The Bank’s Financially Stable Supply Chain as the Basis for Attraction of Investors

In this article the authors is examined a key conceptual apparatus and basis indicators of evaluation of the financial stability of supply chain in banks, methods of evaluation of financial stability of banks, through which potential investors can improve the process of making a decision about the rationality of cooperation with a financial institution and investing funds in this financial institution. Revealed main advantages and disadvantages of the suggested in this article method of analysis of banks financial stability of supply chain and formed a conclusion. In this article the authors formed the key purposes of carrying out the analysis of financial stability of commercial banks, introduced the formulas for calculating the crucial coefficients of appraisal of supply chain financial stability and indicated their interpretation, described their advantages and drawbacks, also described automated application programs for evaluating the financial status of commercial banks, allowing you to visually see and assess the current situation in which the financial institution is located, and also allows you to make a forecast of development trends, through which it is possible to identify and how reliable, competitive, and therefore the banks financially stable supply chain, which is mainly attractive for potential investor

The Effect of L-Arginine on the Clinical and Immunological Parameters in Patients with Asthma

The purpose of this study was to study the effects of L-arginine on the clinical course and some immunological parameters in patients with asthma. Material and Methods: In this study, we examined 56 patients with moderate and severe persistent asthma. The duration of the disease ranged between 15+2. 3 years. The patients were divided into two groups. The patients of the study group (n=25) were subjected to the standard treatment and nitric oxide (NO) donor L-arginine. The patients of the comparison group (n=31) received the standard treatment only. All patients underwent a complete physical examination including a determination of serum cytokine levels (IL-4, IL-8, and TNF-α) both prior and post treatment. Results: In both groups, the baseline serum levels of IL-4, IL-8 and TNF-Fα were greater than the normative values. Direct correlations were observed between the level of the interleukins and clinical symptoms. Daily intravenous infusion of L-arginine at 4.2 g for 30 min over 10 days significantly reduced the serum levels of IL-4, IL-8 and TNF-α. No significant changes were noted in the levels of these parameters in the control group. Conclusion: The addition of L-arginine to the basic treatment in asthmatic patients contributed to the earlier improvement of clinical symptoms and a significant reduction of the IL-4, IL-8 and TNF-α serum levels

National and Cultural Specific Character of Veterinary Terms Motivation in Russian and Kazakh Languages

This article describes specific nature of discipline-specific term motivation in various languages. However, the issue on evolution and development tendencies of special veterinary vocabulary in the Russian and Kazakh languages has not been a subject of special researches and requires scientific description and learning. Veterinary terminology is a set of terms for all directions of the discipline, which conform to the necessary requirements specified to terms. Term motivation is directly analyzed in the article on examples of terms-zoonoses which are characteristic of epizootologic terminology as a branch of veterinary terminology. The cognitive aspect of this terminology presents the peculiarities of system development of special veterinary knowledge that have been formed continuously under the influence of internal and external socio-economic factors. The paper demonstrates the distinctions between the languages caused by distinction of occidental and oriental cultures on examples of untranslatable terms-zoonoses of the Russian and Kazakh languages. DOI: 10.5901/mjss.2015.v6n5s1p47

THE «WEALTH - POVERTY» OPPOSITION IN THE LINGUISTIC PICTURE OF THE WORLD (BASED ON THE MATERIAL OF KAZAKH AND TATAR PAREMIAS)

Background. This article examines the opposition of the concepts “baylyk-baylyk”, “kedeilik-yarlylyk” in the paremiological units of the Kazakh and Tatar languages. It is well known that proverbs are mostly closely related to the external factors of human life. Paremias react realistically to phenomena, reflect an ethnic worldview, and express philosophical, aesthetic, and religiously pragmatic folk views. Purpose. The aim of the study is to determine the features of the expression of the oppositional concepts “baylyk-baylyk”, “kedeilik-yarlylyk” in Kazakh and Tatar paroemias. Materials and methods. In the research work, a detailed analysis of proverbs and sayings of the Kazakh and Tatar languages containing units of lexical and semantic groups “baylyk-baylyk”, “kedeilik-yarlylyk” was carried out. The following research methods are used in the work: conceptual, diachronic analyses, methods of comparative linguoculturological analysis. Results. The concepts “baylyk-baylyk”, “kedeilik-yarlylyk” in the Kazakh and Tatar paremiological system represent both universal and specific features of the linguistic world pictures of the two peoples through various ethnospecific images. As a result of the study, it was revealed that these concepts in the paremias serve as a reflection not only of the material situation, but also of the spiritual state of a person. A brief dialogue with the use of paremias is instructive in nature and often asserts the priority of moral values over material goods. Practical implications. The results of the research can be used both in the main course of teaching Kazakh and Tatar languages, and in elective courses of cognitive linguistics, conceptology, literary studies, folklore, and can also be useful for research in the field of linguistic worldviews of the Kazakh and Tatar peoples

WNK1-OSR1 kinase-mediated phospho-activation of Na+-K+-2Cl- cotransporter facilitates glioma migration

