Design methodology for behavioral surface roughness modeling and high-speed test board design

A behavioral model is introduced, which can predict low-loss and low surface roughness transmission line time- and frequency- domain performances. High data rates push for better performance of PCB transmission lines. However, the roughness of copper foil has a considerable impact on the signal integrity performance of transmission lines at high data rates and long propagation distance. Existing models for low-loss transmission line surface roughness are inadequate. A new behavioral model to represent the surface roughness has been developed. The model is applied in the design process by adding a dispersive term to the bulk dielectric permittivity to represent the loss due to the foil surface roughness. By adding a broadband dielectric model into original transmission model, time- and frequency-domain performance improvements is achieved. Two version of high-speed PCB test board via-transition design optimization is presented, the goal is to make the working frequency up to 50GHz and also will summarize a design flow for design a high-speed board with single and differential signal traces --Abstract, page iii

The Mechanism of Crowd Stampede Based on Case Statistics through SNA Method

Stampede is a concern of urban pubic security management. The current academic research focus is the identification of risk factors of trampling accidents and determination of correlation patterns and accident-causing mechanisms among stampede elements in order to effectively obtain the influencing factors of stampede and clarify the transmission routes of stampede risk factors. Previous index cases were scrutinized and analyzed in 78 typical stampedes from 2010 - 2019 based on "pedestrian-equipment-environment-management" framework, and 17 influencing factors of stampede by adopting a conceptual coding method were obscured. Then, the degree centrality, intermediate centrality and respective weights of the influencing factors were calculated based on the social network analysis (SNA) method. The influencing level of the factors was signified, and the transmission mechanism of risk in the system network was determined. The results reveal that the degree centrality and weight with conspicuous features of over-density of crowds, pedestrian swarming and falling, and insufficient on-site transactions contribute the most. This finding indicates that these factors play a relatively major role in the stampede system. Furthermore, the intermediate centrality of insufficient on-site transactions is the top factor, meaning that this factor has a strong controlling force in the incident system and considerably influences other factors. This study shows that the SNA method is feasible in analyzing the mechanism of stampede incidents, simultaneously addressing the shortcomings of the linear statistical model of factors and providing theoretical support for comprehensive control of crowd risk

Sensing and control scheme for the inteferometer configuration with an L-shaped resonator

The detection of high-frequency gravitational waves around kHz is critical to understanding the physics of binary neutron star mergers. A new interferometer design has been proposed in [Phys. Rev. X {\bf 13}, 021019 (2023)], featuring an L-shaped optical resonator as the arm cavity, which resonantly enhances kHz gravitational-wave signals. This new configuration has the potential to achieve better high-frequency sensitivity than the dual-recycled Fabry-Perot Michelson. In this article, we propose a sensing and control scheme for this configuration. Despite having the same number of length degrees of freedom as the dual-recycled Fabry-Perot Michelson, the new configuration requires one less degree of freedom to be controlled due to the degeneracy of two length degrees of freedom at low frequencies. We has also shown that introducing the Schnupp asymmetry is ineffective for controlling the signal-recycling cavity length. Therefore, we propose adding control fields from the dark port to control this auxiliary degree of freedom.Comment: 19 pages,9 figure

A Bayesian Approach to Block Structure Inference in AV1-based Multi-rate Video Encoding

Due to differences in frame structure, existing multi-rate video encoding algorithms cannot be directly adapted to encoders utilizing special reference frames such as AV1 without introducing substantial rate-distortion loss. To tackle this problem, we propose a novel bayesian block structure inference model inspired by a modification to an HEVC-based algorithm. It estimates the posterior probabilistic distributions of block partitioning, and adapts early terminations in the RDO procedure accordingly. Experimental results show that the proposed method provides flexibility for controlling the tradeoff between speed and coding efficiency, and can achieve an average time saving of 36.1% (up to 50.6%) with negligible bitrate cost.Comment: published in IEEE Data Compression Conference, 201

