Improvement of the hillslope-storage Boussinesq model by considering lateral flow in the unsaturated zone

Abstract Unsaturated flow is an important factor that affects groundwater motion. Among various drainage models, the nonlinear Hillslope-storage Boussinesq (HSB) model has been commonly used to predict water flux along a slope. In this study, we improved this model by considering lateral flow in the unsaturated zone. Using modified van Genuchten functions, we analytically expressed the concept of equivalent propagation thickness in the vadose zone. This analytical expression was then incorporated into the HSB model to reflect two different stages of the drainage process and to simulate the hillslope drainage process more accurately. The model results indicated that lateral flow has significant effects in the unsaturated zone during the hillslope drainage process. Even in sandy aquifers, the amount of water contributed by the unsaturated zone is a key factor that enables a decrease in the water table during the middle and late stages of the process. A comparison between the measured and simulated results based on both convergent-type and divergent-type hillslope drainage processes revealed that the thickness of the saturated zone decreases as the unsaturated flow increases. This study emphasizes the necessity of considering unsaturated flow in the HSB model to improve the accuracy of predicting groundwater outflow rates and develop more accurate hydrographs. The concept of equivalent propagation thickness also provides a criterion for assessing the importance of unsaturated lateral flow for future drainage research

Mitochondrial ferritin attenuates cerebral ischaemia/reperfusion injury by inhibiting ferroptosis

Ischaemic stroke is becoming the most common cerebral disease in aging populations, but the underlying molecular mechanism of the disease has not yet been fully elucidated. Increasing evidence has indicated that an excess of iron contributes to brain damage in cerebral ischaemia/reperfusion (I/R) injury. Although mitochondrial ferritin (FtMt) plays a critical role in iron homeostasis, the molecular function of FtMt in I/R remains unknown. We herein report that FtMt levels are upregulated in the ischaemic brains of mice. Mice lacking FtMt experience more severe brain damage and neurological deficits, accompanied by typical molecular features of ferroptosis, including increased lipid peroxidation and disturbed glutathione (GSH) after cerebral I/R. Conversely, FtMt overexpression reverses these changes. Further investigation shows that Ftmt ablation promotes I/R-induced inflammation and hepcidin-mediated decreases in ferroportin1, thus markedly increasing total and chelatable iron. The elevated iron consequently facilitates ferroptosis in the brain of I/R. In brief, our results provide evidence that FtMt plays a critical role in protecting against cerebral I/R-induced ferroptosis and subsequent brain damage, thus providing a new potential target for the treatment/prevention of ischaemic stroke

Effects of unsaturated flow on Hillslope recession characteristics

Recession flow analysis is usually conducted to infer hydraulic parameters of hillslope aquifers. Various Boussinesq equation-based models, both linear and nonlinear, have been used to analyze the recession curves for sloping aquifers, with a focus on the long-time recession behavior. Based on a modified Boussinesq equation with capillarity incorporated, we demonstrate the significant effect of unsaturated flow on the recession curve, which result in three (instead of two) power law regimes with two transition points (instead of one) corresponding to the formation of a fully unsaturated zone at the adjacent area of the upslope boundary and across the whole domain, respectively. The results show that the power of the second and third recession regime is variable, depending on the slope angles, soil types, and hillslope geometries. The unsaturated flow effects also lead to the absence of drastic drop of (Formula presented.) at the transition between the first and second regime, which was predicted by previous numerical models but has not been observed in the field or laboratory experiments. These findings have important implications for recession flow analysis in studies of hillslope aquifers

Mitochondrial Ferritin Deletion Exacerbates β

Mitochondrial ferritin (FtMt) is a mitochondrial iron storage protein which protects mitochondria from iron-induced oxidative damage. Our previous studies indicate that FtMt attenuates β-amyloid- and 6-hydroxydopamine-induced neurotoxicity in SH-SY5Y cells. To explore the protective effects of FtMt on β-amyloid-induced memory impairment and neuronal apoptosis and the mechanisms involved, 10-month-old wild-type and Ftmt knockout mice were infused intracerebroventricularly (ICV) with Aβ25–35 to establish an Alzheimer’s disease model. Knockout of Ftmt significantly exacerbated Aβ25–35-induced learning and memory impairment. The Bcl-2/Bax ratio in mouse hippocampi was decreased and the levels of cleaved caspase-3 and PARP were increased. The number of neuronal cells undergoing apoptosis in the hippocampus was also increased in Ftmt knockout mice. In addition, the levels of L-ferritin and FPN1 in the hippocampus were raised, and the expression of TfR1 was decreased. Increased MDA levels were also detected in Ftmt knockout mice treated with Aβ25–35. In conclusion, this study demonstrated that the neurological impairment induced by Aβ25–35 was exacerbated in Ftmt knockout mice and that this may relate to increased levels of oxidative stress

