Wrongful life claims and negligent selection of gametes or embryos in infertility treatments: a quest for coherence.

This article discusses an anomaly in the English law of reproductive liability: that is, an inconsistency between the law's approach to wrongful life claims and its approach to cases of negligent selection of gametes or embryos in infertility treatments (the selection cases). The article begins with an account of the legal position, which brings into view the relevant inconsistency: while the law treats wrongful life claims as non-actionable, it recognises a cause of action in the selection cases, although the selection cases bear a relevant resemblance to wrongful life claims. The article then considers arguments that may be invoked in an attempt to reconcile the above two strands of the law. Three of these counterarguments consist in attempts to distinguish the selection cases from wrongful life claims. It is argued that these attempts fail to reveal a valid basis for treating these situations differently. A fourth possible counterargument levels against the present analysis a charge of reductio ad absurdum. It is shown that this argument suffers from a fundamental flaw caused by confusion between different senses of the term "identity". Finally, the article discusses possible changes to the legal position that could rectify the problem. It argues that one of these changes, which focuses on legal redress for violation of personal autonomy, is particularly apt to resolve the problem at hand, but also highlights the need for further inquiry into the broader implications of introducing this form of redress into the law of torts

Legal Rules as a Bias-Counteracting Device

In this paper, I argue that one of the key aspects of law’s conduct-guiding role is to serve as a corrective device against several systematic biases present in the settings of activity that law typically regulates. Following a few preliminary remarks (Section 1), I home in on the relevant problems of bounded rationality, drawing, inter alia, on empirical literature in psychology (Section 2). I highlight several systematic biases and explain how law is structurally suited to counteract some of their instantiations in social life. I discuss several doubts emerging from the fallibility of law and from the prospect of debiasing oneself of one’s own accord (Subsection 2.2. and Section 3). Finally , I consider some of the implications of my claim (Section 4)

Faster Family-wise Error Control for Neuroimaging with a Parametric Bootstrap

In neuroimaging, hundreds to hundreds of thousands of tests are performed across a set of brain regions or all locations in an image. Recent studies have shown that the most common family-wise error (FWE) controlling procedures in imaging, which rely on classical mathematical inequalities or Gaussian random field theory, yield FWE rates that are far from the nominal level. Depending on the approach used, the FWER can be exceedingly small or grossly inflated. Given the widespread use of neuroimaging as a tool for understanding neurological and psychiatric disorders, it is imperative that reliable multiple testing procedures are available. To our knowledge, only permutation joint testing procedures have been shown to reliably control the FWER at the nominal level. However, these procedures are computationally intensive due to the increasingly available large sample sizes and dimensionality of the images, and analyses can take days to complete. Here, we develop a parametric bootstrap joint testing procedure. The parametric bootstrap procedure works directly with the test statistics, which leads to much faster estimation of adjusted \emph{p}-values than resampling-based procedures while reliably controlling the FWER in sample sizes available in many neuroimaging studies. We demonstrate that the procedure controls the FWER in finite samples using simulations, and present region- and voxel-wise analyses to test for sex differences in developmental trajectories of cerebral blood flow

Growth rate of Scenedesmus acutus in laboratory cultures exposed to diazinon

The effects of the pesticide, diazinon on growth rate was examined in unialgal cultures of freshwater green algae, Scenedesmus acutus through 96 h acute toxicity tests. S. acutus was exposed to different concentrations of diazinon (1, 2, 4, 8, 16 and 32 μl) in the laboratory maintained at 23 ± 1°C and 16:8 light : dark regime. Cell numbers were determined daily and growth rates were calculated for a period of 4 days. The growth rate of S. acutus in the control cultures was higher at 0 to 4 days (40.000 to 276600 individuals), but the growth rate of the treated cultures with diazinon decreased at 2 to 4 days (28000 to 10320 individuals). The results demonstrated adverse effects of diazinon on freshwater green algae (S. acutus). Thus, the application of this pesticide for pest control in agriculture must be done carefully since any disturbance affecting algae with similar or higher sensitivity will have severe repercussions on higher trophic levels.Key words: Acute toxicity, algae, diazinon, growth rate, Scenedesmus acutus

Memory-delineated subtypes of schizophrenia: Relationship to clinical, neuroanatomical, and neurophysiological measures.

Memory performance was examined in patients with schizophrenia to determine whether subgroups conforming to cortical and subcortical dementias could be identified and, if so, whether subgroups differed on clinical, neuroanatomical, and neurophysiological measures. A cluster analysis of California Verbal Learning Test performance classified patients into 3 subgroups. Two groups exhibited memory deficits consistent with the cortical–subcortical distinction, whereas 1 group was unimpaired. Cortical patients tended to be male, and they had earlier illness onset, reduced temporal lobe gray matter, and hypometabolism. Subcortical patients had ventricular enlargement and more negative symptoms. Unimpaired patients had fewer negative symptoms and dorsal medial prefrontal hypermetabolism. The authors con-clude that categorizing patients on the basis of memory deficits may yield neurobiologically meaningful disease subtypes. There is increasing consensus that Kraepelin’s conceptu-alization of schizophrenia as a disorder characterized by disturbed cognition rather than psychotic symptomatology was fundamentally correct (see Sharma & Harvey, 2000, fo

Screening of anxiety and quality of life in people with epilepsy.

PURPOSE: Up to 60% of people with epilepsy (PwE) have psychiatric comorbidity including anxiety. Anxiety remains under recognized in PwE. This study investigates if screening tools validated for depression could be used to detect anxiety disorders in PWE. Additionally it analyses the effect of anxiety on QoL. METHOD: 261 participants with a confirmed diagnosis of epilepsy were included. Neurological Disorders Depression Inventory for Epilepsy (NDDI-E) and Emotional Thermometers (ET), both validated to screen for depression were used. Hospital Anxiety and Depression Scale-Anxiety (HADS-A) with a cut off for moderate and severe anxiety was used as the reference standard. QoL was measured with EQ5-D. Sensitivity, specificity, positive and negative predictive value and ROC analysis as well as multivariate regression analysis were performed. RESULTS: Patients with depression (n=46) were excluded as multivariate regression analysis showed that depression was the only significant determinant of having anxiety in the group. Against HADS-A, NDDI-E and ET-7 showed highest level of accuracy in recognizing anxiety with ET7 being the most effective tool. QoL was significantly reduced in PwE and anxiety. CONCLUSION: Our study showed that reliable screening for moderate to severe anxiety in PwE without co-morbid depression is feasible with screening tools for depression. The cut off values for anxiety are different from those for depression in ET7 but very similar in NDDI-E. ET7 can be applied to screen simultaneously for depression and "pure" anxiety. Anxiety reduces significantly QoL. We recommend screening as an initial first step to rule out patients who are unlikely to have anxiety