A novel glucose sensor using lutetium phthalocyanine as redox mediator in reduced graphene oxide conducting polymer multifunctional hydrogel

Herein, we report a scalable synthesis of multifunctional conducting polyacrylic acid (PAA) hydrogel (MFH) integrated with reduced grapheme oxide (rGO), vinyl substituted polyaniline (VS-PANI) and lutetium Phthalocyanine (LuPc2) as three dimensional robust matrix for glucose oxidase (GOx) immobilization (PAA-rGO/VS-PANI/LuPc2/GOx-MFH). We have integrated the multicomponents such as PAA with rGO, and VS-PANI through free radical polymerization using methylene bis-acrylamide, and ammonium persulphate as the cross linker and initiator. The LuPc2 was then doped to form multifunctional hydrogel (PAA-rGO/VS-PANI/LuPc2-MFH). Finally, biosensor was fabricated by immobilizing GOx into PAA-rGO/VS-PANI/LuPc2-MFH and subsequently used for electrochemical detection of glucose. The PAA-rGO/VS-PANI/LuPc2/GOx-MFH biosensor exhibited high sensitivity (15.31 μA mM−1 cm−2) for the detection of glucose over a concentration range of 2–12 mM with a low detection limit of 25 µm. The PAA-rGO/VS-PANI/LuPc2-MFH biosensor showed a fast response time (1 s) to the addition of glucose with high storage stability of 3 months. The real sample analysis reveals that PAA-rGO/VS-PANI/LuPc2/GOx-MFH could be effectively used as an electrochemical biosensor in industrial as well clinical diagnosis

Encapsulation of a zinc phthalocyanine derivative in self-assembled peptide nanofibers

Cataloged from PDF version of article.In this article, we demonstrate encapsulation of octakis(hexylthio) zinc phthalocyanine molecules by non-covalent supramolecular organization within self-assembled peptide nanofibers. Peptide nanofibers containing octakis(hexylthio) zinc phthalocyanine molecules were obtained via a straight-forward one-step self-assembly process under aqueous conditions. Nanofiber formation results in the encapsulation and organization of the phthalocyanine molecules, promoting ultrafast intermolecular energy transfer. The morphological, mechanical, spectroscopic and non-linear optical properties of phthalocyanine containing peptide nanofibers were characterized by TEM, SEM, oscillatory rheology, UV-Vis, fluorescence, ultrafast pump-probe and circular dichroism spectroscopy techniques. The ultrafast pump-probe experiments of octakis(hexylthio) zinc phthalocyanine molecules indicated pH controlled non-linear optical characteristics of the encapsulated molecules within self-assembled peptide nanofibers. This method can provide a versatile approach for bottom-up fabrication of supramolecular organic electronic devices. © 2012 The Royal Society of Chemistry

Design of a Gd-DOTA-Phthalocyanine Conjugate Combining MRI Contrast Imaging and Photosensitization Properties as a Potential Molecular Theranostic

Cataloged from PDF version of article.The design and synthesis of a phthalocyanine - Gd-DOTA conjugate is presented to open the way to novel molecular theranostics, combining the properties of MRI contrast imaging with photodynamic therapy. The rational design of the conjugate integrates isomeric purity of the phthalocyanine core substitution, suitable biocompatibility with the use of polyoxo water-solubilizing substituents, and a convergent synthetic strategy ended by the use of click chemistry to graft the Gd-DOTA moiety to the phthalocyanine. Photophysical and photochemical properties, contrast imaging experiments and preliminary in vitro investigations proved that such a combination is relevant and lead to a new type of potential theranostic agent

Preparation of iron phthalocyanine complex bearing four tetraazamacrocycles as a precursor for oxidation catalyst with two catalytic sites

Isci, Uemit Gurek, Ayse Guel Ahsen, Vefa Sorokin, Alexander B.The synthesis of the iron phthalocyanine bearing four fused tetraaza macrocycles starting from N,N',N '',N'''-tetrakis(p-tolylsulfonyl)triethylenetetraamine and 1,2-dibromo-4,5-bis-(bromomethyl) benzene is reported. The exchange of protecting tosyl groups by acetyl groups was necessary to obtain iron phthalocyanine. The efficiency of iron phthalocyanine as oxidation catalyst was tested for the practically important oxidation of 2,3,6-trimethylphenol (TMP) at different reaction conditions

Optical detection of pentachlorophenol in water using thin films of octa-tosylamido substituted zinc phthalocyanine

