20 research outputs found
Prevalence and Correlates of Discomfort and Acceptability of Acupuncture among Outpatients in Chinese Acupuncture and Moxibustion Departments: A Cross-Sectional Study
Objective. This study aims to give a profile of discomfort and acceptability of acupuncture, including the prevalence and association with demographic and acupuncture-related factors. Methods. A cross-sectional study was conducted in Beijing, China. Outpatients of acupuncture and moxibustion departments were recruited using purposive sampling. 925 subjects were interviewed with an anonymous questionnaire. Multinomial and binary logistic regression were used to analyze factors affecting discomfort and acceptability of acupuncture. Results. The average VAS value of 925 subjects’ acupuncture discomfort was 2.66 ± 2.02, within the range of mild discomfort. Acupuncture was easily accepted by 81.1% of the subjects. Results of logistic regression were as follows: (1) subjects with a better knowledge of acupuncture, or a greater fear of pain or needles, experienced more “moderate to severe discomfort” and showed a decreased acupuncture acceptance (P<0.001 or P<0.01); (2) Acupuncture with less discomfort or implemented by a more qualified doctor was easy to be accepted (P<0.001); (3) subjects aged 20–29 preferred to report “moderate to severe discomfort” while those aged 40–59 preferred to report “slight discomfort” (P<0.001). Conclusion. Acupuncture is an acceptable therapy with less discomfort, which can be greatly affected by fear of pain or needles, age, knowledge of acupuncture, and professional title of acupuncturist
Prodrug design, synthesis and pharmacokinetic evaluation of (3′R, 4′R)-3-hydroxymethyl-4-methyl-3′, 4′-di-O-(S)-camphanoyl-(+)-cis-khellactone
3-Hydroxymethyl-4-methyl-DCK (3, HMDCK) was discovered previously as a potent HIV non-nucleoside reverse transcriptase inhibitor (NNRTIs) (EC50: 0.004 μM, TI: 6225) with a novel mechanism of action. It exerts anti-HIV activity by inhibiting the production of HIV-1 double-stranded viral DNA from a single-stranded DNA intermediate, rather than blocking the generation of single-stranded DNA from a RNA template, which is the mechanism of action of current HIV-1 RT inhibitors. However, the insufficient metabolic stability of 3 limits its further clinical development. In the current study, a series of ester prodrugs of 3 was designed and synthesized to explore the new drug candidates as NNRTIs. The l-alanine ester prodrug 10 exhibited desirable pharmacokinetic properties in vitro and in vivo and showed improved oral bioavailability of 26% in rat, and would be a potential clinical candidate as a new anti-AIDS drug
The role of 245 phase in alkaline iron selenide superconductors revealed by high pressure studies
Here we show that a pressure of about 8 GPa suppresses both the vacancy order
and the insulating phase, and a further increase of the pressure to about 18
GPa induces a second transition or crossover. No superconductivity has been
found in compressed insulating 245 phase. The metallic phase in the
intermediate pressure range has a distinct behavior in the transport property,
which is also observed in the superconducting sample. We interpret this
intermediate metal as an orbital selective Mott phase (OSMP). Our results
suggest that the OSMP provides the physical pathway connecting the insulating
and superconducting phases of these iron selenide materials.Comment: 32 pages, 4 figure
A desinstitucionalização e as alternativas habitacionais ao dispor de indivíduos com perturbações mentais: Um novo modelo habitacional – A habitação apoiada
Desde o início do processo de desinstitucionalização desinstitucionalização
que este se tem vindo a deparar com dificuldades.
Passando pelos poucos recursos ao dispor dos serviços
de saúde mental, à tendência para trabalhar com os
elementos que apresentam maiores probabilidades de
sucesso, à não articulação entre os serviços hospitalares
e os centros comunitários de saúde mental, até à
falta de investimentos em alternativas habitacionais de
carácter permanente. Estas têm sido algumas das situações
a que os consumidores de serviços de saúde mental
se têm sujeitado.
Actualmente, assistimos à emergência de um paradigma
que assenta na crença de que se deverá prestar
apoio a estes consumidores numa casa tipicamente
normal, com uma vivência na comunidade, em que o
apoio é disponibilizado consoante as necessidades de
cada indivíduo sem que exista uma limitação temporal
à sua prestação. Torna-se assim necessário criar novos
papéis para os técnicos, no sentido de que estes ajudem
os consumidores a escolher, a obter, e a manter
uma habitação. É pois urgente o desenvolvimento de
um conjunto diversificado de alternativas habitacionais
que se baseiem nos recursos e capacidades das comunidades
locais, no sentido de garantir que o processo
de desinstitucionalização se conclua com sucesso.