Aberrant Neuromagnetic Activation in the Motor Cortex in Children with Acute Migraine: A Magnetoencephalography Study

Migraine attacks have been shown to interfere with normal function in the brain such as motor or sensory function. However, to date, there has been no clinical neurophysiology study focusing on the motor function in children with migraine during headache attacks. To investigate the motor function in children with migraine, twenty-six children with acute migraine, meeting International Classification of Headache Disorders criteria and age- and gender-matched healthy children were studied using a 275-channel magnetoencephalography system. A finger-tapping paradigm was designed to elicit neuromagnetic activation in the motor cortex. Children with migraine showed significantly prolonged latency of movement-evoked magnetic fields (MEF) during finger movement compared with the controls. The correlation coefficient of MEF latency and age in children with migraine was significantly different from that in healthy controls. The spectral power of high gamma (65–150 Hz) oscillations during finger movement in the primary motor cortex is also significantly higher in children with migraine than in controls. The alteration of responding latency and aberrant high gamma oscillations suggest that the developmental trajectory of motor function in children with migraine is impaired during migraine attacks and/or developmentally delayed. This finding indicates that childhood migraine may affect the development of brain function and result in long-term problems

Aberrant Neuromagnetic Activation in the Motor Cortex in Children with Acute Migraine: A Magnetoencephalography Study

Migraine attacks have been shown to interfere with normal function in the brain such as motor or sensory function. However, to date, there has been no clinical neurophysiology study focusing on the motor function in children with migraine during headache attacks. To investigate the motor function in children with migraine, twenty-six children with acute migraine, meeting International Classification of Headache Disorders criteria and age- and gender-matched healthy children were studied using a 275-channel magnetoencephalography system. A finger-tapping paradigm was designed to elicit neuromagnetic activation in the motor cortex. Children with migraine showed significantly prolonged latency of movement-evoked magnetic fields (MEF) during finger movement compared with the controls. The correlation coefficient of MEF latency and age in children with migraine was significantly different from that in healthy controls. The spectral power of high gamma (65–150 Hz) oscillations during finger movement in the primary motor cortex is also significantly higher in children with migraine than in controls. The alteration of responding latency and aberrant high gamma oscillations suggest that the developmental trajectory of motor function in children with migraine is impaired during migraine attacks and/or developmentally delayed. This finding indicates that childhood migraine may affect the development of brain function and result in long-term problems

Cumulative live birth rates and birth outcomes after IVF/ICSI treatment cycles in young POSEIDON patients: A real-world study

ObjectiveThe aim of this study was to describe the cumulative live birth rates (CLBRs) of young women with or without low prognosis according to the POSEIDON criteria after IVF/ICSI cycles and to investigate whether the diagnosis of low prognosis increases the risk of abnormal birth outcomes.DesignRetrospective study.SettingA single reproductive medicine center.PopulationFrom January 2016 to October 2020, there were 17,893 patients (<35 years) involved. After screening, 4,105 women were included in POSEIDON group 1, 1,375 women were included in POSEIDON group 3, and 11,876 women were defined as non-POSEIDON.Intervention(s)Baseline serum AMH level was measured on the D2–D3 of menstrual cycle before IVF/ICSI treatment.Main outcome measure(s)Cumulative live birth rate (CLBR), birth outcomes.Result(s)After four stimulation cycles, the CLBRs in POSEIDON group 1, POSEIDON group 3, and non-POSEIDON group reached 67.9% (95% CI, 66.5%–69.3%), 51.9% (95% CI, 49.2%–54.5%), and 79.6% (95% CI, 78.9%–80.3%), respectively. There was no difference in gestational age, preterm delivery, cesarean delivery, and low birth weight infants between the three groups, but macrosomia was significantly higher in non-POSEIDON group, after adjusting for maternal age and BMI.Conclusion(s)The POSEIDON group shows lower CLBRs than the non-POSEIDON group in young women, while the risk of abnormal birth outcomes in the POSEIDON group will not increase

