Hypomagnesaemia in cystic fibrosis patients referred for lung transplant assessment

AbstractBackgroundHypomagnesaemia in patients with cystic fibrosis (CF) is underrecognized although the true incidence is unknown. Many patients are asymptomatic, although severe deficiency may be associated with muscle weakness, cramps and tetany. Hypomagnesaemia may be a risk factor for post-transplant complications including convulsions, which may be exacerbated by the use of calcineurin inhibitors. The aims of the present study were to describe serum magnesium levels and to investigate the relationship between magnesium levels and age, and renal function measurements in patients with CF referred to a transplant centre for lung transplant assessment.MethodsWe reviewed the data of all 106 CF patients referred for transplant assessment from January 1995 to December 2003. Demographic and biochemical data were recorded and the explanatory variables were subjected to univariate analysis and linear regression analysis.ResultsMean serum magnesium level was 0.75 mmol/L (range 0.46–1.03, normal range 0.74–1.1). 57% of patients had hypomagnesaemia. Serum magnesium levels were not associated with age, serum creatinine or GFR.ConclusionsHypomagnesaemia is a common finding in patients with CF referred for lung transplant assessment. Serum magnesium levels should be monitored in all CF patients being referred for lung transplant irrespective of the results of other renal function tests

The shape of the CMB lensing bispectrum

Lensing of the CMB generates a significant bispectrum, which should be detected by the Planck satellite at the 5-sigma level and is potentially a non-negligible source of bias for f_NL estimators of local non-Gaussianity. We extend current understanding of the lensing bispectrum in several directions: (1) we perform a non-perturbative calculation of the lensing bispectrum which is ~10% more accurate than previous, first-order calculations; (2) we demonstrate how to incorporate the signal variance of the lensing bispectrum into estimates of its amplitude, providing a good analytical explanation for previous Monte-Carlo results; and (3) we discover the existence of a significant lensing bispectrum in polarization, due to a previously-unnoticed correlation between the lensing potential and E-polarization as large as 30% at low multipoles. We use this improved understanding of the lensing bispectra to re-evaluate Fisher-matrix predictions, both for Planck and cosmic variance limited data. We confirm that the non-negligible lensing-induced bias for estimation of local non-Gaussianity should be robustly treatable, and will only inflate f_NL error bars by a few percent over predictions where lensing effects are completely ignored (but note that lensing must still be accounted for to obtain unbiased constraints). We also show that the detection significance for the lensing bispectrum itself is ultimately limited to 9 sigma by cosmic variance. The tools that we develop for non-perturbative calculation of the lensing bispectrum are directly relevant to other calculations, and we give an explicit construction of a simple non-perturbative quadratic estimator for the lensing potential and relate its cross-correlation power spectrum to the bispectrum. Our numerical codes are publicly available as part of CAMB and LensPix.Comment: 32 pages, 10 figures; minor changes to match JCAP-accepted version. CMB lensing and primordial local bispectrum codes available as part of CAMB (http://camb.info/

Goodness-of-Fit Tests to study the Gaussianity of the MAXIMA data

Goodness-of-Fit tests, including Smooth ones, are introduced and applied to detect non-Gaussianity in Cosmic Microwave Background simulations. We study the power of three different tests: the Shapiro-Francia test (1972), the uncategorised smooth test developed by Rayner and Best(1990) and the Neyman's Smooth Goodness-of-fit test for composite hypotheses (Thomas and Pierce 1979). The Smooth Goodness-of-Fit tests are designed to be sensitive to the presence of ``smooth'' deviations from a given distribution. We study the power of these tests based on the discrimination between Gaussian and non-Gaussian simulations. Non-Gaussian cases are simulated using the Edgeworth expansion and assuming pixel-to-pixel independence. Results show these tests behave similarly and are more powerful than tests directly based on cumulants of order 3, 4, 5 and 6. We have applied these tests to the released MAXIMA data. The applied tests are built to be powerful against detecting deviations from univariate Gaussianity. The Cholesky matrix corresponding to signal (based on an assumed cosmological model) plus noise is used to decorrelate the observations previous to the analysis. Results indicate that the MAXIMA data are compatible with Gaussianity.Comment: MNRAS, in pres

Effectiveness of a participatory physical and psychosocial intervention to balance the demands and resources of industrial workers: A cluster-randomized controlled trial