Palavras-chave: desinstitucionalização, habitação
apoiada, satisfação dos consumidores, doença mental.ABSTRACT: Since its beginning the deinstitutiondeinstitutionalization process
has faced some difficulties, such as the mental
health services lack of resources, the trend to work
with the individual who presents higher probability of
success, the lack of articulation between hospital services
and community mental health centers, and the
lack of investments on accommodations for long periods
of time. These are some of the situations that
consumers of mental health services have endured.
Nowadays we witness the emerging of a paradigm
which lies on the idea that these consumers need to be
supported at a ordinary house, living in community,
where the support is provided according to each person’s
needs, and without a time limit. This paradigm
also creates a need for the professionals to find new
roles so that they will be able to help the consumers to
choose, get, and keep a home. To ensure the success of
deinstitutionalization it is vital that the establishment
of different alternatives of accommodation be based on
communities’ resources and capabilities.info:eu-repo/semantics/publishedVersio
Robust magnetism against pressure in non-superconducting samples prepared from lutetium foil and H2/N2 gas mixture
Recently, the claim of "near-ambient superconductivity" in a N-doped lutetium
hydride attracted enormous following-up investigations in the community of
condensed matter physics and material sciences. But quite soon, the
experimental results from different groups indicate consistently that no
evidence of near-ambient superconductivity is found in the samples synthesized
by the same method as the reported one, or by the other alternative methods.
From our extended high-pressure heat capacity and magnetic susceptibility
measurements on the samples prepared with the lutetium foil and H2/N2 gas
mixture, we report the finding of a magnetic transition at the temperature
about 56 K. Our results show that this magnetic phase is robust against
pressure up to 4.3 GPa, which covers the critical pressure of boosting the
claimed near room temperature superconductivity.Comment: 14 pages, 4 figure
Effect of Different Water Treatments in Soil-Plant-Atmosphere Continuum Based on Intelligent Weighing Systems
In order to meet the needs of dynamic continuous monitoring of soil-plant-atmosphere continuum (SPAC), a new soil, plant, atmosphere analysis system has been established based on an intelligent weighing system (IWS). Four types of irrigation treatments (90%, 80%, 70%, and 60% of field capacity (FC)) were conducted on lettuce (Lactuca sativa var. ramosa Hort.) for two-season planting experiments. Regarding the soil, the relative system weight of IWS showed a significant linear correlation with the soil volumetric moisture content (SWC) (R2 = 0.64–0.94). When the SWC increased by 1.00%, the soil weight increased by 56–62 g. Regarding plants, the IWS also clearly reflected the changes in plant weight gain, transpiration rate, and stomatal conductance at different growth stages. After verification, the relative errors of the transpiration rate and stomatal conductance measured by the IWS were −9.60–22.30% and −7.20–22.20%, respectively. Regarding the atmospheric environment, the variation trend of the crop evapotranspiration (ETc) based on the IWS and the reference crop evapotranspiration (ET0) calculated with meteorological parameters were consistent. However, the numerical difference was in the uncertainty of the crop coefficient (Kc). The ETc of lettuce under the 80% FC treatment was the highest. Accordingly, a daily online measurement method for Kc was established. The Kc values of lettuce at different growth stages were 0.88, 1.22, and 2.43, respectively. The growth, yield, and water use efficiency (WUE) of crops under 80% FC treatment compared with other treatments significantly increased by 11.07–21.05%, 0.91–9.89%, and 2.16–15.80%, respectively. Therefore, the 80% FC was adopted as the irrigation low limit of potted lettuce. The experimental results provide a theoretical basis for further guiding crop irrigation
Effect of Different Water Treatments in Soil-Plant-Atmosphere Continuum Based on Intelligent Weighing Systems
