A Laminar Cortical Model for 3D Perception of Slanted and Curved Surfaces and of 2D Images: Developement, attention, and Bistability

A model of laminar visual cortical dynamics proposes how 3D boundary and surface representations of slated and curved 3D objects and 2D images arise. The 3D boundary representations emerge from interactions between non-classical horizontal receptive field interactions with intracorticcal and intercortical feedback circuits. Such non-classical interactions contextually disambiguate classical receptive field responses to ambiguous visual cues using cells that are sensitive to angles and disparity gradients with cortical areas V1 and V2. These cells are all variants of bipole grouping cells. Model simulations show how horizontal connections can develop selectively to angles, how slanted surfaces can activate 3D boundary representations that are sensitive to angles and disparity gradients, how 3D filling-in occurs across slanted surfaces, how a 2D Necker cube image can be represented in 3D, and how bistable Necker cuber percepts occur. The model also explains data about slant aftereffects and 3D neon color spreading. It shows how habituative transmitters that help to control developement also help to trigger bistable 3D percepts and slant aftereffects, and how attention can influence which of these percepts is perceived by propogating along some object boundaries.Air Force Office of Scientific Research (F49620-01-1-0397, F49620-98-1-0108); Defense Advanced Research Projects Agency and the Office of Naval Research (N0014-95-1-0409, N00014-01-1-0624, N00014-95-1-0657); National Science Foundation (IIS-97-20333

Arithmetic Operations in Multi-Valued Logic

This paper presents arithmetic operations like addition, subtraction and multiplications in Modulo-4 arithmetic, and also addition, multiplication in Galois field, using multi-valued logic (MVL). Quaternary to binary and binary to quaternary converters are designed using down literal circuits. Negation in modular arithmetic is designed with only one gate. Logic design of each operation is achieved by reducing the terms using Karnaugh diagrams, keeping minimum number of gates and depth of net in to consideration. Quaternary multiplier circuit is proposed to achieve required optimization. Simulation result of each operation is shown separately using Hspice.Comment: 12 Pages, VLSICS Journal 201

Bayesian State Space Modeling of Physical Processes in Industrial Hygiene

Exposure assessment models are deterministic models derived from physical-chemical laws. In real workplace settings, chemical concentration measurements can be noisy and indirectly measured. In addition, inference on important parameters such as generation and ventilation rates are usually of interest since they are difficult to obtain. In this paper we outline a flexible Bayesian framework for parameter inference and exposure prediction. In particular, we propose using Bayesian state space models by discretizing the differential equation models and incorporating information from observed measurements and expert prior knowledge. At each time point, a new measurement is available that contains some noise, so using the physical model and the available measurements, we try to obtain a more accurate state estimate, which can be called filtering. We consider Monte Carlo sampling methods for parameter estimation and inference under nonlinear and non-Gaussian assumptions. The performance of the different methods is studied on computer-simulated and controlled laboratory-generated data. We consider some commonly used exposure models representing different physical hypotheses

Salivary levels of anti-tuberculosis drugs

The study deals with monitoring of isoniazid and rifampicin levels in saliva compared with that in serum because of various advantages including convenience and non-invasive nature of the former procedure

Effects of Highlights on Gloss Perception

The perception of a glossy surface in a static monochromatic image can occur when a bright highlight is embedded in a compatible context of shading and a bounding contour. Some images naturally give rise to the impression that a surface has a uniform reflectance, characteristic of a shiny object, even though the highlight may only cover a small portion of the surface. Nonetheless, an observer may adopt an attitude of scrutiny in viewing a glossy surface, whereby the impression of gloss is partial and nonuniform at image regions outside of a higlight. Using a rating scale and small probe points to indicate image locations, differential perception of gloss within a single object is investigate in the present study. Observers' gloss ratings are not uniform across the surface, but decrease as a function of distance from highlight. When, by design, the distance from a highlight is uncoupled from the luminance value at corresponding probe points, the decrease in rated gloss correlates more with the distance than with the luminance change. Experiments also indicate that gloss ratings change as a function of estimated surface distance, rather than as a function of image distance. Surface continuity affects gloss ratings, suggesting that apprehension of 3D surface structure is crucial for gloss perception.Air Force Office of Scientific Research (F49620-98-1-0108), Defense Advanced Research Projects Agency and the Office of Naval Research (N00014-95-1-0409), National Science Foundation (IIS-97-20333); Office of Naval Research (N00014-95-1-0657, N00014-01-1-0624); Whitaker Foundation (RG-99-0186

