that saliva has buffers characteristics. Conclusion. These results can be used for explaining the molecular mechanisms of homeostasis disorders in the oral cavity and evaluating the efficiency of preventive and therapeutic measures at early stages of caries.</p

ИММУНОГЕНЕТИЧЕСКИЕ АСПЕКТЫ РАННЕГО РЕВМАТОИДНОГО АРТРИТА

The study is aimed to investigate the distribution of alleles of HLA-DRB1 gene in patients with early rheumatoid arthritis and healthy individuals in Russian population, and evaluate their significance as molecular genetic markers of rheumatoid arthritis predisposition and protection. The association between alleles of HLA-DRB1 genes, antibodies to cyclic citrullinated peptides and IgM rheumatoid factor was also studied. Low and high resolution HLA-DRB1 genotyping were compared. In the cohort of patients with early rheumatoid arthritis, the alleles of HLA-DRB1 gene were found to be markers of rheumatoid arthritis protection/risk, especially in the homozygous state. They determined production of antibodies to cyclic citrullinated peptides but were not associated with rheumatoid factor IgM levels. These findings support different autoimmune mechanisms of rheumatoid arthritis pathogenesis. Изучено распределение аллелей гена HLA-DRB1 у больных ранним ревматоидным артритом и здоровых лиц контрольной группы российской популяции и оценена их значимость в качестве молекулярно-генетических маркеров предрасположенности и протекции ревматоидного артрита. Определена сила ассоциативной связи аллелей гена HLA-DRB1 с продукцией антител к циклическим цитруллинированным пептидам и ревматоидному фактору класса М. В исследовании проведено сравнение методов высоко- и низкоразрешающего генотипирования аллелей HLA-DRB1. У больных ранним ревматоидным артритом обнаружены аллели гена HLA-DRB1, являющиеся маркерами риска и протекции ревматоидного артрита, детерминирующие продукцию антител к циклическим цитруллинированным пептидам, но не ассоциированные с антителами класса M к ревматоидному фактору. Полученные данные могут свидетельствовать о различных аутоиммунных механизмах патогенеза ревматоидного артрита. 

The Chemical Composition of Ground Water in Observational Water Vents in the Petropavlovsk Geodynamic Test Site: The Classification and Effects of Large Earthquakes

This paper considers the chemical composition and classification of ground water at seven flowing wells and four springs using materials from the 2014 hydrogeochemical sampling and from continuous observations conducted by the Kamchatka Branch of the Geophysical Survey of the Russian Academy of Sciences (KB GS RAS) in 1989–1999. We estimated the saturation of ground water discharges at individual vents with alumosilicate, carbonate, and sulfate secondary minerals, following the behavior of saturation over time. We have found that the ground water undergoes an increase in the saturation with secondary minerals during large earthquakes that produced shaking of intensity I = 5–6 on the MSK-64 scale. Such changes in the saturation of ground water with secondary minerals are less pronounced during the precursory periods before earthquake occurrence. We discuss desirable future developments of the observational system at wells and springs in order to look for new types of hydrogeochemical precursors to earthquakes

Using d2P software to create 3D models of eye orbits based on facial nerves: Historical experience

Treatment of post-traumatic defects and deformities. it continues to be an urgent medical problem. These types of facial skeleton injuries are accompanied by severe ones: Aesthetic changes caused by offset, eyeball and deformations of the contours of the orbit. Such functional disorders as diplopia, difficulty in movement of the eyeball, significantly complicate social adaptation of the victims, as well as suppressing their psychological state. © 2021, Rossiiskaya Akademiya Nauk, Institut Istorii (Russian Academy of Sciences, Institute of General Hist. All rights reserved

Complex treatment of recurrent cystitis with neurogenic bladder dysfunction in girls

[No abstract available

Cerebral structural characteristics in children with unilateral amblyopia: A mri study

Objective. To study the mechanism of the development of amblyopia using the analysis of brain grey matter parameters. The areas primarily associated with visual cortex in children with amblyopia were analyzed. Material and methods. The study group comprised 8 right-handed children with left-sided amblyopia. MRI images were obtained by 1.5T Toshiba scanner with 3D MP-RAGE. Т1-images were processed with FreeSurfer (5.3.0 version, http://surfer.nmr.mgh.harvard.edu/). Results and conclusion. No significant interhemisphere differences by cortical thickness were identified in all tested regions of interest. In correlation analysis, only the positive correlation between visual acuity in the left eye and cortical thickness in the left pericalcarine as well as the positive correlation between visual acuity in the left eye and cortical thickness in the left V1 area obtained using another anatomical atlas survived multiple comparison correction. The findings support the hypothesis that pathological ontogenetic processes in children with amblyopia lead to the structural abnormalities of the primary visual cortex. © 2018, Media Sphera Publishing Group. All Rights Reserved

The Role of Weak Interactions in Strong Intermolecular M···Cl Complexes of Coinage Metal Pyrazolates: Spectroscopic and DFT Study

The nondestructive reversible complexation of the macrocyclic group 11 metal pyrazolates {[3,5-(CF3)2Pz]M}3 (M = Cu(I), Ag(I)) to the halogen atom X = Cl, Br of η3-allyliron tricarbonyl halides (η3-2-R-C3H4)Fe(CO)3X is revealed by the variable-temperature spectroscopic (IR, NMR) study combined with density functional theory calculations. The composition of all complexes at room temperature is determined as 1:1. In the case of the [AgL]3 macrocycle, complexes 1:2 are observed at low temperature (&lt;260 K). The complex's stability depends on the substituents in the allyl fragment and halide ligand as well as on the metal atom (Ag(I), Cu(I)) in the macrocycle. For bulky substituents (Me and Ph) the endo/exo equilibrium of the parent (η3-2-R-C3H4)Fe(CO)3X shifts upon the complex formation in favor of the exo isomer due to additional noncovalent interactions of the substituent with macrocycle. © 2016 American Chemical Society