111 research outputs found
QSAR and Molecular Docking Studies on a Series of Cinnamic Acid Analogues as Epidermal Growth Factor Receptor (EGFR) Inhibitors
Quantitative structure-activity relationship (QSAR) and docking studies have been
performed on a large series of cinnamic acid analogues studied by various authors as Epidermal
Growth Factor Receptor (EGFR) inhibitors. A multiple linear regression (MLR) analysis has
shown that electronic properties of these compounds are the governing factors of their activity
and docking study has shown that compounds can form hydrogen bonds with the receptor and
have effective steric interactions involving dispersion forces. Using the MLR model, some new
compounds were proposed that have higher potency than the existing ones.Declared non
3D Deep Learning on Medical Images: A Review
The rapid advancements in machine learning, graphics processing technologies
and availability of medical imaging data has led to a rapid increase in use of
deep learning models in the medical domain. This was exacerbated by the rapid
advancements in convolutional neural network (CNN) based architectures, which
were adopted by the medical imaging community to assist clinicians in disease
diagnosis. Since the grand success of AlexNet in 2012, CNNs have been
increasingly used in medical image analysis to improve the efficiency of human
clinicians. In recent years, three-dimensional (3D) CNNs have been employed for
analysis of medical images. In this paper, we trace the history of how the 3D
CNN was developed from its machine learning roots, give a brief mathematical
description of 3D CNN and the preprocessing steps required for medical images
before feeding them to 3D CNNs. We review the significant research in the field
of 3D medical imaging analysis using 3D CNNs (and its variants) in different
medical areas such as classification, segmentation, detection, and
localization. We conclude by discussing the challenges associated with the use
of 3D CNNs in the medical imaging domain (and the use of deep learning models,
in general) and possible future trends in the field.Comment: 13 pages, 4 figures, 2 table
Superconductivity in Ru substituted BaFe2-xRuxAs2
The occurrence of bulk superconductivity at ~22 K is reported in
polycrystalline samples of BaFe2-xRuxAs2 for nominal Ru content in the range of
x=0.75 to 1.125. A systematic suppression of the spin density wave transition
temperature (TSDW) precedes the appearance of superconductivity in the system.
A phase diagram is proposed based on the measured TSDW and superconducting
transition temperature (TC) variations as a function of Ru composition. Band
structure calculations, indicate introduction of electron carriers in the
system upon Ru substitutiom. The calculated magnetic moment on Fe shows a
minimum at x=1.0, suggesting that the suppression of the magnetic moment is
associated with the emergence of superconductivity. Results of low temperature
and high field Mossbauer measurements are presented. These indicate weakening
of magnetic interaction with Ru substitutionComment: 20 pages 10 figure
Persistence in a Stationary Time-series
We study the persistence in a class of continuous stochastic processes that
are stationary only under integer shifts of time. We show that under certain
conditions, the persistence of such a continuous process reduces to the
persistence of a corresponding discrete sequence obtained from the measurement
of the process only at integer times. We then construct a specific sequence for
which the persistence can be computed even though the sequence is
non-Markovian. We show that this may be considered as a limiting case of
persistence in the diffusion process on a hierarchical lattice.Comment: 8 pages revte
Superconductivity in SmFe1-xMxAsO (M = Co, Rh, Ir)
In this paper we report the comparative study of superconductivity by 3d
(Co), 4d (Rh), 5d (Ir) element doping in SmFeAsO. X-ray diffraction patterns
indicate that the material has formed the ZrCuSiAs-type structure with a space
group P4/nmm. It is found that the antiferromagnetic spin-density-wave (SDW)
order in the parent compounds is rapidly suppressed by Co, Rh, and Ir doping,
and superconductivity emerges. Both electrical resistance and magnetization
measurements show superconductivity up to around 10 K in SmFe1-xMxAsO (M = Co,
Rh, Ir). Co, Rh and Ir locate in the same column in the periodic table of
elements but have different electronic band structure, so comparative study
would add more ingredients to the underlying physics of the iron-based
superconductors.Comment: 16 pages, 4 figures, 1 tabl
- …