Integrated genetic, physical and transcript map of chromosome 12 (top part)

Note: Three columns are displayed in the figure (left, middle and right). Left column shows the fiber EST unigenes anchored to the chromosome 12; Middle column shows the genetic map, and right column shows the contigs assembled from the positive clones to the genetic markers. The markers in black were used as backbone markers that were derived from an Fmapping population (race "palmeri" and acc. "K101); markers in red (MUSB) were from BAC-end sequence and genetic distance was from the RIL mapping population (TM-1 × 3–79); markers in green (TMB) were from BAC subcloned sequence and mapped by the TM-1 × 3–79 RIL population; the blue markers were from BCmapping population ('Guazuncho 2' × 'VH8-4602'). Markers in pink at the bottom of the figure were from BCmapping population (TM-1 × (TM-1 × Hai7124). CUN stand for Cotton Unigene Number that was used in the original paper [16]. This figure shows the upper part of the whole figure, for the full image please see additional file .<p><b>Copyright information:</b></p><p>Taken from "An integrated genetic and physical map of homoeologous chromosomes 12 and 26 in Upland cotton (L.)"</p><p>http://www.biomedcentral.com/1471-2164/9/108</p><p>BMC Genomics 2008;9():108-108.</p><p>Published online 28 Feb 2008</p><p>PMCID:PMC2270834.</p><p></p

Integrated genetic, physical and transcript map of chromosome 26 (top part)

All legends are same as described for Figure. 1. This figure shows the upper part of the whole figure, for the full image please see additional file .<p><b>Copyright information:</b></p><p>Taken from "An integrated genetic and physical map of homoeologous chromosomes 12 and 26 in Upland cotton (L.)"</p><p>http://www.biomedcentral.com/1471-2164/9/108</p><p>BMC Genomics 2008;9():108-108.</p><p>Published online 28 Feb 2008</p><p>PMCID:PMC2270834.</p><p></p

Effective Theranostic Cyanine for Imaging of Amyloid Species in Vivo and Cognitive Improvements in Mouse Model

We report herein an investigation of carbazole-based cyanine, (<i>E</i>)-4-(2-(9-(2-(2-methoxyethoxy)­ethyl)-9<i>H</i>-carbazol-3-yl)-vinyl)-1-methyl-quinolin-1-iumiodide (SLM), as an effective theranostic agent for Alzheimer’s disease (AD). This cyanine exhibited desirable multifunctional and biological properties, including amyloid-β (Aβ)-oligomerization inhibition, blood–brain barrier permeability, low neurotoxicity, neuroprotective effect against Aβ-induced toxicities, high selectivity and strong binding interactions with Aβ peptide/species, good biostability, as well as strong fluorescence enhancement upon binding to Aβ species for diagnosis and therapy of AD. This cyanine has been successfully applied to perform near-infrared in vivo imaging of Aβ species in transgenic AD mouse model. The triple transgenic AD mice intraperitoneally treated with SLM showed significant recovery of cognitive deficits. Furthermore, those SLM-treated mice exhibited a substantial decrease in both of oligomeric Aβ contents and tau proteins in their brain, which was attributed to the induction of autophagic flux. These findings demonstrated for the first time that SLM is an effective theranostic agent with in vivo efficacy for diagnosis and treatment of AD in mouse models