3-Dimensional Dynamic Quantitative Analysis System of Facial Motion.

<p>3-Dimensional Dynamic Quantitative Analysis System of Facial Motion.</p

Static measurement <i>ICC</i>.

<p>X =  X axis, Z =  Z axis, ∠ = angle.</p><p>Static measurement <i>ICC</i>.</p

Reference planes.

<p>Reference planes.</p

A, online reconstruction; B, offline reconstruction.

<p>A, online reconstruction; B, offline reconstruction.</p

Specialized helmet.

<p>Specialized helmet.</p

Standardized facial expressions.

<p>Standardized facial expressions.</p

Observational points on face.

<p>A/a tragus parallel to the upper wall of external acoustic canal, B/b central position above the eyebrow, C/c center of the upper eyelid, D/d center of the lower eyelid, E/e angulus oculi temporalis, F/f angulus oculi medialis, G/g ala of the nose, H/h corner of the mouth, I root of the columella nasi, J center of eyebrows, K bony–cartilaginous junction along the nasal dorsum, II philtrum, III center of the lower lip.</p

Highly Functional Unsaturated Ester Macromonomer Derived from Soybean Oil: Synthesis and Copolymerization with Styrene

A highly functional unsaturated ester macromonomer was synthesized from soybean oil (SBO), and its chemical structure was confirmed by FT-IR, ¹H NMR, ¹³C NMR, and gel permeation chromatography. The monomer was prepared through modifying epoxidized soybean oil (ESO) first with a synthesized precursor, hydroxyethyl acrylated maleate (HEAMA), and then employing maleic anhydride (MA) to modify the produced ESO-HEAMA. The obtained SBO-based monomer (ESO-HEAMA-MA) possessed a CC bond functionality of 6.75–8.15 per ESO. Effects of styrene concentration, feed ratio, and initiator concentration on the dynamic mechanical properties of the cured bioresins were investigated carefully. When the monomer with the highest CC bond functionality was used, the cured resins with 20–60 wt % styrene demonstrated cross-link densities of 5.07–9.52 (10³ mol)/m³, storage moduli at 25 °C of 1.32–2.16 GPa, glass transition temperatures of 69.9–114.1 °C, and tensile strengths and moduli of 19.7–33.1 MPa and 1.17–2.11 GPa, respectively. Microstructural morphologies of tensile-fractured surfaces of the cured resins were studied by scanning electron microscopy. Finally, curing behaviors of the resultant resin was studied by differential scanning calorimetry. The developed eco-friendly biomaterials have potential applications in the industry of unsaturated polyester resins

High-Performance Poly(lactic-co-glycolic acid)-Magnetic Microspheres Prepared by Rotating Membrane Emulsification for Transcatheter Arterial Embolization and Magnetic Ablation in VX₂ Liver Tumors

Interventional embolization is a popular minimally invasive vascular therapeutic technique and has been widely applied for hepatocellular carcinoma (HCC) therapy. However, harmful effects caused by transcatheter arterial chemoembolization (TACE) and radioembolization, such as the toxicity of chemotherapy or excessive radiation damage, are serious disadvantages and significantly reduce the therapeutic efficacy. Here, a synergistic therapeutic strategy combined transcatheter arterial embolization and magnetic ablation (TAEMA) by using poly­(lactic-<i>co</i>-glycolic acid) (PLGA)-magnetic microspheres (MMs) has been successfully applied to orthotopic VX₂ liver tumors of rabbits. These MMs fabricated by novel rotating membrane emulsification system with well-controlled sizes (100–1000 μm) exhibited extremely low hemolysis ratio and excellent biocompatibility with HepG2 cells and L02 cells. Moreover, experimental results demonstrated that, while exposed to alternating magnetic field (AMF) after TAE, the tumor edge could be heated up by more than 15 °C both in vivo and in vitro, whereas only a negligible increase of temperature was observed in the normal hepatic parenchyma (NHP) nearby. Sufficient temperature increase induces apoptosis of tumor cells. This can further inhibit the tumor angiogenesis and results in necrosis compared to the rabbits only treated with TAE. In stark contrast, tumors rapidly grow and subtotal metastasis occurs in the lungs or kidneys, causing severe complications for rabbits only irradiated under AMF. Importantly, the results from the biochemical examination and the gene expression of relative HCC markers further confirmed that the treatment protocol using PLGA-MMs could achieve good biosafety and excellent therapeutic efficacy, which are promising for liver cancer therapy

Boosted Sensor Performance by Surface Modification of Bifunctional <i>rht</i>-Type Metal–Organic Framework with Nanosized Electrochemically Reduced Graphene Oxide

The surface and interface could be designed to enhance properties of electrocatalysts, and they are regarded as the key characteristics. This report describes surface modification of a bifunctional <i>rht</i>-type metal–organic framework (MOF, Cu-TDPAT) with nanosized electrochemically reduced graphene oxide (n-ERGO). The hybrid strategy results in a Cu-TDPAT–n-ERGO sensor with sensitive and selective response toward hydrogen peroxide (H₂O₂). Compared with Cu-TDPAT, Cu-TDPAT–n-ERGO exhibits significantly enhanced electrocatalytic activities, highlighting the importance of n-ERGO in boosting their electrocatalytic activity. The sensor shows a wide linear detection range (4–12 000 μM), and the detection limit is 0.17 μM (S/N = 3) which is even lower than horseradish peroxidase or recently published noble metal nanomaterial based biosensors. Moreover, the sensor displays decent stability, excellent anti-interference performance, and applicability in human serum and urine samples. Such good sensing performance can be explained by the synergetic effect of bifunctional Cu-TDPAT (open metal sites and Lewis basic sites) and n-ERGO (excellent conductive property). It is expected that <i>rht</i>-type MOF-based composites can provide wider application potential for the construction of bioelectronics devices, biofuel cells, and biosensors