Background: The bumetanide (BMT)-sensitive Na+-K+-2Cl- cotransporter isoform 1 (NKCC1) maintains cell volume homeostasis by increasing intracellular K+ and Cl- content via regulatory volume increase (RVI). Expression levels of NKCC1 positively correlate with the histological grade and severity of gliomas, the most common primary adult brain tumors, and up-regulated NKCC1 activity facilitates glioma cell migration and apoptotic resistance to the chemotherapeutic drug temozolomide (TMZ). However, the cellular mechanisms underlying NKCC1 functional up-regulation in glioma and in response to TMZ administration remain unknown. Methods: Expression of NKCC1 and its upstream kinases With-No-K (Lysine) kinase 1 (WNK1) and oxidative stress-responsive kinase-1 (OSR1) in different human glioma cell lines and glioma specimens were detected by western blotting and immunostaining. Live cell imaging and microchemotaxis assay were applied to record glioma cell movements under different treatment conditions. Fluorescence indicators were utilized to measure cell volume, intracellular K+ and Cl- content to reflect the activity of NKCC1 on ion transportation. Small interfering RNA (siRNA)-mediated knockdown of WNK1 or OSR1 was used to explore their roles in regulation of NKCC1 activity in glioma cells. Results of different treatment groups were compared by one-way ANOVA using the Bonferroni post-hoc test in the case of multiple comparisons. Results: We show that compared to human neural stem cells and astrocytes, human glioma cells exhibit robust increases in the activation and phosphorylation of NKCC1 and its two upstream regulatory kinases, WNK1 and OSR1. siRNA-mediated knockdown of WNK1 or OSR1 reduces intracellular K+ and Cl- content and RVI in glioma cells by abolishing NKCC1 regulatory phospho-activation. Unexpectedly, TMZ activates the WNK1/OSR1/NKCC1 signaling pathway and enhances glioma migration. Pharmacological inhibition of NKCC1 with its potent inhibitor BMT or siRNA knockdown of WNK1 or OSR1 significantly decreases glioma cell migration after TMZ treatment. Conclusion: Together, our data show a novel role for the WNK1/OSR1/NKCC1 pathway in basal and TMZ-induced glioma migration, and suggest that glioma treatment with TMZ might be improved by drugs that inhibit elements of the WNK1/OSR1/NKCC1 signaling pathway

Astana experience: department of oncohematology and bone marrow transplantation, National Research Center of Oncology and Transplantation

The Unit of Oncohematology and Bone Marrow Transplantation (BMT) was arranged on basis of the Republican Research Center of Hospital Emergencies SC (Astana, Republic of Kazakhstan) in August 2010. Since July 2014, a Clinical Department with 69 beds was arranged, and National Research Center for Oncology and Transplantation SC was arranged. From 2010 to 2016, the modalities of hematopoietic stem cell transplantation have been advanced, from autologous BMT to allogeneic hematopoietic stem cell transplants (HSCT) from matched donors (33%), and haploidentical HSCTs (43% in 2016), a total of 186 transpants. Bone marrow was used as a source of stem cells in 71 cases (71 donors for allo-HSCT in 69 recipients), whereas peripheral stem cells were harvested in 73 cases (15 donors for 15 recipients of allo-BMT, and 58 marrow harvests for autologous BMT)

Chromium(III) biosorption onto spent grains residual from brewing industry : equilibrium, kinetics and column studies

The use of industrial wastes for wastewater treatment as a strategy to their re-use and valorisation may provide important advances toward sustainability. The present work gives new insights into heavy metal biosorption onto low-cost biosorbents, studying chromium(III) biosorption onto spent grains residual from a Portuguese brewing industry both in batch and expanded bed column systems. Experimental studies involved unmodified spent grains and spent grains treated with NaOH. Metal uptake followed a rapid initial step, well described by the pseudo-second-order kinetic model up to 27 h, indicating chemisorption to be the rate-limiting step. Beyond this period intraparticle diffusion assumed an important role in the uptake global kinetics. The best fit for equilibrium data was obtained using the Langmuir model, with unmodified spent grains having the higher maximum uptake capacity (q max = 16.7 mg g1). In open system studies, using expanded bed columns, the best performance was also achieved with unmodified spent grains: Breakthrough time (C/C i = 0.25) and total saturation time (C/C i = 0.99) occurred after 58 and 199 h of operation, corresponding to the accumulation of 390 mg of chromium(III), 43.3 % of the total amount entering the column. These results suggest that alkali treatment does not improve spent grains uptake performance. Changes in biomass composition determined by Fourier transform infrared spectroscopy suggested hydroxyl groups and proteins to have an important role in chromium(III) biosorption. This study points out that unmodified spent grains can be successfully used as low-cost biosorbent for trivalent chromium.The authors would like to thank the Portuguese brewing industry UNICER for all the support and FCT (Fundacao para a Ciencia e a Tecnologia) financial support through the Grant PRAXIS XXI/BD/15945/98

