Contaminated feed-borne Bacillus cereus aggravates respiratory distress post avian influenza virus H9N2 infection by inducing pneumonia

Avian influenza virus subtype H9N2 is identified in chickens with respiratory disease while Bacillus cereus (B. cereus) has been frequently isolated from chicken feed in China. However, the roles of co-infection with these two pathogens remain unclear. In the present study, SPF chicks were intragastrically administered with 108 CFU/mL of B. cereus for 7 days and then inoculated intranasally with 100 EID50 of H9N2 three days later. Alternatively, chickens were initially inoculated with H9N2 and then with B. cereus for one week. Post administration, typical respiratory distress persisted for 5 days in both co-infection groups. Gizzard erosions developed in the groups B. cereus/H9N2 and B. cereus group on 7th day while in group H9N2/B. cereus on 14th day. More importantly, both air-sac lesions and lung damage increased significantly in the co-infection group. Significant inflammatory changes were observed in the B. cereus group from day 7 to day 21. Moreover, higher loads of H9N2 virus were found in the co-infected groups than in the H9N2 group. Newcastle Disease Virus (NDV) specific antibodies were decreased significantly in the H9N2/B. cereus group compared to the B. cereus and the B. cereus/ H9N2 groups. Nonspecific IgA titers were reduced significantly in the B. cereus group and the H9N2/B. cereus group compared to the control group. In addition to this, lower lymphocyte proliferation was found in the con-infection groups and the H9N2 group. Hence, feed-borne B. cereus contamination potentially exacerbates gizzard ulceration and aggravates H9N2-induced respiratory distress by inhibiting antibody-mediated immunity and pathogen clearance. Thus controlling the B. cereus contamination in poultry feed is immediately needed.http://www.nature.com/scientificreportsam2019Paraclinical Science

Partial portfolio disclosure, investors’ attention, and window dressing

I show that the disclosure of mutual funds’ holdings significantly affects investors’ investment decisions. As most mutual fund websites, advertisements, and fund-trading platforms only disclose a fund’s 10 largest holdings (top-10), this study finds that investors disproportionately focus on these stocks. However, this bias does not lead to additional profit because relative to their peers, funds with good top-10 performance tend to generate poor long-term returns. I design a clean and innovative discontinuity test between the performance of the 10th and 11th portfolio holdings to examine such window dressing behavior. I find that relative to their peers, funds that are small, new, and highly active are more likely to window dress and incur greater costs if they suffer from severe capital outflows. My findings suggest that partial disclosure misleads investors and allows effective window dressing

The Commodification of Chinese in Thailand’s Linguistic Market: A Case Study of How Language Education Promotes Social Sustainability

In recent decades, the commodification of the English language has aroused intensive research interest in the sociolinguistics on a global scale, but studies on the commodification of the Chinese language are relatively rare. Most studies take a critical approach in relation to its adverse impacts on minority rights and social justice. This study examined the language landscape in Chiangmai, Thailand, and the linguistic beliefs of local Thai Chinese language learners. Based on their feedback, this study investigated the commodification of Chinese language education in the community of Chinese language learners in Chiangmai. We found that from a less critical perspective, the commodification of a second language provides more accessible and affordable educational opportunities for learners, especially those from low-income families, and at the same time language proficiency can broaden learners’ career choices and provide employees with additional value in industries, such as tourism, commerce, and services. This finding implies that language commodification, rather than typically being associated with linguistic imperialism and unbalanced socio-economic status, can be a contributing factor in promoting higher-education availability and social sustainability in certain circumstances. There may be some mediating factors between the commodification of language and changes in the sustainable balance of language, opening up space for future research to explore

Effects of Different Intercropping Models on Growth and Yield Traits of Maize in Red Soil Dryland

In order to develop the suitable planting mode of maize in red soil dryland, improve the related plant and ear characters of maize, promote high quality and high yield, and improve economic benefits. The experiment was conducted in the Science and Technology Park of Jiangxi Agricultural University from May 13, 2020 to October 18, 2020 and from May 5, 2021 to October 7, 2021. Taking maize as the control, three intercropping treatments of maize intercropping soybean, maize intercropping peanut and maize intercropping sweet potato were set up to compare their effects on agronomic characters such as plant height, stem diameter and ear width of maize and yield. The results showed that the plant height and ear height of maize intercropping soybean reached the maximum in two years, with plant height of 208.9 cm and 191.9 cm, ear height of 80.2 cm and 58.4 cm, respectively. The ear length and grain number per row of intercropping treatment were better than that of monoculture treatment. The ear length of maize intercropping and soybean reached the maximum, which were 16.5 cm and 19.0 cm respectively, and the grain number per row was also higher than that of other treatments. The yield of maize intercropping soybean was the highest, 42.1 kg and 43.5 kg respectively in two years. Compared with monoculture, intercropping can improve stem diameter, ear height, ear length, grain number per row and other ear traits, so as to improve corn yield, among which maize intercropping soybean is the best. The results of grey correlation showed that ear length and plant height had a great influence on maize yield. The comprehensive analysis shows that the use of maize intercropping soybean model is conducive to achieve high quality and high yield

Influence of Animal/Plant Activated Biochar Properties on Methane Production from Corn Stalk by Anaerobic Fermentation

