4-(Pyridin-2-yl)-1,3-dithiol-2-one

In the title compound, C8H5NOS2, the non-H atoms are approximately coplanar [maxium deviation = 0.060 (3) Å]. The dihedral angle between the least-squares planes of the pyridine and 1,3-dithiol-2-one rings is 5.96 (17)°. The crystal packing is stabilized by weak inter­molecular C—H⋯O hydrogen bonds and by an S⋯S close contact [3.510 (5) Å]

Modification of hydrophobic polypeptide-based film by blending with hydrophilic poly(acrylic acid)

In this study, a series of poly(γ-benzyl L-glutamate)/poly(acrylic acid) (PBLG/PAA) polymer blend films were prepared by casting the polymer blend solution in dimethylsulfoxide (DMSO). The structure and morphology of the polymer blend film were investigated by Fourier Transform Infrared Spectroscopy (FT-IR) and Scanning Electron Microscopy (SEM). Thermal, mechanical, and chemical properties of PBLG/PAA polymer blend films were studied by Differential Scanning Calorimetry (DSC), Thermogravimetric (TG) Analysis, Tensile Tests, and measurements of Surface Contact Angles. The results revealed that the introduction of PAA could exert great effects on the structure and properties of the polypeptide films

Physicochemical properties of poly(lactic acid-co-glycolic acid) film modified via blending with poly(butyl acrylate-co-methyl methacrylate)

A series of poly(lactic acid-co-glycolic acid) (PLGA)/poly(butyl acrylate-co-methyl methacrylate) (P(BA-co-MMA)) blend films with different P(BA-co-MMA) mole contents were prepared by casting the polymer blend solution in chloroform. Surface morphologies of the PLGAP(BA-co-MMA) blend films were studied by scanning electron microscopy (SEM). Thermal, mechanical, and chemical properties of PLGAP(BA-co-MMA) blend films were investigated by differential scanning calorimeter (DSC), thermogravimetric analysis (TGA), tensile tests, and surface contact angle tests. The introduction of P(BA-co-MMA) could modify the properties of PLGA films

Genome-wide Identification and Expression Analysis of NRAMP Transporter Genes in Cucumis sativus and Citrullus lanatus

Natural resistance-associated macrophage proteins (NRAMPs) are able to transport various metal ions across cell membranes, which play an important role in plant normal growth and development. Here, a survey of cucumber (Cucumis sativus) and watermelon (Citrullus lanatus) genomes found a total of five CsNRAMPs and four ClNRAMPs, respectively. Based on the phylogenetic relationships, CsNRAMPs and ClNRAMPs were clustered into three groups (I, II and III). Five orthologous pairs were identified between cucumber and watermelon genome, and they were clustered on the same branch of the phylogenetic tree. The number of introns in CsNRAMPs and ClNRAMPs ranged from 3 to 13 and the genes from group Ι were more fragmented than those in group II. Subsequently, analysis of promoter sequences found that five putative transcription factors could act on NRAMPs. Moreover, CsNRAMPs and ClNRAMPs were differentially regulated by deficiencies of Fe, Mn, Cu or Zn, along with toxicities of Fe, Mn, Cu, Zn or Cd. Functional analysis by heterologous expression in yeast indicated that CsNRAMP4 and ClNRAMP3 participate in Cd transport. Overall, the comprehensive analysis of CsNRAMPs and ClNRAMPs reported herein may pave the way for further investigations examining the regulation and functions of this gene family in cucumber and watermelon.The accepted manuscript in pdf format is listed with the files at the bottom of this page. The presentation of the authors' names and (or) special characters in the title of the manuscript may differ slightly between what is listed on this page and what is listed in the pdf file of the accepted manuscript; that in the pdf file of the accepted manuscript is what was submitted by the author

Study on properties of poly(vinyl alcohol)/polyacrylonitrile blend film

In this work, a series of poly(vinyl alcohol) (PVA)/polyacrylonitrile (PAN) blend films with different PAN mole contents were prepared by casting the polymer blend solution in dimethylsulfoxide (DMSO). Surface morphologies of PVA/PAN blend films were analyzed by Scanning Electronic Microscopy (SEM) and Atomic Force Microscopy (AFM). Thermal, mechanical, and chemical properties of PVA/PAN blend films were investigated by Differential Scanning Calorimetry (DSC), Thermogravimetric Analysis (TGA), Tensile Tests, and Surface Contact Angle Tests. The results showed that the introduction of PAN could exert marked effects on the properties of PVA films

Highly Thermal Conductive and Electrically Insulating Epoxy Composites Based on Zinc-Oxide-Coated Silver Nanowires

Nano-ZnO particles were deposited on the surface of silver nanowires (AgNWs) by the precipitation method, and the obtained AgNW@ZnO filler with core-shell structure was added to epoxy resin to prepare AgNW@ZnO/EP thermally conductive composites. The ZnO coating on the surface of AgNWs effectively improves the thermal conductivity of the composites. When 8 wt% AgNW@ZnO filler was added to the epoxy resin, the thermal conductivity of the AgNW@ZnO/EP composite increased to 0.77 W/(m·K). The enhancement of the thermal conductivity is attributed to the fact that ZnO effectively improves the interface bonding between AgNWs and the epoxy matrix, thus strengthening the contact between AgNWs. In addition, the electrical insulation of the AgNW@ZnO/EP composites was improved upon the introduction of the ZnO coating over AgNWs. For the filler content of 8 wt%, the volume resistivity of the AgNW@ZnO/EP composites was found to be higher than 1013 Ω·cm. AgNW@ZnO/EP composites have also exhibited low dielectric constant and good thermal stability

Bioinformatics prediction and experimental verification identify cuproptosis-related lncRNA as prognosis biomarkers of hepatocellular carcinoma

Cuproptosis is a form of cell death caused by intracellular copper excess, which plays an important regulatory role in the development and progression of cancers, including hepatocellular carcinoma (HCC), a prevalent malignancy with high morbidity and mortality.This study aimed to create a cuproptosis associated long non-coding RNAs (CAlncRNAs)signature to predict HCC patient survival and immunotherapy response. Firstly, we identified 509 CAlncRNAs using Pearson correlation analysis in The Cancer Genome Atlas (TCGA) datasets, before the three CAlncRNAs (MKLN1-AS, FOXD2-AS1, LINC02870) with the most prognostic value were further screened. Then, we constructed a prognostic risk model for HCCwas using univariate and LASSO Cox regression analyses. Multivariate Cox regression analyses illustrated that this model was an independent prognostic factor for overall survival (OS) prediction, outperforming traditional clinicopathological factors. And the risk score not only could be prognostic factors independent of other factors but also suited for patients with diverse ages, stages, and grades. The 1-, 3-, and 5- years areas under the curves (AUC) values of the model were 0.759, 0.668 and 0.674 respectively. Pathway analyses showed that the high-risk groupenriched in immune-related pathways. Importantly, patients with higher risk scores exhibited higher mutation frequency, higher TMB scores, and lower TIDE scores. Besides, we screened for two chemical drugs (A-443654 and Pyrimethamine) with the greatest value for high-risk HCC patients. Finally, the abnormal high expression of the three CAlncRNAs were confirmed in HCC tissues and cells by Real Time Quantitative PCR (RT-qPCR). And proliferative, migratory and invasion abilities of HCC cell were restrained via silencing CAlncRNAs expression in vitro.In summary, we built a CAlncRNAs-based risk score model, which can be a candidate for HCC patients prognostic prediction and offer some useful information for immunotherapies