Dust properties from GALEX observations of a UV halo around Spica

GALEX has detected ultraviolet halos extending as far as 5$^{\circ}$ around four bright stars (Murthy et al. (2011)). These halos are produced by scattering of starlight by dust grains in thin foreground clouds that are not physically associated with the star. Assuming a simple model consisting of a single layer of dust in front of the star, Murthy et al.(2011) have been able to model these halo intensities and constrain the value of the phase function asymmetry factor $g$ of the scattering grains in the FUV and NUV. However due to the uncertainty in the dust geometry they could not constrain the albedo. In this work we have tried to constrain the optical constants and dust geometry by modeling the UV halo of Spica. Since the halo emission is not symmetric, we have modeled the Northern and Southern parts of the halo separately. To the North of Spica, the best-fit albedo is 0.26$\pm$0.1 and $g$ is 0.58$\pm$0.11 in the FUV at the 90% confidence level. The corresponding limits on the distance and optical depth ($\tau$) of the dust sheet is 3.65$\pm$1.05 pc and 0.047$\pm$0.006 respectively. However, owing to a complicated dust distribution to the South of Spica, we were unable to uniquely constrain the dust parameters in that region. Nevertheless, by assuming the optical constants of the Northern region and assuming a denser medium, we were able to constrain the distance of the dust to 9.5$\pm$1.5 pc and the corresponding $\tau$ to 0.04$\pm$0.01.Comment: 4 pages, accepted for publication in Earth, Planets and Spac

CHILD LABOUR AND TRADE LIBERALIZATION IN A DEVELOPING ECONOMY

The paper analyzes the implications of trade liberalization on the incidence of child labour in a two-sector general equilibrium framework. The supply function of child labour has been derived from the utility maximizing behaviour of the working families. The paper finds that the effect of trade liberalization on the incidence of child labour crucially hinges on the relative factor intensities of the two sectors.Child labour, general equilibrium, trade liberalization

Human Capital Accumulation and Endogenous Growth in a Dual Economy

Human Capital, Dualism, Economic growth, Rural, Urban, Competitive Equilibrium, Steady-state growth, Planned Economy

International factor mobility, informal interest rate and capital market imperfection: a general equilibrium analysis

This paper makes a pioneering attempt to provide a theory of determination of interest rate in the informal credit market in a small open economy in terms of a three-sector general equilibrium model. There are two informal sectors which obtain production loans from a monopolistic moneylender and employ labour from the informal labour market. On the other hand, the formal sector employs labour at an institutionally fixed wage rate and takes loans from the competitive formal credit market. We show that an inflow of foreign capital and/or an emigration of labour raises (lowers) the informal (formal) interest rate while lowers the competitive wage rate in the informal labour market when the informal manufacturing sector is more capital-intensive vis-à-vis the agricultural informal sector. International factor mobility, therefore, increases the degrees of distortions in both the factor markets in this case.Informal credit, formal credit, moneylender, foreign capital, emigration, general equilibrium

Paclitaxel delivery by micro/nano encapsulation using layer-by-layer assembly

A novel formulation of paclitaxel (PTX) has been developed by providing multilayer assembly over drug loaded porous CaCO3 microparticles (CaCO3 MP) using combination of biocompatible and biodegradable polyelectrolytes (PE’s). PTX was encapsulated into the nanopores of preformed CaCO3 MP prepared by the co-precipitation method. Infrared (IR) and X-ray diffraction (XRD) provides evidences that PTX has been encapsulated into nanopores of CaCO3 MP and not crystallized on the surface. PTX loaded CaCO3 MP (CaCO3-PTX) was found to be highly stabilized against thermal decomposition as evinced by thermo gravimetric analysis (TGA) indicating decomposition at 600°C and 250°C for CaCO3-PTX and PTX respectively. The multilayer assembly over CaCO3-PTX was effectuated by alternate deposition of protamine sulfate (PRM) and sodium alginate (SA) using LBL technique followed by subsequent core removal [PTX- (PRM/SA)5]. The pay load efficiency of PTX in this system was found to be 78.98±2.14%. The developed system was further evaluated for surface morphology, size and size distribution, surface charge, core removal and layer-by-layer growth due to sequential adsorption of PE’s. The release data of PTX-(PRM/SA)5 was comparable with marketed formulation of PTX (PTX-M) and CaCO3-PTX when performed in simulated intestinal fluid (SIF pH=7.4). The release profile of PTX-(PRM/SA)5 indicates that PEs based multilayer matrix is capable to provide barrier to PTX release as it has been found to follow first order matrix diffusion kinetics with 64±4.8% release within 24 hrs. The t50% of PTX-M, CaCO3-PTX and PTX-(PRM/SA)5 was found to be 70, 90 and 480 minutes respectively. This alternative delivery system of PTX disguised in the form of LBL assembly could have immense application for the treatment of metastasized mammary glands vis-à-vis existing formulation of PTX which is by and large criticized for having certain toxic excipients to be given parentrally. Moreover, the proposed system provides ample of opportunity to modify the surface for targeted application of PTX.
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