Exploring Socio-Cultural Perspectives on Diversity

This Grants Collection uses the grant-supported open textbook OpenEDUC from the University of Georgia: http://oer.galileo.usg.edu/education-textbooks/4 This Grants Collection for Critical and Contemporary Issues in Education was created under a Round Two ALG Textbook Transformation Grant. Affordable Learning Georgia Grants Collections are intended to provide faculty with the frameworks to quickly implement or revise the same materials as a Textbook Transformation Grants team, along with the aims and lessons learned from project teams during the implementation process. Documents are in .pdf format, with a separate .docx (Word) version available for download. Each collection contains the following materials: Linked Syllabus Initial Proposal Final Reporthttps://oer.galileo.usg.edu/education-collections/1000/thumbnail.jp

Reply to Bone mineral density in young adult survivors of acute lymphoblastic leukemia

No abstract.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/64309/1/24456_ftp.pd

Critical and Contemporary Issues in Education

This Grants Collection uses the grant-supported open textbook OpenEDUC from the University of Georgia: http://oer.galileo.usg.edu/education-textbooks/4 This Grants Collection for Critical and Contemporary Issues in Education was created under a Round Two ALG Textbook Transformation Grant. Affordable Learning Georgia Grants Collections are intended to provide faculty with the frameworks to quickly implement or revise the same materials as a Textbook Transformation Grants team, along with the aims and lessons learned from project teams during the implementation process. Documents are in .pdf format, with a separate .docx (Word) version available for download. Each collection contains the following materials: Linked Syllabus Initial Proposal Final Reporthttps://oer.galileo.usg.edu/education-collections/1001/thumbnail.jp

Integrating Brain and Biomechanical Models—A New Paradigm for Understanding Neuro-muscular Control

To date, realistic models of how the central nervous system governs behavior have been restricted in scope to the brain, brainstem or spinal column, as if these existed as disembodied organs. Further, the model is often exercised in relation to an in vivo physiological experiment with input comprising an impulse, a periodic signal or constant activation, and output as a pattern of neural activity in one or more neural populations. Any link to behavior is inferred only indirectly via these activity patterns. We argue that to discover the principles of operation of neural systems, it is necessary to express their behavior in terms of physical movements of a realistic motor system, and to supply inputs that mimic sensory experience. To do this with confidence, we must connect our brain models to neuro-muscular models and provide relevant visual and proprioceptive feedback signals, thereby closing the loop of the simulation. This paper describes an effort to develop just such an integrated brain and biomechanical system using a number of pre-existing models. It describes a model of the saccadic oculomotor system incorporating a neuromuscular model of the eye and its six extraocular muscles. The position of the eye determines how illumination of a retinotopic input population projects information about the location of a saccade target into the system. A pre-existing saccadic burst generator model was incorporated into the system, which generated motoneuron activity patterns suitable for driving the biomechanical eye. The model was demonstrated to make accurate saccades to a target luminance under a set of environmental constraints. Challenges encountered in the development of this model showed the importance of this integrated modeling approach. Thus, we exposed shortcomings in individual model components which were only apparent when these were supplied with the more plausible inputs available in a closed loop design. Consequently we were able to suggest missing functionality which the system would require to reproduce more realistic behavior. The construction of such closed-loop animal models constitutes a new paradigm of computational neurobehavior and promises a more thoroughgoing approach to our understanding of the brain’s function as a controller for movement and behavior

Waist circumference percentile thresholds for identifying adolescents with insulin resistance in clinical practice

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/72493/1/j.1399-5448.2008.00474.x.pd

Evolving antibiotics against resistance : a potential platform for natural product development?

To avoid an antibiotic resistance crisis, we need to develop antibiotics at a pace that matches the rate of evolution of resistance. However, the complex functions performed by antibiotics—combining, e.g., penetration of membranes, counteraction of resistance mechanisms, and interaction with molecular targets— have proven hard to achieve with current methods for drug development, including target-based screening and rational design. Here, we argue that we can meet the evolution of resistance in the clinic with evolution of antibiotics in the laboratory. On the basis of the results of experimental evolution studies of microbes in general and antibiotic production in Actinobacteria in particular, we propose methodology for evolving antibiotics to circumvent mechanisms of resistance. This exploits the ability of evolution to find solutions to complex problems without a need for design. We review evolutionary theory critical to this approach and argue that it is feasible and has important advantages over current methods for antibiotic discovery

Twenty-one days of spirulina supplementation lowers heart rate during submaximal cycling and augments power output during repeated sprints in trained cyclists

Spirulina supplementation is reported to improve time to exhaustion and V̇O2max. However, there is limited information on its influence over the multiple intensities cyclists experience during training and competition. Fifteen trained males (Age 40 ± 8 years, V̇O2max 51.14 ± 6.43 ml/min/kg) ingested 6g/day of spirulina or placebo for twenty-one days in a double-blinded randomized cross over design, with a fourteen-day washout period between trials. Participants completed a 1-hour submaximal endurance test at 55% external power output max and a 16.1km time trial (day 1), followed by a lactate threshold test and repeated sprint performance tests (RSPTs) (day 2). Heart rate (bpm), Respiratory Exchange Ratio, oxygen consumption (ml/min/kg), lactate and glucose (mmol/L), time (secs), power output (Watts), and hemoglobin (g/L) were compared across conditions. Following spirulina supplementation, lactate and heart rate were significantly lower (P0.05). Spirulina supplementation reduces homeostatic disturbances during submaximal exercise and augments power output during RSPTs.Novelty bullets:• Spirulina supplementation lowers heart rate and blood lactate during ≈1-hour submaximal cycling. • Spirulina supplementation elicits significant augmentations in hemoglobin and power outputs during RSPTs