Two Cases of Dermatitis Herpetiformis Successfully Treated with Tetracycline and Niacinamide

No abstract available.</p

Pemphigus Foliaceus Complicated by Kaposi Varicelliform Eruption

No abstract available</p

Investigation of magnetic resonance coupling circuit topologies for wireless power transmission

© 2019 Wiley Periodicals, Inc. Magnetic resonance coupling circuits have four general topologies; however, there is a lack of comprehensive theoretical analysis with experimental verification for each of these topologies regarding their attractiveness for wireless power transfer (WPT). This article provides this for each of the four topologies to fully understand their differences and allow the selection of the most appropriate type based on system requirements. In addition, a problem associated with the resonance coupling method is the phenomenon of frequency splitting, which can lead to a high-power transfer efficiency but low-load power at the resonant frequency. Reasons for frequency splitting and methods of circumventing the problem will be illustrated in this article. Of the four topologies, the series-parallel (SP) (input-output) circuit configuration is the most efficient for the realization of a WPT system with a large load impedance, in terms of achieving both a high power transfer efficiency and high-load power

Experimental Research on Scour Protection Range and Protection Effect of Large Diameter Monopile Foundation

[Introduction] Under the wave-current combinations during the service period of offshore wind turbine, local scour inevitably occurs around pile foundation, which threatens the overall stability and safety of offshore wind turbine. [Method] In this paper, the normal physical model test at a scale of 1∶30 was carried out for the wind power foundation with a diameter of 8.0 m to study the scour depth, sand cover, solidified soil protection range, and protection effect. [Result] The results show that due to the good hydrodynamic conditions considered in this test, the maximum scour depth is 0.133 cm. In this case, the 1 cm-thick sand cover with a splicing size of 1.0 m×1.0 m can meet the stability requirements. When solidified soil is adopted for protection, the protection range shall not be less than 5 times the pile diameter, and block stones shall be laid at the edge of solidified soil to avoid scouring at the lower part of solidified soil. [Conclusion] The test results can provide reference for scouring test and engineering design of similar projects

Hyperglycemia Induced by Chronic Restraint Stress in Mice Is Associated With Nucleus Tractus Solitarius Injury and Not Just the Direct Effect of Glucocorticoids

Chronic restraint stress (CRS) can affect hypothalamic-pituitary-adrenal (HPA) axis activity and increase glucocorticoid levels. Glucocorticoids are stress hormones that regulate multiple aspects of energy homeostasis. Stress also impairs glucose tolerance. The aim of this study was to investigate the cause of insulin-resistant hyperglycemia during CRS. We produced the CRS models (a 7-day restraint followed by a 3-day free moving procedure, total of 4 cycles for 40 days) in mice, detected the parameters related to glucose metabolism, and compared them to those of the dexamethasone (DEX) injection (0.2 mg/kg i.p., also a 4 cycle procedure as the CRS). The results showed that the CRS induced a moderate (not higher than 11 mmol/L) and irreversible insulin-resistant hyperglycemia in about 1/3 of the individuals, and all the restrained mice had adrenal hypertrophy. CRS induced the apoptosis of neurons in the anterior part of commissural subnucleus of nucleus tractus solitarius (acNTS) in the hyperglycemic mice, and acNTS mechanical damage also led to insulin-resistant hyperglycemia. In contrast, in the DEX-treated mice, adrenal gland atrophy was evident. The glucose and insulin tolerance varied with the delay of determination. DEX exposure in vivo does not induce the apoptosis of neurons in NTS. This study indicates that restraint stress and DEX induce metabolic disorders through different mechanisms. During CRS, injury (apoptosis) of glucose-sensitive acNTS neurons cause dysregulation of blood glucose. This study also suggests the mouse restraint stress model has value as a potential application in the study of stress-induced hyperglycemia

Silencing of PTK7 in Colon Cancer Cells: Caspase-10-Dependent Apoptosis via Mitochondrial Pathway

Protein tyrosine kinase-7 (PTK7) is a catalytically inactive receptor tyrosine kinase (RTK). PTK7 is upregulated in many common human cancers, including colon cancer, lung cancer, gastric cancer and acute myeloid leukemia. The reason for this up-regulation is not yet known. To explore the functional role of PTK7, the expression of PTK7 in HCT 116 cells was examined using small interference (siRNA)-mediated gene silencing. Following transfection, the siRNA successfully suppressed PTK7 mRNA and protein expression. Knocking down of PTK7 in HCT 116 cells inhibited cell proliferation compared to control groups and induced apoptosis. Furthermore, this apoptosis was characterized by decreased mitochondrial membrane potential and activation of caspase-9 and -10. Addition of a caspase-10 inhibitor totally blocked this apoptosis, suggesting that caspase-10 may play a critical role in PTK7-knockdown-induced apoptosis, downstream of mitochondria. These observations may indicate a role for PTK7 in cell proliferation and cell apoptosis and may provide a potential therapeutic pathway for the treatment of a variety of cancers

Cardiovascular Magnetic Resonance Imaging in the Early Detection of Cardiotoxicity Induced by Cancer Therapies

The significant progress in cancer treatment, including chemotherapy, immunotherapy, radiotherapy, and combination therapies, has led to higher long-term survival rates in cancer patients, while the cardiotoxicity caused by cancer treatment has become increasingly prominent. Cardiovascular magnetic resonance (CMR) is a non-invasive comprehensive imaging modality that provides not only anatomical information, but also tissue characteristics and cardiometabolic and energetic assessment, leading to its increased use in the early identification of cardiotoxicity, and is of major importance in improving the survival rate of cancer patients. This review focused on CMR techniques, including myocardial strain analysis, T1 mapping, T2 mapping, and extracellular volume fraction (ECV) calculation in the detection of early myocardial injury induced by cancer therapies. We summarized the existing studies and ongoing clinical trials using CMR for the assessment of subclinical ventricular dysfunction and myocardial changes at the tissue level. The main focus was to explore the potential of clinical and preclinical CMR techniques for continuous non-invasive monitoring of myocardial toxicity associated with cancer therapy