Safety estimation for a new model of regenerative and frictional cutting dynamics

Acknowledgements This research is supported by National Natural Science Foundation of China (Grants No. 11872147, 12072068, 11932015 and 11502048).Peer reviewedPostprin

On the non-equivalence of Lorenz System and Chen System

In this paper, we prove that the Chen system with a set of chaotic parameters is not smoothly equivalent to the Lorenz system with any parameters

Hazard identification of dehydroacetic acid and its sodium salt used as food additives based on systematic literature searches

The current study, using a systematic-literature-search approach, was intended to conduct hazard identification for dehydroacetic acid (DHA) and sodium dehydroacetate (DHA-S) which are currently used as food additives in China. DHA and DHA-S belong to the category of low toxic chemicals in terms of acute toxicity, mainly causing adverse effects in the central nervous system. Its subacute, subchronic and chronic toxicity mainly include significant reduction of body weight and food intake as well as anticoagulant effect. Reproductive development toxicity result show they can decrease body weight and inhibit bone development in offspring. According to the hazard identification result, oral intake of dehydroacetic acid and its sodium salt can produce a variety of toxic effects above certain doses. Further study is needed to determine the acceptable daily intake of DHA and its sodium salt and provide scientific evidence for safely use of these compounds as food additives

Daily Exposure to a Cranberry Polyphenol Oral Rinse Alters the Oral Microbiome but Not Taste Perception in PROP Taster Status Classified Individuals

Diet and salivary proteins influence the composition of the oral microbiome, and recent data suggest that TAS2R38 bitter taste genetics may also play a role. We investigated the effects of daily exposure to a cranberry polyphenol oral rinse on taste perception, salivary proteins, and oral microbiota. 6-n-Propylthiouracil (PROP) super-tasters (ST, n = 10) and non-tasters (NT, n = 10) rinsed with 30 mL of 0.75 g/L cranberry polyphenol extract (CPE) in spring water, twice daily for 11 days while consuming their habitual diets. The 16S rRNA gene sequencing showed that the NT oral microbiome composition was different than that of STs at baseline (p = 0.012) but not after the intervention (p = 0.525). Principal coordinates analysis using unweighted UniFrac distance showed that CPE modified microbiome composition in NTs (p = 0.023) but not in STs (p = 0.096). The intervention also altered specific salivary protein levels (α-amylase, MUC-5B, and selected S-type Cystatins) with no changes in sensory perception. Correlation networks between oral microbiota, salivary proteins, and sensory ratings showed that the ST microbiome had a more complex relationship with salivary proteins, particularly proline-rich proteins, than that in NTs. These findings show that CPE modulated the oral microbiome of NTs to be similar to that of STs, which could have implications for oral health

Diagnostic efficacy of metagenomic next generation sequencing in bronchoalveolar lavage fluid for proven invasive pulmonary aspergillosis

ObjectiveTo assess the diagnostic efficacy of metagenomic next generation sequencing (mNGS) for proven invasive pulmonary aspergillosis (IPA).MethodsA total of 190 patients including 53 patients who had been diagnosed with proven IPA were retrospectively analyzed. Using the pathological results of tissue biopsy specimens as gold standard, we ploted the receiver operating characteristic (ROC) curve to determine the optimal cut-off value of mNGS species-specific read number (SSRN) of Aspergillus in bronchoalveolar lavage fluid (BALF)for IPA. Furthermore, we evaluated optimal cut-off value of mNGS SSRN in different populations.ResultsThe optimal cut-off value of Aspergillus mNGS SSRN in BALF for IPA diagnosis was 2.5 for the whole suspected IPA population, and 1 and 4.5 for immunocompromised and diabetic patients, respectively. The accuracy of mNGS was 80.5%, 73.7% and 85.3% for the whole population, immunocompromised and diabetic patients, respectively.ConclusionsThe mNGS in BALF has a high diagnostic efficacy for proven IPA, superioring to Aspergillus culture in sputum and BALF and GM test in blood and BALF. However, the cut-off value of SSRN should be adjusted when in different population