A rare presentation of adrenal adenoma in infancy: isolated Cushing's syndrome

Adrenocortical tumors are rare in children. Most of these tumors present with endocrinological manifestations, majority of which with virilizing features alone or in combination with over production of other adrenal hormones. However, it is uncommon of an adrenocortical tumor to present solely with Cushing's syndrome. In this paper we discuss the clinical presentation and management of a 5-month-old infant who had presented with Cushing's syndrome due to a functioning adrenocortical adenoma without androgen and mineralocorticoid excess, and made a brief review on the clinical and histopathological characteristics of adrenocortical tumors

Classic Kaposi′s sarcoma with colonic involvement: A rare presentation with successful treatment with oral etoposide

Kaposi′s sarcoma (KS) is currently regarded as a low-grade vascular malignancy. KS is a multicentric and multisystem disease that involves the skin and less commonly visceral organs, such as the gastrointestinal system including colonic involvement. KS with colonic involvement in HIV-negative patients is a rare clinical manifestation. In this regard, we report an immunocompetent, HIV-negative elderly female patient with classic KS presenting with colonic involvement

Relapse of T-Cell Lymphoma as Isolated Brachial Plexus Neurolymphomatosis: A Case Report

Neurolymphomatosis (NL) is the neoplastic endoneurial invasion of the peripheral nervous system. It is a rare and challenging diagnosis, but it should be taken into account in the differential diagnosis of peripheral neuropathy, particularly in patients with a documented history of haematologic malignancy. Magnetic resonance (MR) neurography is very useful in diagnosis and especially when correlated with positron emission tomography/computed tomography (PET/CT). In equivocal cases, nerve biopsy can be considered when the benefit outweighs the risk. We aimed to report a case of a 30-year-old male patient who was in complete remission from T-lymphoblastic lymphoma, presenting with clinical findings indicating initially ulnar entrapment. However, with the demonstration of brachial plexopathy with axonal loss in electrodiagnostic studies, MR imaging neurography dedicated to brachial plexus was carried out and revealed pathological enhancement associated with mild fluorodeoxyglucose (FDG) uptake on PET/CT. Moreover, NL, due to the relapse of T-cell lymphoma, was diagnosed through incisional biopsy, showing diffuse infiltration of blast cells positive for terminal deoxynucleotidyl transferase, CD3 and CD10. Further, radiotherapy and systemic chemotherapy were initiated, and symptoms recovered with regression of pathological FDG uptake

Metastasis of Malignant Melanoma to Common Biliary Duct Demonstrated With F-18 FDG PET/CT

Malignant melanoma is well known for its propensity to spread to unpredictable sites. F-18 FDG PET can highlight metastases at unusual sites that may be missed with conventional imaging modalities. In this study, we present the case of a 57-year-old male patient who was referred to our department for PET/CT imaging because of metabolic characterization of the lesion located in distal common biliary duct and biopsied as malignant melanoma. His PET/CT images revealed a hypermetabolic lesion at the mentioned site. Interestingly, his images also showed mild FDG accumulation on right frontoparietal skin, and the biopsy of this lesion was also reported as malignant melanoma

Tongue metastasis of melanoma

Malignant melanoma may metastasize to virtually any organs. Metastases to the oral cavity are uncommon and tongue metastases are very rare. The patient was a 79-year-old woman with cutaneous malignant melanoma. Lesion was widely excised and lymph node dissection was performed. She also had adjuvant chemotherapy. She is the unique malignant melanoma case who had recurrence on tongue 10 years later in literature. In conclusion, the prognosis of patients with tongue metastasis is poor and most of these patients have underlying widespread diseases

Lipoadenoma of the Submandibular Gland.

We report a case of an oncocytic lipoadenoma of the submandibular gland, which is a very rare benign tumor of the salivary gland. The patient was a 36-year-old man with a right submandibular mass measuring 29 x 1.3 x 1.2 cm. When the pre-operative diagnostic tools were insufficient to rule out malignancy and for definite diagnosis, total removal of the gland was performed. Histopathologically, microscopic examination revealed a well-circumscribed tumor that is surrounded by a thin, fibrous capsule. The majority of the tumor consisted of adipocytes and normal components of salivary gland tissue. Oncocytic cells were observed only focally. Physicians should keep in mind that salivary glands may rarely exhibit this special tumor growth pattern

Primary extrahepatic bile duct lymphoma mimicking Klatskin’s tumor, dramatic response to chemotherapy

Introduction: Non- Hodgkin’s lymphoma (NHL) mimicking Klatskin’s tumor is rare but possible. It can be confused with tumors for which major surgery is needed. Imaging modalities have similar features in Klatskin’s tumor and non-Hodgkin’s lymphoma. Presentation of Case: We herein report a patient who was first thought having a Klatskin’s tumor and prepared for major surgery. A month later, obstructive jaundice developed and a second magnetic resonance-magnetic resonance cholangiopancreotography showed a doubling size of the tumor in one month. In terms of tumor behavior, lymphoma was suspected and a tru-cut biopsy was performed by interventional radiology. Pathological examinations revealed non-Hodgkin’s lymphoma large B-cell type. After 4 cycles of chemotherapy by hematology-oncology department, complete cure was achieved. Discussion: Since the radiologic and clinical features are confusable in Klatskin’s tumor and non-Hodgkin lymphoma. Tumor biologic behavior and other biochemical parameters together may put a suspicion in mind. Upon suspicion biopsy must be done radiologically. Conclusion: Primary liver lymphoma arising from the bile ducts is extremely rare and radiologic imaging features do not differ from cholangiocarcinoma. A strong suspicion may prevent unnecessary surgery. Since the treatment of non-Hodgkin’s lymphoma is mainly chemotherapy

Unicystic Ameloblastoma: A Case Report

Ameloblastoma is a tumor of odontogenic type, arising from the epithelium with fibrous stroma and enamel organ in different steps of evolution. Ameloblastoma represents 1 % of maxillary and mandibulary tumors and 11 % of odontogenic tumors. The age is most often between 20-50 years of age. There is no difference in prevalance between men and women. The molar-ramus region is the most frequent site of involvement