Multisector Dynamics: Advancing the Science of Complex Adaptive Human-Earth Systems

The field of MultiSector Dynamics (MSD) explores the dynamics and co-evolutionary pathways of human and Earth systems with a focus on critical goods, services, and amenities delivered to people through interdependent sectors. This commentary lays out core definitions and concepts, identifies MSD science questions in the context of the current state of knowledge, and describes ongoing activities to expand capacities for open science, leverage revolutions in data and computing, and grow and diversify the MSD workforce. Central to our vision is the ambition of advancing the next generation of complex adaptive human-Earth systems science to better address interconnected risks, increase resilience, and improve sustainability. This will require convergent research and the integration of ideas and methods from multiple disciplines. Understanding the tradeoffs, synergies, and complexities that exist in coupled human-Earth systems is particularly important in the context of energy transitions and increased future shocks

Identification of a potent herbal molecule for the treatment of breast cancer

<p>Abstract</p> <p>Background</p> <p>Breast cancer (BCa)-related mortality still remains the second leading cause of cancer-related deaths worldwide. Patients with BCa have increasingly shown resistance and high toxicity to current chemotherapeutic drugs for which identification of novel targeted therapies are required.</p> <p>Methods</p> <p>To determine the effect of PDBD on BCa cells, estrogen-receptor positive (ER⁺)-MCF-7 and estrogen-receptor negative (ER^-)-MDA 231 cells were treated with PDBD and the cell viability, apoptotic, cell cycle, Western blot and Promoter assays were performed.</p> <p>Results</p> <p>PDBD inhibits cell viability of ER⁺and ER^-BCa cells by inducing apoptosis without causing significant toxicity in normal breast epithelial cells. While dissecting the mechanism of action of PDBD on BCa, we found that PDBD inhibits Akt signaling and its downstream targets such as NF-κB activation, IAP proteins and Bcl-2 expression. On the other hand, activation of JNK/p38 MAPK-mediated pro-apoptotic signaling was observed in both ER⁺and ER^-BCa cells.</p> <p>Conclusion</p> <p>These findings suggest that PDBD may have wide therapeutic application in the treatment of BCa.</p

Understanding the Contributions of Paleo‐Informed Natural Variability and Climate Changes to Hydroclimate Extremes in the San Joaquin Valley of California

Abstract To aid California's water sector to better understand and manage future climate extremes, we present a method for creating a regionally consistent ensemble of plausible daily future climate and streamflow scenarios that represent natural climate variability captured in a network of tree‐ring chronologies, and then embed anthropogenic climate change trends within those scenarios. We use 600 years of paleo‐reconstructed weather regimes to force a stochastic weather generator, which we develop for five subbasins in the San Joaquin Valley of California. To assess the compound effects of climate change, we create temperature series that reflect projected scenarios of warming and precipitation series that have been scaled to reflect thermodynamically driven shifts in the distribution of daily precipitation. We then use these weather scenarios to force hydrologic models for each of the five subbasins. The paleo‐forced streamflow scenarios highlight periods in the region's past that produce flood and drought extremes that surpass those in the modern record and exhibit large non‐stationarity through the reconstruction. Variance decomposition is employed to characterize the contribution of natural variability and climate change to variability in decision‐relevant metrics related to floods and drought. Our results show that a large portion of variability in individual subbasin and spatially compounding extreme events can be attributed to natural variability, but that anthropogenic climate changes become more influential at longer planning horizons. The joint importance of climate change and natural variability in shaping extreme floods and droughts is critical to resilient water systems planning and management in the San Joaquin

A 54-year-old male with rapidly progressive neurologic syndrome: Clinicopathologic correlation of a rare diagnosis

Diagnosis of systemic lupus erythematosus (SLE) as primary presentation with central nervous system involvement as a rapidly progressive neurologic syndrome is extremely rare. We present a rare case of a 54-year-old hypertensive male patient, who presented with a fulminant neurologic syndrome. He presented with cerebellar and meningeal signs, aseptic meningitis and had a rapid downhill course following admission. A postmortem revealed feature of systemic connective tissue fulfilling diagnostic criteria of SLE with lupus cerebritis

Influence of Social Media on Youth: A Study of Private University

Internet makes a large offering on online that connect a hard and Fast of section that interacts and change knowledge. Some considerably used social systems collectively with Face book, Twitter, Whatsapp,&nbsp; and Instagram. It has come to be part of all people's life. Social media is a totally vast time period and virtually encompasses numerous different sorts of media, consisting of videos, blogs, etc. It is an area wherein you may transmit statistics approximately different human beings. Social networking is a automobile. It allows all people proportion content material that different human beings can proportion, in turn, with their on-line connections. It offers youths with more than a few blessings and probability to authorize them in numerous methods. Youths can retain civil relationship and may get admission to more statistics than ever before. It has come to be an area where in we spend many hours of the motive of enterprise or entertainment or interact with others or different ambition. The gift have a look at tries to discover the effect of youth with inside the utilization of social media particularly university college students.&nbsp

Large Ensemble Diagnostic Evaluation of Hydrologic Parameter Uncertainty in the Community Land Model Version 5 (CLM5)

Abstract Land surface models such as the Community Land Model version 5 (CLM5) seek to enhance understanding of terrestrial hydrology and aid in the evaluation of anthropogenic and climate change impacts. However, the effects of parametric uncertainty on CLM5 hydrologic predictions across regions, timescales, and flow regimes have yet to be explored in detail. The common use of the default hydrologic model parameters in CLM5 risks generating streamflow predictions that may lead to incorrect inferences for important dynamics and/or extremes. In this study, we benchmark CLM5 streamflow predictions relative to the commonly employed default hydrologic parameters for 464 headwater basins over the conterminous United States (CONUS). We evaluate baseline CLM5 default parameter performance relative to a large (1,307) Latin Hypercube Sampling‐based diagnostic comparison of streamflow prediction skill using over 20 error measures. We provide a global sensitivity analysis that clarifies the significant spatial variations in parametric controls for CLM5 streamflow predictions across regions, temporal scales, and error metrics of interest. The baseline CLM5 shows relatively moderate to poor streamflow prediction skill in several CONUS regions, especially the arid Southwest and Central U.S. Hydrologic parameter uncertainty strongly affects CLM5 streamflow predictions, but its impacts vary in complex ways across U.S. regions, timescales, and flow regimes. Overall, CLM5's surface runoff and soil water parameters have the largest effects on simulated high flows, while canopy water and evaporation parameters have the most significant effects on the water balance