Haplotype association of seven significant SNPs from <i>BUD13</i>- <i>ZNF259</i>, <i>A5-A4-C3-A1</i>, and <i>SIK3</i> cluster with TG.

<p>rs7350481; rs180326; rs964184; rs12286037; rs618923; rs10047459; rs533556; *Empirical p = 9.0×10⁻⁴; ^†Empirical p = 0.034; *adjusted for age, gender, and BMI.</p

Test of independence: step-wise multiple linear regression showing association of SNPs with TG using full model^‡.

‡<p>Includes age, BMI, gender, disease, and rs7350481, rs180326, rs12286037, rs964184, rs618923, rs10047459, rs533556 in the model.</p

Association of six most significant SNPs within <i>BUD13</i>-<i>ZNF259</i>, <i>A5-A4-C3-A1</i>, and <i>SIK3</i> with TG.

<p>Genotyping on rs12286037 was not available in LOLIPOP sample.</p

Shows the distribution of serum triglyceride levels in Punjabi, US and entire cohort stratified by rs964184 genotypes.

<p>Multiple linear regression analysis was performed using age, BMI and gender in individuals cohorts and age, BMI, gender and place of birth as combined cohorts. <i>P</i>-values in the bars show statistically significant association of ‘G’ risk allele with triglycerides.</p

Location of genetic markers in chromosomal region (11q23.3) (195 Kb) encompassing <i>BUD13-ZNF259, APOA5-A4-C3-A1,</i> and <i>SIK3</i> gene cluster.

<p>Exons are shown in black vertical rectangles separated by introns. Significant SNPs (associated with increased triglyceride concentrations) detected in <i>BUD13</i>, <i>ZNF259</i> and <i>SIK3</i> are shown in large rectangles on disequilibrium (LD) matrix with their position on the genes indicated by lines. The direction of transcription of genes is shown in arrows. Pair-wise LD between SNPs (D’) is indicated by diamonds shaded in white-grey-black show the range of LD matrix from D’ = 0 in white to D’ = 1 in black. LD block 1 contains 5 most significant SNPs including two top SNPs (rs964184 and rs7350481) of the total 45 analyzed. LD block 2 shows all SNPs from <i>the SIK3</i> gene and the presence of a strong LD among these SNPs containing two strong signals associated with triglycerides in rs10047459 and rs533556.</p

Association of significant SNPs with lipid traits in the SDS cohort.

<p>Association of significant SNPs with lipid traits in the SDS cohort.</p

Details of the investigated loci.

*<p>fonts in bold indicate risk allele.</p

Characteristics of participants in the LOLIPOP Study.

<p>Characteristics of participants in the LOLIPOP Study.</p

Known WHR SNPs.

<p><b>(A) Comparison of risk allele frequencies in South Asians (N = 10,318) and Europeans (reported). (B) Comparison of effect sizes (β WHR) in South Asians and Europeans.</b> Green–men and women combined (37 SNPs in South Asians (N = 10,318) and Europeans (reported)); orange–women alone (11 SNPs in South Asians (N = 1,463) and Europeans (reported)).</p

Study Design.

<p>Study Design.</p