Therapeutic targets and limits of minocycline neuroprotection in experimental ischemic stroke

<p>Abstract</p> <p>Background</p> <p>Minocycline, a second-generation tetracycline with anti-inflammatory and anti-apoptotic properties, has been shown to promote therapeutic benefits in experimental stroke. However, equally compelling evidence demonstrates that the drug exerts variable and even detrimental effects in many neurological disease models. Assessment of the mechanism underlying minocycline neuroprotection should clarify the drug's clinical value in acute stroke setting.</p> <p>Results</p> <p>Here, we demonstrate that minocycline attenuates both <it>in vitro </it>(oxygen glucose deprivation) and <it>in vivo </it>(middle cerebral artery occlusion) experimentally induced ischemic deficits by direct inhibition of apoptotic-like neuronal cell death involving the anti-apoptotic Bcl-2/cytochrome c pathway. Such anti-apoptotic effect of minocycline is seen in neurons, but not apparent in astrocytes. Our data further indicate that the neuroprotection is dose-dependent, in that only low dose minocycline inhibits neuronal cell death cascades at the acute stroke phase, whereas the high dose exacerbates the ischemic injury.</p> <p>Conclusion</p> <p>The present study advises our community to proceed with caution to use the minimally invasive intravenous delivery of low dose minocycline in order to afford neuroprotection that is safe for stroke.</p

Combustion reactivity of ilmenite with coal volatiles under steam gasification atmosphere

学位記番号：理工博甲6

Tracheal suspension with autogenous rib cartilage in a patient with severe tracheomalacia

Abstract Background Tracheomalacia (TM), caused by anterior mediastinal tumorectomy, most likely to deteriorate condition of patient life. Case presentation A 63-year-old patient felt serious dyspnea diagnosis as TM caused by the recurrent cervical schwannoma. The narrowest diameter of the TM was only 0.446 cm and the length of malacic segment was 7.47 cm. Here we designed a novel tracheal suspension technique by using autogenous rib cartilage graft to treat severe TM. The obvious effect was observed that the inner diameter increased from 0.446 cm to 1.390 cm,and the airway symptom was alleviated. Conclusion The autogenous rib cartilage graft used for suspending the malacic trachea was safe and effective