MECHANISM OF CANCER SELECTIVE APOPTOSIS BY PAR-4

Despite distinct dissimilarities, diverse cancers express several common pro-tumorigenic traits. We present here evidence that the pro-apoptotic protein Par-4 utilizes one such common tumorigenic trait to become selectively activated and induce apoptosis in cancer cells. Elevated PKA activity noted in cancer cells activated the apoptotic function of ectopic Par-4 or its SAC domain, which induces apoptosis selectively in cancer cells and not in normal or immortalized cells. PKA preferentially phosphorylated Par-4 at the T155 residue within the SAC domain in cancer cells. Moreover, pharmacological-, peptide- or siRNA-mediated inhibition of PKA activity in cancer cells resulted in abrogation of both T155 phosphorylation and apoptosis by Par-4. The mechanism of activation of endogenous Par-4 was similar to that of ectopic Par-4, and in response to exogenous stimuli, endogenous Par-4 induced apoptosis by a PKA and phospho-T155 dependent mechanism. Enforced elevation of PKA activity in normal cells resulted in apoptosis by the SAC domain of Par-4 in a T155-dependent manner. Together, these observations suggest that selective apoptosis of cancer cells by the SAC domain of Par-4 involves phosphorylation of T155 by PKA. These findings uncover a novel mechanism engaging PKA, a pro-cancerous activity commonly elevated in most tumor cells, to activate the cancer selective apoptotic action of Par-4

I. Generation of dibromocarbene under neutral conditions; II. Generation and reactions of 11-carbena[4.4.1]propella-3,8-diene; III. The oxidation of cyclopropylidenes

Most of the methods of generation of dihalocarbenes involve basic media which are not ideal for reactions with compounds containing base-sensitive groups like -OAc. In an effort to generate:CBr[subscript]2 under neutral conditions, we explored the thermolysis and photolysis of 10,10-dibromotricyclo (4.3.1.0) deca-2,4-diene. Both methods generated:CBr[subscript]2 in good yields, as evidenced by the formation of dibromocyclopropane adducts with olefins like 2-pentene and cyclohexene;In an effort to study whether the tricyclic carbene, 11-carbena (4.4.1) propella-3,8-diene, ring opens to the corresponding allene, we generated the free carbene by LiOCH[subscript]3 decomposition of N-Nitroso-N- (4.4.1) -propella-3,8-dienyl-11-urea. Analysis of the product mixture did not indicate any allene derived product. In the course of this study we postulated a methanol induced ring opening of cyclopropyl diazonium ion to a diazo compound and discovered an unusual regioselectivity of nitrosation of norcarane ureas;Oxidation of carbenes with molecular oxygen yields intermediates such as carbonyl oxides and dioxiranes. These intermediates were orginally postulated in ozonolysis of alkenes. In recent years, many of these intermediates, prepared by the oxidation of carbenes and modified Baeyer-Villiger oxidation of ketones, have been studied spectroscopically (UV, IR, [superscript]1H NMR). In view of this, and based on the results of the oxidation of cyclopropyllithiums, we undertook a study of the oxidation of lithiumhalocyclopropanes (cyclopropylidenes). Low temperature [superscript]13C NMR study of this oxidation showed evidence for carbonyl oxide, dioxirane and bromoperoxylithium intermediates. Ours is the first report of [superscript]13C NMR spectra of carbonyl oxides and also coexistence of dioxiranes and carbonyl oxides in solution. The intermediates were also trapped by reagents such as n-BuLi and methanol

Self-stabilizing network orientation algorithms in arbitrary rooted networks

Network orientation is the problem of assigning different labels to the edges at each processor, in a globally consistent manner. A self-stabilizing protocol guarantees that the system will arrive at a legitimate state in finite time, irrespective of the initial state of the system. Two deterministic distributed network orientation protocols on arbitrary rooted, asynchronous networks are proposed in this work. Both protocols set up a chordal sense of direction in the network. The protocols are self-stabilizing, meaning that starting from an arbitrary state, the protocols are guaranteed to reach a state in which every processor has a valid node label and every link has a valid edge label. The first protocol assumes an underlying depth-first token circulation protocol; it orients the network as the token is passed among the nodes and stabilizes in O(n) steps after the token circulation stabilizes, where n is the number of processors in the network. The second protocol is designed on an underlying spanning tree protocol and stabilizes in O(h) time, after the spanning tree is constructed, where h is the height of the spanning tree. Although the second protocol assumes the existence of a spanning tree of the rooted network, it orients all edges--both tree and non-tree edges--of the network

Reimagining teacher professional development : communities of practice

Communities of practice (COP) are groups of people who share a concern or passion for something they do, and learn how to do it better as they interact regularly. The presentation broadly covers how to facilitate new learning methods through teacher forums as a community of practice in India