2 research outputs found
Selective Monoesterification of Symmetrical Diols Using Resin-Bound Triphenylphosphine
Coupling reactions to make esters
and amides are among the most
widely used organic transformations. We report efficient procedures
for amide bond formation and for the monoesterification of symmetrical
diols in excellent yields without any requirement for high dilution
or slow addition using resin-bound triarylphosphonium iodide. Easy
purification, low moisture sensitivity, and good to excellent yields
of the products are the major advantages of this protocol