Plasma Lipidomics Profiling Reveals Biomarkers for Papillary Thyroid Cancer Diagnosis

The objective of this study was to identify potential biomarkers and possible metabolic pathways of malignant and benign thyroid nodules through lipidomics study. A total of 47 papillary thyroid carcinomas (PTC) and 33 control check (CK) were enrolled. Plasma samples were collected for UPLC-Q-TOF MS system detection, and then OPLS-DA model was used to identify differential metabolites. Based on classical statistical methods and machine learning, potential biomarkers were characterized and related metabolic pathways were identified. According to the metabolic spectrum, 13 metabolites were identified between PTC group and CK group, and a total of five metabolites were obtained after further screening. Its metabolic pathways were involved in glycerophospholipid metabolism, linoleic acid metabolism, alpha-linolenic acid metabolism, glycosylphosphatidylinositol (GPI)—anchor biosynthesis, Phosphatidylinositol signaling system and the metabolism of arachidonic acid metabolism. The metabolomics method based on PROTON nuclear magnetic resonance (NMR) had great potential for distinguishing normal subjects from PTC. GlcCer(d14:1/24:1), PE-NME (18:1/18:1), SM(d16:1/24:1), SM(d18:1/15:0), and SM(d18:1/16:1) can be used as potential serum markers for the diagnosis of PTC

Analysis of metabolites of bactrain camel milk in Alxa of China before and after fermentation with fermenting agent TR1 based on untargeted LC-MS/MS based metabolomics

Camel milk produces many beneficial functional compounds and affects body health through metabolism. The differential metabolites of bactrain camel milk in Alxa before and after fermentation were identified by liquid chromatography-tandem mass spectrometry based metabolomics (LC-MS/MS). The differential metabolite pathway types were also identified in this paper. We obtained the following results that 148 and 82 differential metabolites were detected in positive and negative ion mode respectively, 85 differential metabolites were shown a significant upward trend and 63 with downward trend after fermentation in positive ion mode. Meanwhile, 32 differential metabolites characterized upward trend and 50 characterized downward trend in negative ion mode. The differential metabolites were mainly organic acids, amino acids, esters, vitamins and other substances contained in camel milk. Among them, most up-regulated substances had the functions of lowering blood pressure, lowering blood sugar, treatment of inflammation, antibiosis and other effects. Many harmful substances were significantly down-regulated after camel milk fermentation. However, there were also some metabolites whose prebiotic functions have been weakened by camel milk fermentation, which may provide reference values for healthcare function, exploitation and application of camel milk

A hybrid sampling method for the fuzzy stochastic uncertainty analysis of seawater intrusion simulations

The traditional fuzzy stochastic hybrid method requires hundreds or even thousands of simulations to obtain a statistically stable result, which is a significant challenge for some nonlinear problems, such as simulating seawater intrusion. A hybrid sampling (HS) method was developed based on the Monte Carlo (MC) uncertainty analysis whose input parameters are characterized by both stochastic variables and fuzzy numbers. The HS method is a restricted sampling method that fully captures statistical information on the stochastic variables and the fuzzy memberships provided by fuzzy numbers. In HS, samples of stochastic variables and fuzzy numbers are generated using Latin hypercube sampling and restricted stratified sampling, respectively. After they have been generated, samples of different variables are paired to form inputs in a restricted manner for the simulations. This ensures that the samples are distributed across each variable's range of uncertainty. The correlations between different variables are also controlled during the restricted sampling process. The simulations of seawater intrusions show that the means and variances of the samples generated using the HS method converge more quickly compared with those generated using a random sampling method. The number of MC simulations required was significantly reduced by using the HS method, which improves the effectiveness of predicting seawater intrusion for the management of coastal aquifers