Objectives The aim of this study was to evaluate the effectiveness of a participatory physical and psychosocial workplace intervention (known as PIPPI) on work ability and recovery among industrial workers. Methods Eligible workers were cluster-randomized into intervention (N=193) and control (N=222) groups. Intervention group members participated in three workshops where they mapped positive and negative aspects of their physical and psychosocial work environment and developed action plans addressing the highlighted issues, which were subsequently implemented by the participants. Questionnaire-based data on work ability and recovery were collected at baseline and 8-, 10- and 12-month follow-up. Data on productivity, well-being, mental health, and physical demands and resources were collected at baseline and 12-month follow-up. Results The intervention was delivered and received as planned (100% planned workshops conducted, 69% [standard deviation (SD) 7%] participation in workshops) and with a response rate of 76% (SD 8%) to the questionnaires. No significant between-group improvements for any of the outcomes were found in intention-to-treat multi-level mixed models. On the contrary, tendencies were observed for poorer recovery and reduced work ability in the intervention compared to control group. Conclusion The intervention did not improve the outcomes. This result can have several explanations, such as a regression-toward-the-mean effect or that the intervention might have put an additional burden on the workers already facing high work demands. In addition, there may have been an insufficient match between the intervention components implemented and the predetermined outcomes, and implementation may have been unsuccessful. These potential explanations need to be investigated using process evaluation data

A numerical reinvestigation of the Aoki phase with N_f=2 Wilson fermions at zero temperature

We report on a numerical reinvestigation of the Aoki phase in lattice QCD with two flavors of Wilson fermions where the parity-flavor symmetry is spontaneously broken. For this purpose an explicitly symmetry-breaking source term $h\bar{\psi} i \gamma_{5} \tau^{3}\psi$ was added to the fermion action. The order parameter $$ was computed with the Hybrid Monte Carlo algorithm at several values of $(\beta,\kappa,h)$ on lattices of sizes $4^4$ to $12^4$ and extrapolated to $h=0$. The existence of a parity-flavor breaking phase can be confirmed at $\beta=4.0$ and 4.3, while we do not find parity-flavor breaking at $\beta=4.6$ and 5.0.Comment: 8 pages, 5 figures, Revised version as to be published in Phys.Rev.

A Diagnostic Study on Livestock Production System in Eastern Region of India

A study was conducted in seven East Indian states, viz. Bihar, West Bengal, Odisha, Chhattisgarh, Jharkhand, Assam and eastern UP, to understand the livestock production and management systems for making strategies for the improving livestock production scenario in the region. The data were collected from two districts from each state and from each district twenty-five (25) farmers were selected. Information was collected farmer‘s socio-economic status like, family size, education, land holding, animal status (types of animals, strength, production), feeding system (feeds and fodder availability, sources of feed, feeding methods), health status (types of diseases, symptoms and vaccination mode), breeding methods, assistance needs (subsidy, loan, animals, training) and satisfaction with animal and production aspects through pretested survey instrument specially developed for the purpose. It was found that family size varied from 5.31 (West Bengal) to 9.48 (Eastern UP) and most head of families were educated having more than 0.5ha agriculture land. Majority (70.86%) of the farmers were not able to spare agriculture land for fodder production. A large number of farmers in Assam, Chhattisgarh and Jharkhand had non-descript (ND) cows. However, majority of farmers surveyed in Bihar and eastern UP had crossbred (CB) cow. Average milk production (kg/d), lactation length (m) and dry period (m) amongst animals of eastern region for ND cows 2.48, 7.71, and 6.66, for CB cows 7.20, 9.08, and 3.85 and for buffaloes 5.54, 8.56, and 6.93, respectively. The farmers followed their own feeding practices and offered self-produced feeds. Majority of the farmers of the region reported Foot & Mouth Disease (FMD) as a major concern and were not satisfied with their animals and production. On the basis of this study it can be concluded that livestock farmers of eastern region of India are in great need of improved breeds, they also require capacity building and training on balance feeding and general management practices for better and sustainable animal production