Proangiogenic Effect of 2A-Peptide Based Multicistronic Recombinant Constructs Encoding VEGF and FGF2 Growth Factors

Coronary artery disease remains one of the primary healthcare problems due to the high cost of treatment, increased number of patients, poor clinical outcomes, and lack of effective therapy. Though pharmacological and surgical treatments positively affect symptoms and arrest the disease progression, they generally exhibit a limited effect on the disease outcome. The development of alternative therapeutic approaches towards ischemic disease treatment, especially of decompensated forms, is therefore relevant. Therapeutic angiogenesis, stimulated by various cytokines, chemokines, and growth factors, provides the possibility of restoring functional blood flow in ischemic tissues, thereby ensuring the regeneration of the damaged area. In the current study, based on the clinically approved plasmid vector pVax1, multigenic constructs were developed encoding vascular endothelial growth factor (VEGF), fibroblast growth factors (FGF2), and the DsRed fluorescent protein, integrated via picornaviruses’ furin-2A peptide sequences. In vitro experiments demonstrated that genetically modified cells with engineered plasmid constructs expressed the target proteins. Overexpression of VEGF and FGF2 resulted in increased levels of the recombinant proteins. Concomitantly, these did not lead to a significant shift in the general secretory profile of modified HEK293T cells. Simultaneously, the secretome of genetically modified cells showed significant stimulating effects on the formation of capillary-like structures by HUVEC (endothelial cells) in vitro. Our results revealed that when the multicistronic multigene vectors encoding 2A peptide sequences are created, transient transgene co-expression is ensured. The results obtained indicated the mutual synergistic effects of the growth factors VEGF and FGF2 on the proliferation of endothelial cells in vitro. Thus, recombinant multicistronic multigenic constructs might serve as a promising approach for establishing safe and effective systems to treat ischemic diseases

Sustained Na⁺/H⁺ exchanger activation promotes gliotransmitter release from reactive hippocampal astrocytes following oxygen-glucose deprivation

Hypoxia ischemia (HI)-related brain injury is the major cause of long-term morbidity in neonates. One characteristic hallmark of neonatal HI is the development of reactive astrogliosis in the hippocampus. However, the impact of reactive astrogliosis in hippocampal damage after neonatal HI is not fully understood. In the current study, we investigated the role of Na +/H+ exchanger isoform 1 (NHE1) protein in mouse reactive hippocampal astrocyte function in an in vitro ischemia model (oxygen/glucose deprivation and reoxygenation, OGD/REOX). 2 h OGD significantly increased NHE1 protein expression and NHE1-mediated H+ efflux in hippocampal astrocytes. NHE1 activity remained stimulated during 1-5 h REOX and returned to the basal level at 24 h REOX. NHE1 activation in hippocampal astrocytes resulted in intracellular Na+ and Ca2+ overload. The latter was mediated by reversal of Na+/Ca2+ exchange. Hippocampal astrocytes also exhibited a robust release of gliotransmitters (glutamate and pro-inflammatory cytokines IL-6 and TNFα) during 1-24 h REOX. Interestingly, inhibition of NHE1 activity with its potent inhibitor HOE 642 not only reduced Na+ overload but also gliotransmitter release from hippocampal astrocytes. The noncompetitive excitatory amino acid transporter inhibitor TBOA showed a similar effect on blocking the glutamate release. Taken together, we concluded that NHE1 plays an essential role in maintaining H + homeostasis in hippocampal astrocytes. Over-stimulation of NHE1 activity following in vitro ischemia disrupts Na+ and Ca2+ homeostasis, which reduces Na+-dependent glutamate uptake and promotes release of glutamate and cytokines from reactive astrocytes. Therefore, blocking sustained NHE1 activation in reactive astrocytes may provide neuroprotection following HI. © 2014 Cengiz et al

Active removal of waste dye pollutants using Ta[sub]3N[sub]5/W[sub]18O[sub]49 nanocomposite fibres

A scalable solvothermal technique is reported for the synthesis of a photocatalytic composite material consisting of orthorhombic Ta3N5 nanoparticles and WOx≤3 nanowires. Through X-ray diffraction and X-ray photoelectron spectroscopy, the as-grown tungsten(VI) sub-oxide was identified as monoclinic W18O49. The composite material catalysed the degradation of Rhodamine B at over double the rate of the Ta3N5 nanoparticles alone under illumination by white light, and continued to exhibit superior catalytic properties following recycling of the catalysts. Moreover, strong molecular adsorption of the dye to the W18O49 component of the composite resulted in near-complete decolourisation of the solution prior to light exposure. The radical species involved within the photocatalytic mechanisms were also explored through use of scavenger reagents. Our research demonstrates the exciting potential of this novel photocatalyst for the degradation of organic contaminants, and to the authors’ knowledge the material has not been investigated previously. In addition, the simplicity of the synthesis process indicates that the material is a viable candidate for the scale-up and removal of dye pollutants on a wider scale