4 research outputs found
Association between diet-quality scores, adiposity, total cholesterol and markers of nutritional status in European adults: findings from the Food4Me study
Diet-quality scores (DQS), which are developed across the globe, are used to define adherence to specific eating patterns and have been associated with risk of coronary heart disease and type-II diabetes. We explored the association between five diet-quality scores (Healthy Eating Index, HEI; Alternate Healthy Eating Index, AHEI; MedDietScore, MDS; PREDIMED Mediterranean Diet Score, P-MDS; Dutch Healthy Diet-Index, DHDI) and markers of metabolic health (anthropometry, objective physical activity levels (PAL), and dried blood spot total cholesterol (TC), total carotenoids, and omega-3 index) in the Food4Me cohort, using regression analysis. Dietary intake was assessed using a validated Food Frequency Questionnaire. Participants (n = 1480) were adults recruited from seven European Union (EU) countries. Overall, women had higher HEI and AHEI than men (p < 0.05), and scores varied significantly between countries. For all DQS, higher scores were associated with lower body mass index, lower waist-to-height ratio and waist circumference, and higher total carotenoids and omega-3-index (p trends < 0.05). Higher HEI, AHEI, DHDI, and P-MDS scores were associated with increased daily PAL, moderate and vigorous activity, and reduced sedentary behaviour (p trend < 0.05). We observed no association between DQS and TC. To conclude, higher DQS, which reflect better dietary patterns, were associated with markers of better nutritional status and metabolic health
Mediterranean Diet Adherence and Genetic Background Roles within a Web-Based Nutritional Intervention: The Food4Me Study
Mediterranean Diet (MedDiet) adherence has been proven to produce numerous health
benefits. In addition, nutrigenetic studies have explained some individual variations in the response to
specific dietary patterns. The present research aimed to explore associations and potential interactions
between MedDiet adherence and genetic background throughout the Food4Me web-based nutritional
intervention. Dietary, anthropometrical and biochemical data from volunteers of the Food4Me study were collected at baseline and after 6 months. Several genetic variants related to metabolic risk features
were also analysed. A Genetic Risk Score (GRS) was derived from risk alleles and a Mediterranean
Diet Score (MDS), based on validated food intake data, was estimated. At baseline, there were no
interactions between GRS and MDS categories for metabolic traits. Linear mixed model repeated
measures analyses showed a significantly greater decrease in total cholesterol in participants with a
low GRS after a 6-month period, compared to those with a high GRS. Meanwhile, a high baseline
MDS was associated with greater decreases in Body Mass Index (BMI), waist circumference and
glucose. There also was a significant interaction between GRS and the MedDiet after the follow-up
period. Among subjects with a high GRS, those with a high MDS evidenced a highly significant
reduction in total carotenoids, while among those with a low GRS, there was no difference associated
with MDS levels. These results suggest that a higher MedDiet adherence induces beneficial effects on
metabolic outcomes, which can be affected by the genetic background in some specific markers
Association between diet-quality scores, adiposity, total cholesterol and markers of nutritional status in European adults: findings from the Food4Me study
Diet-quality scores (DQS), which are developed across the globe, are used to define adherence to specific eating patterns and have been associated with risk of coronary heart disease and type-II diabetes. We explored the association between five diet-quality scores (Healthy Eating Index, HEI; Alternate Healthy Eating Index, AHEI; MedDietScore, MDS; PREDIMED Mediterranean Diet Score, P-MDS; Dutch Healthy Diet-Index, DHDI) and markers of metabolic health (anthropometry, objective physical activity levels (PAL), and dried blood spot total cholesterol (TC), total carotenoids, and omega-3 index) in the Food4Me cohort, using regression analysis. Dietary intake was assessed using a validated Food Frequency Questionnaire. Participants (n = 1480) were adults recruited from seven European Union (EU) countries. Overall, women had higher HEI and AHEI than men (p < 0.05), and scores varied significantly between countries. For all DQS, higher scores were associated with lower body mass index, lower waist-to-height ratio and waist circumference, and higher total carotenoids and omega-3-index (p trends < 0.05). Higher HEI, AHEI, DHDI, and P-MDS scores were associated with increased daily PAL, moderate and vigorous activity, and reduced sedentary behaviour (p trend < 0.05). We observed no association between DQS and TC. To conclude, higher DQS, which reflect better dietary patterns, were associated with markers of better nutritional status and metabolic health
Mediterranean Diet Adherence and Genetic Background Roles within a Web-Based Nutritional Intervention: The Food4Me Study
Mediterranean Diet (MedDiet) adherence has been proven to produce numerous health
benefits. In addition, nutrigenetic studies have explained some individual variations in the response to
specific dietary patterns. The present research aimed to explore associations and potential interactions
between MedDiet adherence and genetic background throughout the Food4Me web-based nutritional
intervention. Dietary, anthropometrical and biochemical data from volunteers of the Food4Me study were collected at baseline and after 6 months. Several genetic variants related to metabolic risk features
were also analysed. A Genetic Risk Score (GRS) was derived from risk alleles and a Mediterranean
Diet Score (MDS), based on validated food intake data, was estimated. At baseline, there were no
interactions between GRS and MDS categories for metabolic traits. Linear mixed model repeated
measures analyses showed a significantly greater decrease in total cholesterol in participants with a
low GRS after a 6-month period, compared to those with a high GRS. Meanwhile, a high baseline
MDS was associated with greater decreases in Body Mass Index (BMI), waist circumference and
glucose. There also was a significant interaction between GRS and the MedDiet after the follow-up
period. Among subjects with a high GRS, those with a high MDS evidenced a highly significant
reduction in total carotenoids, while among those with a low GRS, there was no difference associated
with MDS levels. These results suggest that a higher MedDiet adherence induces beneficial effects on
metabolic outcomes, which can be affected by the genetic background in some specific markers