A Diagnostic Study on Livestock Production System in Eastern Region of India

A study was conducted in seven East Indian states, viz. Bihar, West Bengal, Odisha, Chhattisgarh, Jharkhand, Assam and eastern UP, to understand the livestock production and management systems for making strategies for the improving livestock production scenario in the region. The data were collected from two districts from each state and from each district twenty-five (25) farmers were selected. Information was collected farmer‘s socio-economic status like, family size, education, land holding, animal status (types of animals, strength, production), feeding system (feeds and fodder availability, sources of feed, feeding methods), health status (types of diseases, symptoms and vaccination mode), breeding methods, assistance needs (subsidy, loan, animals, training) and satisfaction with animal and production aspects through pretested survey instrument specially developed for the purpose. It was found that family size varied from 5.31 (West Bengal) to 9.48 (Eastern UP) and most head of families were educated having more than 0.5ha agriculture land. Majority (70.86%) of the farmers were not able to spare agriculture land for fodder production. A large number of farmers in Assam, Chhattisgarh and Jharkhand had non-descript (ND) cows. However, majority of farmers surveyed in Bihar and eastern UP had crossbred (CB) cow. Average milk production (kg/d), lactation length (m) and dry period (m) amongst animals of eastern region for ND cows 2.48, 7.71, and 6.66, for CB cows 7.20, 9.08, and 3.85 and for buffaloes 5.54, 8.56, and 6.93, respectively. The farmers followed their own feeding practices and offered self-produced feeds. Majority of the farmers of the region reported Foot & Mouth Disease (FMD) as a major concern and were not satisfied with their animals and production. On the basis of this study it can be concluded that livestock farmers of eastern region of India are in great need of improved breeds, they also require capacity building and training on balance feeding and general management practices for better and sustainable animal production

Atom capture by nanotube and scaling anomaly

The existence of bound state of the polarizable neutral atom in the inverse square potential created by the electric field of single walled charged carbon nanotube (SWNT) is shown to be theoretically possible. The consideration of inequivalent boundary conditions due to self-adjoint extensions lead to this nontrivial bound state solution. It is also shown that the scaling anomaly is responsible for the existence of bound state. Binding of the polarizable atoms in the coupling constant interval \eta^2\in[0,1) may be responsible for the smearing of the edge of steps in quantized conductance, which has not been considered so far in literature.Comment: Accepted in Int.J.Theor.Phy

Parallel tempering in full QCD with Wilson fermions

We study the performance of QCD simulations with dynamical Wilson fermions by combining the Hybrid Monte Carlo algorithm with parallel tempering on $10^4$ and $12^4$ lattices. In order to compare tempered with standard simulations, covariance matrices between sub-ensembles have to be formulated and evaluated using the general properties of autocorrelations of the parallel tempering algorithm. We find that rendering the hopping parameter $\kappa$ dynamical does not lead to an essential improvement. We point out possible reasons for this observation and discuss more suitable ways of applying parallel tempering to QCD.Comment: 16 pages, 3 figure

A Comparison of Solar Cycle Variations in the Equatorial Rotation Rates of the Sun's Subsurface, Surface, Corona, and Sunspot Groups

Using the Solar Optical Observing Network (SOON) sunspot-group data for the period 1985-2010, the variations in the annual mean equatorial-rotation rates of the sunspot groups are determined and compared with the known variations in the solar equatorial-rotation rates determined from the following data: i) the plasma rotation rates at 0.94Rsun, 0.95Rsun,...,1.0Rsun measured by Global Oscillation Network Group (GONG) during the period 1995-2010, ii) the data on the soft X-ray corona determined from Yohkoh/SXT full disk images for the years 1992-2001, iii) the data on small bright coronal structures (SBCS) which were traced in Solar and Heliospheric Observatory (SOHO)/EIT images during the period 1998-2006, and iv) the Mount Wilson Doppler-velocity measurements during the period 1986-2007. A large portion (up to approximate 30 deg latitude) of the mean differential-rotation profile of the sunspot groups lies between those of the internal differential-rotation rates at 0.94Rsun and 0.98Rsun.The variation in the yearly mean equatorial-rotation rate of the sunspot groups seems to be lagging that of the equatorial-rotation rate determined from the GONG measurements by one to two years.The amplitude of the latter is very small.The solar-cycle variation in the equatorial-rotation rate of the solar corona closely matches that determined from the sunspot-group data.The variation in the equatorial-rotation rate determined from the Mount Wilson Doppler-velocity data closely resembles the corresponding variation in the equatorial-rotation rate determined from the sunspot-group data that included the values of the abnormal angular motions (> 3 deg per day) of the sunspot groups. Implications of these results are pointed out.Comment: 22 pages, 10 figures, accepted by Solar Physic