In order to meet the needs of dynamic continuous monitoring of soil-plant-atmosphere continuum (SPAC), a new soil, plant, atmosphere analysis system has been established based on an intelligent weighing system (IWS). Four types of irrigation treatments (90%, 80%, 70%, and 60% of field capacity (FC)) were conducted on lettuce (Lactuca sativa var. ramosa Hort.) for two-season planting experiments. Regarding the soil, the relative system weight of IWS showed a significant linear correlation with the soil volumetric moisture content (SWC) (R2 = 0.64–0.94). When the SWC increased by 1.00%, the soil weight increased by 56–62 g. Regarding plants, the IWS also clearly reflected the changes in plant weight gain, transpiration rate, and stomatal conductance at different growth stages. After verification, the relative errors of the transpiration rate and stomatal conductance measured by the IWS were −9.60–22.30% and −7.20–22.20%, respectively. Regarding the atmospheric environment, the variation trend of the crop evapotranspiration (ETc) based on the IWS and the reference crop evapotranspiration (ET0) calculated with meteorological parameters were consistent. However, the numerical difference was in the uncertainty of the crop coefficient (Kc). The ETc of lettuce under the 80% FC treatment was the highest. Accordingly, a daily online measurement method for Kc was established. The Kc values of lettuce at different growth stages were 0.88, 1.22, and 2.43, respectively. The growth, yield, and water use efficiency (WUE) of crops under 80% FC treatment compared with other treatments significantly increased by 11.07–21.05%, 0.91–9.89%, and 2.16–15.80%, respectively. Therefore, the 80% FC was adopted as the irrigation low limit of potted lettuce. The experimental results provide a theoretical basis for further guiding crop irrigation
Moxibustion using different habitat moxa floss for moderate to severe primary knee osteoarthritis: study protocol for a three-armed randomized, double-blinded, sham-controlled trial
Abstract Background According to the traditional Chinese medicine theory, moxa floss is the best material for moxibustion; the effect of moxibustion is closely related to the habitats of moxa floss, among which Qichun County, Hubei Province, China, is considered as the genuine origin. However, this view has not been validated by clinical studies. Moxibustion has been proven effective in alleviating pain and improving physical function and quality of life for patients with knee osteoarthritis (KOA). This trial aims to determine whether the habitat of moxa floss contributes to the effect of moxibustion and to validate the effectiveness of moxibustion for KOA. Methods This is a three-armed, randomized, double-blinded, sham-controlled trial. A total of 350 patients with moderate to severe primary KOA will be randomly allocated to groups A, B, or C with a 2:2:1 ratio. Moxa stick moxibustion using moxa floss from different habitats will be applied in two experimental groups: group A, moxa floss from the habitat of Qichun County, Hubei Province, China; and group B, moxa floss from the habitat of Nanyang County, Henan Province. Group C will use non-moxa floss for sham moxibustion as control. Patients will be treated for 20 min per session, for three sessions per week for 2 weeks, and followed up for 4 weeks. The primary outcome will be the change from baseline in the pain score of the Western Ontario and McMaster Osteoarthritis Index (WOMAC) at week 2. Secondary outcomes will include a change in the WOMAC pain score at week 6; the visual analogue scale for knee pain, the total WOMAC score, the WOMAC stiffness score, the WOMAC function score, the patient global assessment, and the responder criteria at weeks 2 and 6. Adverse events will be assessed throughout the study. Discussion This trial will help to identify the effectiveness of moxibustion for KOA and whether the habitat of moxa floss contributes to the effect of moxibustion. Trial registration Acupuncture-Moxibustion Clinical Trial Registry: AMCTR-IOR-16000007. Registered on 29 February 2016
Dynamic diffraction effects and coherent breathing oscillations in ultrafast electron diffraction in layered 1T-TaSeTe
Anisotropic lattice movements due to the difference between intralayer and interlayer bonding are observed in the layered transition-metal dichalcogenide 1T-TaSeTe following femtosecond laser pulse excitation. Our ultrafast electron diffraction investigations using 4D-transmission electron microscopy (4D-TEM) clearly reveal that the intensity of Bragg reflection spots often changes remarkably due to the dynamic diffraction effects and anisotropic lattice movement. Importantly, the temporal diffracted intensity from a specific crystallographic plane depends on the deviation parameter s, which is commonly used in the theoretical study of diffraction intensity. Herein, we report on lattice thermalization and structural oscillations in layered 1T-TaSeTe, analyzed by dynamic diffraction theory. Ultrafast alterations of satellite spots arising from the charge density wave in the present system are also briefly discussed