Improvement of the hillslope-storage Boussinesq model by considering lateral flow in the unsaturated zone

Unsaturated flow is an important factor that affects groundwater motion. Among various drainage models, the nonlinear Hillslope-storage Boussinesq (HSB) model has been commonly used to predict water flux along a slope. In this study, we improved this model by considering lateral flow in the unsaturated zone. Using modified van Genuchten functions, we analytically expressed the concept of equivalent propagation thickness in the vadose zone. This analytical expression was then incorporated into the HSB model to reflect two different stages of the drainage process and to simulate the hillslope drainage process more accurately. The model results indicated that lateral flow has significant effects in the unsaturated zone during the hillslope drainage process. Even in sandy aquifers, the amount of water contributed by the unsaturated zone is a key factor that enables a decrease in the water table during the middle and late stages of the process. A comparison between the measured and simulated results based on both convergent-type and divergent-type hillslope drainage processes revealed that the thickness of the saturated zone decreases as the unsaturated flow increases. This study emphasizes the necessity of considering unsaturated flow in the HSB model to improve the accuracy of predicting groundwater outflow rates and develop more accurate hydrographs. The concept of equivalent propagation thickness also provides a criterion for assessing the importance of unsaturated lateral flow for future drainage research

An alternative Boussinesq equation considering the effect of hysteresis on coastal groundwater waves

Abstract This paper presents an alternative Boussinesq equation considering hysteresis effect via a third-order derivative term. By introducing an improved moisture-pressure retention function, this equation describes, with reasonable precision, groundwater propagation in coastal aquifers subject to Dirichlet boundary condition of different oscillation frequencies. Test results confirmed that it is necessary to consider horizontal and vertical flows in unsaturated zone, because of their variable influences on hysteresis. Hysteresis in unsaturated zone can affect the water table wave number of groundwater wave motion, such as wave damping rate and phase lag. Oscillations with different periods exert different hysteresis effect on wave propagation. Truncation/shrinkage of unsaturated zones also affects the strength of hysteresis. These impacts can be reflected in the alternative Boussinesq equation by adjusting the parameter representing the variation rate of moisture associated with pressure change, as opposed to traditional computationally expensive hysteresis algorithms. The present Boussinesq equation is simple to use and can provide feasible basis for future coupling of groundwater and surface water models

Analysis of the morphological changes and related sediment transport mechanisms of the Baisha Shoal in the Qiongzhou Strait, China

Kong, J.; Pan, M.; Shen, C.; Hua, G., and Zhao, H., 2016. Analysis of the morphological changes and related sediment transport mechanisms of the Baisha Shoal in the Qiongzhou Strait, China. The morphological changes and evolutionary mechanism of the Baisha Shoal in the Qiongzhou Strait were investigated using various methods, including bathymetric chart comparisons, geomodeling, hydrodynamic modeling, and hydrologic statistical analysis. Water depths were extracted from digitized charts to explore the evolution of the Baisha Shoal and to quantitatively estimate the changes in the shoal area within the 5-m isobath. The grain-size trend analysis (GSTA) model was introduced to explain the features of bed sediment distribution and to analyze the sources of the sediment. Tidal flow models and wave models were adopted to simulate the tidal flows and wave fields around the Baisha Shoal and to reveal the sediment transport dynamics. Further comparisons based on a Mann-Kendall trend analysis and remote-sensing image data from different years were used to discuss the reason for the recent evolution of the Baisha Shoal. The results show that the formation of the Baisha Shoal was caused by the combined effects of reciprocating flow in the eastern and western directions and waves from the NE direction. However, in recent years, the Baisha Shoal has demonstrated an unsteady geomorphological state and is transitioning from a deposition-dominated state to an erosion-dominated state. Erosion has become most significant since 2004, as reflected in the shoal area within the 5-m isobath, which is decreasing by 0.732 km/y. The analysis demonstrated that a reduction in sediment load and increased sand mining are the two most significant factors that are progressively altering the shoal morphology. If these issues cannot be resolved, the strong dynamic surroundings will aggravate the erosion of the Baisha Shoal. This study on the Baisha Shoal highlights the necessity of combining different approaches to better understand coastal evolutionary features, dynamic mechanisms, and evolutionary causes, as well as to guide future coastal protection engineering design