5,335 research outputs found
Calculations of Resonance Coupling Constants in the Scalar Sector of the ENJL Model
We derive the scalar resonance coupling constants of resonance chiral theory
from the Extended Nambu Jona-Lasinio model by using heat-kernel expansion.Comment: 7 page
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Congenital myasthenic syndrome in Golden Retrievers is associated with a novel COLQ mutation.
BackgroundCongenital myasthenic syndromes (CMSs) are a group of inherited disorders of neuromuscular transmission that may be presynaptic, synaptic, or postsynaptic. Causative mutations have been identified in 4 breeds including the Labrador Retriever, Jack Russell Terrier, Heideterrier, and Danish Pointing Dog.Hypothesis/objectiveClinical and genetic characterization of a neuromuscular disorder in Golden Retriever (GR) puppies.AnimalsFour GR puppies from California were evaluated for generalized muscle weakness beginning at weaning. Biological specimens were collected from the affected puppies, and familial information was obtained. Blood or buccal swabs were obtained from 63 unaffected GRs.MethodsComplete physical, neurological, electrodiagnostic, and histological evaluations and biochemical quantification of muscle acetylcholine receptors were performed. Polymerase chain reaction was used to amplify the 17 exons of COLQ, and sequences were obtained by Sanger sequencing. Variant frequency was assessed in unrelated GRs and a public database.ResultsClinical, neurological, and electrodiagnostic evaluations confirmed a disorder of neuromuscular transmission in a GR family. Sequencing of all exons and splice sites of a primary candidate gene, COLQ, identified a point mutation that predicts an amino acid substitution (G294R). The primary COLQ transcript was absent from affected muscle samples. All affected puppies were homozygous for the mutation, which was not detected outside this GR family or in other breeds.Conclusions and clinical importanceWe confirmed the diagnosis of a CMS in GR puppies and identified a novel COLQ mutation. The COLQ gene encodes the collagenous tail of acetylcholinesterase, the enzyme responsible for termination of skeletal muscle contraction by clearing acetylcholine at the neuromuscular junction. Clinicians and breeders should be aware of this CMS in GR puppies with an early onset of weakness
Multifractal analysis of complex networks
Complex networks have recently attracted much attention in diverse areas of
science and technology. Many networks such as the WWW and biological networks
are known to display spatial heterogeneity which can be characterized by their
fractal dimensions. Multifractal analysis is a useful way to systematically
describe the spatial heterogeneity of both theoretical and experimental fractal
patterns. In this paper, we introduce a new box covering algorithm for
multifractal analysis of complex networks. This algorithm is used to calculate
the generalized fractal dimensions of some theoretical networks, namely
scale-free networks, small world networks and random networks, and one kind of
real networks, namely protein-protein interaction networks of different
species. Our numerical results indicate the existence of multifractality in
scale-free networks and protein-protein interaction networks, while the
multifractal behavior is not clear-cut for small world networks and random
networks. The possible variation of due to changes in the parameters of
the theoretical network models is also discussed.Comment: 18 pages, 7 figures, 4 table
History Dependent Phenomena in the Transverse Ising Ferroglass: the Free Energy Landscape
In this paper we investigate the relationship between glassy and
ferromagnetic phases in disordered Ising ferromagnets in the presence of
transverse magnetic fields, . Iterative mean field simulations probe
the free energy landscape and suggest the existence of a glass transition as a
function of which is distinct from the Curie temperature. New
experimental field-cooled and zero-field-cooled data on LiHoYF
provide support for our theoretical picture.Comment: 4 pages RevTex; 5 figure
Muscle Expression of Mutant Androgen Receptor Accounts for Systemic and Motor Neuron Disease Phenotypes in Spinal and Bulbar Muscular Atrophy
SummaryX-linked spinal and bulbar muscular atrophy (SBMA) is characterized by adult-onset muscle weakness and lower motor neuron degeneration. SBMA is caused by CAG-polyglutamine (polyQ) repeat expansions in the androgen receptor (AR) gene. Pathological findings include motor neuron loss, with polyQ-AR accumulation in intranuclear inclusions. SBMA patients exhibit myopathic features, suggesting a role for muscle in disease pathogenesis. To determine the contribution of muscle, we developed a BAC mouse model featuring a floxed first exon to permit cell-type-specific excision of human AR121Q. BAC fxAR121 mice develop systemic and neuromuscular phenotypes, including shortened survival. After validating termination of AR121 expression and full rescue with ubiquitous Cre, we crossed BAC fxAR121 mice with Human Skeletal Actin-Cre mice. Muscle-specific excision prevented weight loss, motor phenotypes, muscle pathology, and motor neuronopathy and dramatically extended survival. Our results reveal a crucial role for muscle expression of polyQ-AR in SBMA and suggest muscle-directed therapies as effective treatments
Next-to-leading order QCD predictions for production at LHC
We calculate the complete next-to-leading order (NLO) QCD corrections to the
production in association with a jet at the LHC. We study the impacts
of the NLO QCD radiative corrections to the integrated and differential cross
sections and the dependence of the cross section on the
factorization/renormalization scale. We present the transverse momentum
distributions of the final -, Higgs-boson and leading-jet. We find that
the NLO QCD corrections significantly modify the physical observables, and
obviously reduce the scale uncertainty of the LO cross section. The QCD
K-factors can be 1.183 and 1.180 at the and
LHC respectively, when we adopt the inclusive event selection scheme with
, and . Furthermore, we make the comparison between the two scale
choices, and , and find the scale choice seems to be more
appropriate than the fixed scale .Comment: 18 pages, 7 figure
Entropy-Corrected Holographic Dark Energy
The holographic dark energy (HDE) is now an interesting candidate of dark
energy, which has been studied extensively in the literature. In the derivation
of HDE, the black hole entropy plays an important role. In fact, the
entropy-area relation can be modified due to loop quantum gravity or other
reasons. With the modified entropy-area relation, we propose the so-called
``entropy-corrected holographic dark energy'' (ECHDE) in the present work. We
consider many aspects of ECHDE and find some interesting results. In addition,
we briefly consider the so-called ``entropy-corrected agegraphic dark energy''
(ECADE).Comment: 11 pages, 2 tables, revtex4; v2: references adde
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