Single-Cell Transcriptomics of Proliferative Phase Endometrium: Systems Analysis of Cell–Cell Communication Network Using CellChat

The endometrium thickness increases by which endometrial angiogenesis occurs in parallel with the rapid growth of endometrium during the proliferative phase, which is orchestrated by complex cell–cell interactions and cytokine networks. However, the intercellular communication has not been fully delineated. In the present work, we studied the cell–cell interactome among cells of human proliferative phase endometrium using single-cell transcriptomics. The transcriptomes of 33,240 primary endometrial cells were profiled at single-cell resolution. CellChat was used to infer the cell–cell interactome by assessing the gene expression of receptor–ligand pairs across cell types. In total, nine cell types and 88 functionally related signaling pathways were found. Among them, growth factors and angiogenic factor signaling pathways, including EGF, FGF, IGF, PDGF, TGFb, VEGF, ANGPT, and ANGPTL that are highly associated with endometrial growth, were further analyzed and verified. The results showed that stromal cells and proliferating stromal cells represented cell–cell interaction hubs with a large number of EGF, PDGF incoming signals, and FGF outgoing signals. Endothelial cells exhibited cell–cell interaction hubs with a plenty of VEGF, TGFb incoming signals, and ANGPT outgoing signals. Unciliated epithelial cells, ciliated epithelial cells, and macrophages exhibited cell–cell interaction hubs with substantial EGF outgoing signals. Ciliated epithelial cells represented cell–cell interaction hubs with a large number of IGF and TGFb incoming signals. Smooth muscle cells represented lots of PDGF incoming signals and ANGPT and ANGPTL outgoing signals. This study deconvoluted complex intercellular communications at the single-cell level and predicted meaningful biological discoveries, which deepened the understanding of communications among endometrial cells

Psoriasis comorbid with atherosclerosis meets in lipid metabolism

Psoriasis (PSO) is a common skin disease affecting approximately 1%–3% of the population, and the incidence rate is increasing yearly. PSO is associated with a dramatically increased risk of cardiovascular disease, the most common of which is atherosclerosis (AS). In the past, inflammation was considered to be the triggering factor of the two comorbidities, but in recent years, studies have found that lipid metabolism disorders increase the probability of atherosclerosis in patients with psoriasis. In this review, we discuss epidemiological studies, clinical treatment methods, risk factors, and lipid metabolism of psoriasis and atherosclerosis comorbidities

Potential Fungi Isolated From Anti-biodegradable Chinese Medicine Residue to Degrade Lignocellulose

Traditional Chinese medicine is one of the ancient medicines which is popular in Asian countries, among which the residue produced by the use of anti-biodegradables is endless, and causes significant adverse impacts on the environment. However, the high acidity of anti-biodegradable residues and some special biological activities make it difficult for microorganisms to survive, resulting in a very low degradation rate of lignocellulose in naturally stacked residues, which directly impedes the degradation of residues. We aimed to identify the fungal strains that efficiently biodegrade anti-biodegradable residue and see the possibility to improve the biodegradation of it and other agricultural wastes by co-cultivating these fungi. We isolated 302 fungal strains from anti-biodegradable residue to test hydrolysis ability. Finally, we found Coniochaeta sp., Fomitopsis sp., Nemania sp., Talaromyces sp., Phaeophlebiopsis sp. which inhabit the anti-biodegradable residues are capable of producing higher concentrations of extracellular enzymes. Synergistic fungal combinations (viz., Fomitopsis sp. + Phaeophlebiopsis sp.; Talaromyces sp. + Coniochaeta sp. + Fomitopsis sp.; Talaromyces sp. + Fomitopsis sp. + Piloderma sp. and Talaromyces sp. + Nemania sp. + Piloderma sp.) have better overall degradation effect on lignocellulose. Therefore, these fungi and their combinations have strong potential to be further developed for bioremediation and biological enzyme industrial production