Simulation and evaluation of ecosystem service value along the Yellow River in Henan Province, China

The unprecedented growth in population and swift industrial advancements exert considerable strains on the ecosystem, particularly within medium-sized and large urban landscapes. The critical investigation into the intricate links between current and prospective land utilization, as well as the ecosystem service value (ESV), holds considerable empirical relevance for the calibration of land usage frameworks, thereby contributing to the sustainable evolution of extensive urban zones. Utilizing GlobeLand 30 data, the present research probes into the pattern of land transformation and the spatial-temporal dispersal of ESV in Henan’s Yellow River vicinity over a span from 2000 to 2020. For the enhancement of land usage alignment, a Markov-PLUS fusion model was devised to gauge three disparate ESV transition scenarios slated for 2030, namely, natural development scenario (NDS), cropland protection scenario (CPS), and ecological protection scenario (EPS). The principal determinants of land transformation within the 2000–2020 period were recognized as elevation, populace concentration, and atmospheric temperature. Amid the rapid accretion of construction land engulfing substantial cropland and grassland areas, there was an ESV diminution to the tune of 1.432 billion RMB between 2000 and 2020. The ESV’s high-value regions were discerned within relatively undisturbed ecosystem zones, with the lower-value sections identified in cropland and constructed areas, where human interventions exerted pronounced effects on the ecosystem. In accordance with the 2030 land usage simulations and analyses, in contrast to alternative scenarios, the EPS exhibited the least fluctuation in land type alterations in 2030, demonstrated the most pronounced escalation in cold spot concentration, and reached a peak agglomeration level. This underscores that the EPS not only offers a refinement in land utilization configuration but also mediates the equilibrium between economic and ecological considerations. The insights derived from this investigation afford innovative evaluative methods for spatial planning, ecological recompense, and sustainable land exploitation within large- and medium-scale urban domains

Towards an Operative Predictive Model for the Songshan Area during the Yangshao Period

The literature in the field of archaeological predictive models has grown in the last years, looking for new factors the most effective methods to introduce. However, where predictive models are used for archaeological heritage management, they could benefit from using a more speedy and consequently useful methods including some well-consolidated factors studied in the literature. In this paper, an operative archaeological predictive model is developed, validated and discussed, in order to test its effectiveness. It is applied to Yangshao period (5000–3000 BC) in the Songshan area, where Chinese civilization emerged and developed, and uses 563 known settlement sites. The satisfactory results herein achieved clearly suggest that the model herein proposed can be reliably used to predict the geographical location of unknown settlements

Down-Regulation of EBV-LMP1 Radio-Sensitizes Nasal Pharyngeal Carcinoma Cells via NF-κB Regulated ATM Expression

BACKGROUND:The latent membrane protein 1 (LMP1) encoded by EBV is expressed in the majority of EBV-associated human malignancies and has been suggested to be one of the major oncogenic factors in EBV-mediated carcinogenesis. In previous studies we experimentally demonstrated that down-regulation of LMP1 expression by DNAzymes could increase radiosensitivity both in cells and in a xenograft NPC model in mice. RESULTS:In this study we explored the molecular mechanisms underlying the radiosensitization caused by the down-regulation of LMP1 in nasopharyngeal carcinoma. It was confirmed that LMP1 could up-regulate ATM expression in NPCs. Bioinformatic analysis of the ATM ptomoter region revealed three tentative binding sites for NF-κB. By using a specific inhibitor of NF-κB signaling and the dominant negative mutant of IkappaB, it was shown that the ATM expression in CNE1-LMP1 cells could be efficiently suppressed. Inhibition of LMP1 expression by the DNAzyme led to attenuation of the NF-κB DNA binding activity. We further showed that the silence of ATM expression by ATM-targeted siRNA could enhance the radiosensitivity in LMP1 positive NPC cells. CONCLUSIONS:Together, our results indicate that ATM expression can be regulated by LMP1 via the NF-κB pathways through direct promoter binding, which resulted in the change of radiosensitivity in NPCs

Serum prolactin and gonadal hormones in hemodialysis women: a meta-analysis

Abstract Background A meta-analysis followed by PRISMA 2020 statement was performed aiming to present a whole prolactin and sex hormone profile in hemodialysis women. Methods Literatures were searched in PubMed, Cochrane library, Embase, and Web of science before March 11, 2023. Trial sequential analysis (TSA) was performed to test the conclusiveness of this meta-analysis. Egger’s test and trim-and-fill analysis was used to test publication bias. We took standardized mean difference (SMD) as pool effect of hormones values including prolactin (PRL), follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2) and progesterone (P). This study was registered in PROSPERO and the number was CRD42023394503. Results Twenty-two articles from 13 countries were analyzed. Combining the results of TSA and meta-analysis, we found that compared with healthy control, hemodialysis women had higher PRL, follicular FSH and LH values and lower P levels (PRL: I 2  = 87%, SMD 1.24, 95% CI: 0.79–1.69, p < 0.00001; FSH: I 2  = 0%, SMD 0.34, 95% CI: 0.13–0.55, p = 0.002; LH: I 2  = 39%, SMD 0.64, 95% CI: 0.34–0.93, p < 0.00001; P: I 2  = 30%, SMD − 1.62, 95% CI: -2.04 to -1.20, p < 0.00001). What’s more, compared with women after renal transplantation, hemodialysis women had higher PRL levels (I 2  = 0%, SMD 0.51, 95% CI: 0.25–0.78, p = 0.0001). There was not enough evidence to draw a conclusion on the comparison of hormones between regular and irregular menses hemodialysis women. Egger’s test and trim-and-fill analysis didn’t show significant publication bias. Conclusions Hemodialysis women had higher serum PRL, follicular phase FSH, LH and lower serum P values compared with healthy control. PRL values of hemodialysis women were also higher than that of women after renal transplantation

Antibody Profiles Characteristic of Mycobacterium tuberculosis Infection State

The relationship between specific antibody profiles and tuberculosis (TB) state was investigated by measuring serum antibody levels to six Mycobacterium tuberculosis antigens in human subjects grouped into four diagnostic categories: active disease, inactive (past) tuberculosis, latent infection without radiographic chest abnormalities, and infection free. Statistical data analyses showed that the latter two groups were serologically indistinguishable and that active tuberculosis and inactive tuberculosis were characterized by different antibody profiles. Antibodies to the 38-kDa antigen, alanine dehydrogenase, and Rv2626c were associated with active TB, while antibodies to the 16-kDa antigen, ferredoxin A, and ESAT-6 were associated with inactive TB. Thus, the targets of the immune response vary with tuberculosis state. The correlation between bacterial antigen production and infection stage was investigated in mice infected with M. tuberculosis by bacterial transcription profiling. It was found that levels of transcripts encoding the six M. tuberculosis antigens varied during infection. Together, the data indicate that antigen composition of tubercle bacilli varies with stage of infection and that immunoprofiling can distinguish between tuberculosis states