Activated biochar (ABC) was prepared from typical plant/animal biochar (pig bone biochar/corn stalk biochar) by optimizing the gas production characteristics of anaerobic fermentation. The effects of the physical and chemical properties (specific surface area, surface functional group and conductivity) of ABC on the gas production characteristics of anaerobic fermentation were investigated. The results showed that the effect of pig-bone activated biochar (PABC) on anaerobic fermentation gas production characteristics was better than that of corn-stalk activated biochar (CABC). The peak period of gas production or methane production was up to 4 days earlier than that of the control group, and the cumulative methane production was up to 68% higher; this can shorten the fermentation period for up to 7 days, and the effect of stabilizing pH is better. In addition, the surface functional groups are not the dominant factors affecting the gas production characteristics, but the effects of conductivity and specific surface area cannot be neglected. For most experimental groups, when the specific surface area of PABC is more than 90 m2/g and the specific surface area of CABC is more than 100 m2/g. Methane production increases with the specific surface area increases and the controllable range of CBAC is relatively wider than that of PBAC. When the conductivity of CABC is more than 650 μS/cm and the conductivity of PABC is more than 1000 μS/cm, the conductivity has a positive correlation with methane production

Medical supervised masked autoencoders: Crafting a better masking strategy and efficient fine-tuning schedule for medical image classification

Masked autoencoders (MAEs) have displayed significant potential in the classification and semantic segmentation of medical images in the last year. Due to the high similarity of human tissues, even slight changes in medical images may represent diseased tissues, necessitating fine-grained inspection to pinpoint diseased tissues. The random masking strategy of MAEs is likely to result in areas of lesions being overlooked by the model. At the same time, inconsistencies between the pre-training and fine-tuning phases impede the performance and efficiency of MAE in medical image classification. To address these issues, we propose a medical supervised masked autoencoder (MSMAE) in this paper. In the pre-training phase, MSMAE precisely masks medical images via the attention maps obtained from supervised training, contributing to the representation learning of human tissue in the lesion area. During the fine-tuning phase, MSMAE is also driven by attention to the accurate masking of medical images. This improves the computational efficiency of the MSMAE while increasing the difficulty of fine-tuning, which indirectly improves the quality of MSMAE medical diagnosis. Extensive experiments demonstrate that MSMAE achieves state-of-the-art performance in case with three official medical datasets for various diseases. Meanwhile, transfer learning for MSMAE also demonstrates the great potential of our approach for medical semantic segmentation tasks. Moreover, the MSMAE accelerates the inference time in the fine-tuning phase by 11.2% and reduces the number of floating-point operations (FLOPs) by 74.08% compared to a traditional MAE

Changes in Nutrient Profile and Antioxidant Activities of Different Fish Soups, Before and After Simulated Gastrointestinal Digestion

Different kinds of freshwater fish soups show a diverse range of health functions, due to their different nutritional substances and corresponding bioactivities. In the current study, in order to learn the theoretical basis of the potential role fish soup plays in diet therapy functions, the changes of nutrient profiles and antioxidant activities in crucian carp soup and snakehead soup (before and after simulated gastrointestinal digestion) were investigated, such as chemical composition, free amino acids, mineral and fatty acid contents, DPPH radical scavenging activity, ferrous ion chelating activity, hydroxyl radical-scavenging activity and the reducing power effect. Results show that the content of mineral elements in snakehead fish soup was significantly higher than that of crucian carp soup, especially for the contents of Ca, Zn, Fe. The content of total amino acid (TAA) of crucian carp soup (82.51 mg/100 mL) was much higher than that of snakehead fish soup (47.54 mg/100 mL) (p < 0.05). Furthermore, the antioxidant capacity of crucian carp soup was stronger than that of snakehead soup. The intensive profiles of nutritional composition and antioxidant activities of these two kinds of fish soups were expected to partly provide the theoretical basis of therapeutic effects

Increased Serum Concentrations of TNF-Like Weak Inducer of Apoptosis Predict Higher 28-Day Mortality in Patients with Sepsis

We performed the current study to explore potential predictive value of serum Tumor Necrosis Factor- (TNF-) like weak inducer of apoptosis (TWEAK) concentrations for 28-day mortality in patients with sepsis. Adult septic patients (age≥18 years) admitted to a general ICU between November 2016 and October 2017 were consecutively included in our prospective observational study. TWEAK concentrations were detected in septic patients and healthy controls. Dynamic changes of TWEAK concentrations between 1st day and 3rd day of admission to ICU (ΔTWEAK concentrations) were also measured. A total of 79 septic patients were included and 19 of them (24.1%) died after a follow-up period of 28 days. We identified arterial lactate, NT-proBNP, and male gender as independent factors for 28-day mortality of patients with sepsis. The serum levels of TWEAK were significantly lower in septic patients compared to controls (417.4 ± 196.7 pg/ml versus 1243.8 ± 174.3 pg/ml, p<0.001). We found a positive correlation between TWEAK concentrations and SOFA score (Spearman correlation coefficient 0.235, p=0.037). Area under the receiver operating characteristic curve (AUROC) of ΔTWEAK concentrations for 28-day mortality was 0.754 (95% CI 0.645–0.844). We also evaluated the diagnostic performance of combinative index (ΔTWEAK concentrations and lactate) and obtained an AUROC of 0.860 (95% CI 0.763-0.928). In conclusion, our study found lower TWEAK concentrations in septic patients than those in healthy controls. Furthermore, the increased TWEAK concentrations during disease process predict higher 28-day mortality in septic patients. Dynamic changes of TWEAK should be an important supplement for current prognostic markers