In this work, thin films of eight octasubstituted zinc(II) phthalocyanine derivative (ZnPcR8) with tosylamido substituents R = –NHSO2(C6H4)CH3 were investigated as active layer of optical sensors for the detection of pentachlorophenol. Using total internal reflection ellipsometry (TIRE) technique response characteristics of ZnPcR8 films to pentachlorophenol were studied in the concentration range from 0.1 to 20 μg/l. This was also validated for natural river and wastewater samples. It was demonstrated that the specific binding of pentachlorophenol molecules causes substantial shift of Δ(λ) spectrum. The minimum registered concentration of pentachlorophenol was 0.7 μg/l. For the river water and wastewater samples the detection limits as well as a working concentration ranges showed no significant difference with respect to those found in distilled water

Effect of Interface on the Orientation of the Liquid Crystalline Nickel Phthalocyanine Films

In this paper, the effect of interface oil the orientation of the film of two derivatives of tetra-substituted nickel phthalocyanines NiPcR4-1 (R = -OCH(CH2OC12H25)(2)) and NiPcR4-2 (R = -SCH(CH2(C1CH2CH2)(2)OC2H5)(2)) deposited oil one substrate and between two identical substrates is studied by the method of polarized Raman spectroscopy The methods of ultraviolet-visible (UV-vis) absorption spectroscopy and infrared (IR) spectroscopy were also used for the characterization of films deposited oil quartz and KBr substrates, respectively. The orientation of columns in films confined between two substrates is characterized by polarized optical microscopy It has been shown that the films of both compounds confined between two substrates are characterized by homeotropic alignment while no homeotropic alignments could be obtained with an air interface. The orientation is also independent of the type of substituents on the phthalocyanine ring

Investigation of gas-sensing properties of copper phthalocyanine films

In this work, the sensor response of thin films of octasubstituted copper phthalocyanine derivative (CuPcR8) with bulky substituents on R = -N(SO2C6H5-CH3)CH2(CH2)(8)CH3 to the vapour of benzene, chloroform, ethanol and butanol were investigated by surface plasmon resonance technique. The application and some advantages of total internal reflection ellipsometry method for determination of the organic vapours are also demonstrated. (C) 2008 Elsevier B.V. All rights reserved

Phthalocyanine films as active layers of optical sensors for pentachlorophenol detection

In this work, thin films of octasubstituted zinc phthalocyanine derivative (ZnPcR8) with bulky substituents R=-CH2N(SO2C6H5-CH3)CH2(CH2)(8)CH3 are investigated as active layers of optical sensors for the detection of pentachlorophenol. Using total internal reflection ellipsometry (TIRE) technique response characteristics of ZnPcR8 films to pentachlorophenol was studied in the concentration range 0.5-50 mu g/l. It was demonstrated that the specific binding of pentachlorophenol molecules causes substantial shift of Delta(lambda) spectrum. The minimum registered concentration of pentachlorophenol was 0.8 mu g/l. The results are supported by performing attenuated total reflection Fourier transform infrared (ATR-FTIR) difference spectroscopy. (C) 2009 Elsevier B.V. All rights reserved

Liquid crystalline phthalocyanine spun films for organic vapour sensing

Vapour sensing properties of spin-coated films of mesogenic octa-substituted phthalocyanine derivatives MPcR8, where M=Ni(II). R=-S(CH2)(11)CH3, -SCH(CH2OC12H25)(2), -S(CH2CH2O)(3)CH3 were investigated using spectroscopic ellipsometry, Raman spectroscopy and surface plasmon resonance (SPR) technique. Solvent molecules with saturated C-C bonds such as chloroform are found to have formed hydrogen bonds with alkyl chains of the substituents of phthalocyanine molecules. The sensor response to aromatic compounds such as benzene is, on the other hand, believed to be the consequence of their pi-pi interaction with the conjugated phthalocyanine ring. (c) 2005 Elsevier B.V. All rights reserved

Investigation of liquid-crystalline behaviour of copper octakisalkylthiophthalocyanine and its film properties

The mesogenic properties of copper octakisalkylthiophthalocyanine [(C6S)(8)PcCu] were studied by differential scanning calorimetry (DSC), Xray and optical microscopy. This phthalocyanine forms columnar hexagonal (Col(h)) mesophase. Thin films of (C6S)(8)PcCu were prepared by spin-coating technique. Thermally induced molecular reorganization within the films was studied by the methods of ellipsometry and UV-Vis absorption spectroscopy. Heat treatment produces molecular ordering which is believed to be due to stacking interaction between neighbouring phthalocyanine moieties. The differences in structural organization of the heated and unheated films were stated. These differences in structural organization in their turn are found to influence the electrical properties of the films. (c) 2007 Elsevier B.V. All rights reserved