Structural properties of 1-planar graphs and an application to acyclic edge coloring

A graph is called 1-planar if it can be drawn on the plane so that each edge is crossed by at most one other edge. In this paper, we establish a local property of 1-planar graphs which describes the structure in the neighborhood of small vertices (i.e. vertices of degree no more than seven). Meanwhile, some new classes of light graphs in 1-planar graphs with the bounded degree are found. Therefore, two open problems presented by Fabrici and Madaras [The structure of 1-planar graphs, Discrete Mathematics, 307, (2007), 854-865] are solved. Furthermore, we prove that each 1-planar graph $G$ with maximum degree $\Delta(G)$ is acyclically edge $L$-choosable where $L=\max\{2\Delta(G)-2,\Delta(G)+83\}$.Comment: Please cite this published article as: X. Zhang, G. Liu, J.-L. Wu. Structural properties of 1-planar graphs and an application to acyclic edge coloring. Scientia Sinica Mathematica, 2010, 40, 1025--103

Edge covering pseudo-outerplanar graphs with forests

A graph is called pseudo-outerplanar if each block has an embedding on the plane in such a way that the vertices lie on a fixed circle and the edges lie inside the disk of this circle with each of them crossing at most one another. In this paper, we prove that each pseudo-outerplanar graph admits edge decompositions into a linear forest and an outerplanar graph, or a star forest and an outerplanar graph, or two forests and a matching, or $\max\{\Delta(G),4\}$ matchings, or $\max\{\lceil\Delta(G)/2\rceil,3\}$ linear forests. These results generalize some ones on outerplanar graphs and $K_{2,3}$-minor-free graphs, since the class of pseudo-outerplanar graphs is a larger class than the one of $K_{2,3}$-minor-free graphs.Comment: This paper was done in the winter of 2009 and has already been submitted to Discrete Mathematics for 3rd round of peer revie

Modification of wool fiber using steam explosion

Wool fiber was modified by steam explosion in this study. SEM results show that some scales on the fiber surface were cleaved and tiny grooves generated during the explosion. FTIR results suggest no evident changes in the chemical composition of the fiber after the explosion treatment. However, the crystallinity of the fiber decreased slightly as the steam pressure increased based on the X-ray results. In the thermal analysis, DSC results show that the temperature corresponding to vaporization of absorbed water and cleavage of disulfide bonds respectively decreased as the steam pressure increased. The reduction in thermal decomposition energy of the treated fiber indicates that steam explosion might have destroyed some crystals and crosslinks of macromolecular chains in the fiber. The treatment also led to some alterations of the fiber properties, including reduction in strength, moisture regain and solubility in caustic solution.<br /

FABRICATION OF NANO-ELECTROMECHANICAL STRUCTURES DOWN TO 20 NM BY SPACER TECHNOLOGY

ABSTRACT Spacer technology has been developed to fabricate nanostructures for NEMS application. It provides a parallel nanofabrication method with double or quadplex device density at a certain lithography node. By controlling the deposited film thickness, the feature size of the SiO 2 spacer hard mask is reduced down to 35 nm. After the spacer pattern is transferred to Si, a precise thermal oxidation is performed to improve the profile and reduce the plasma damage. Finally, sublimation or HF vapor phase etching is introduced to release the nanostructures according to different structure dimensions. As a result, with better surface morphology, suspended Si nanobeams with a width of 20 nm are obtained. Actuated by mechanical vibration and electrostatic forces, vibrations of the obtained cantilever beams and fixed-fixed beams are observed in SEM. In addition, a metallic nano-nozzle with a diameter of 140 nm is established by electroless plating around the suspended Si nano-beam served as a mold. As a development of the spacer technology, nano-needle array is demonstrated at the cross points of crossed SiO 2 spacers by anisotropic etching. The diameters of the hybridized nano-needles are 300 nm so far and can be further reduced by smaller spacer dimension

Altered gut microbiota profile in patients with perimenopausal panic disorder

IntroductionFemales in the perimenopausal period are susceptible to mood disorders. Perimenopausal panic disorder (PPD) is characterized by repeated and unpredictable panic attacks during perimenopause, and it impacts the patient's physical and mental health and social function. Pharmacotherapy is limited in the clinic, and its pathological mechanism is unclear. Recent studies have demonstrated that gut microbiota is strongly linked to emotion; however, the relation between PPD and microbiota is limitedly known.MethodsThis study aimed to discover specific microbiota in PPD patients and the intrinsic connection between them. Gut microbiota was analyzed in PPD patients (n = 40) and healthy controls (n = 40) by 16S rRNA sequencing.ResultsThe results showed reduced α-diversity (richness) in the gut microbiota of PPD patients. β-diversity indicated that PPD and healthy controls had different intestinal microbiota compositions. At the genus level, 30 species of microbiota abundance had significantly different between the PPD and healthy controls. In addition, HAMA, PDSS, and PASS scales were collected in two groups. It was found that Bacteroides and Alistipes were positively correlated with PASS, PDSS, and HAMA.DiscussionBacteroides and Alistipes dysbiosis dominate imbalanced microbiota in PPD patients. This microbial alteration may be a potential pathogenesis and physio-pathological feature of PPD. The distinct gut microbiota can be a potential diagnostic marker and a new therapeutic target for PPD

A novel mRNA vaccine, SYS6006, against SARS-CoV-2

The development of vaccines that can efficiently prevent the infection of SARS-CoV-2 is necessary to fight the COVID-19 epidemic. mRNA vaccine has been proven to induce strong humoral and cellular immunity against SARS-CoV-2. Here, we studied the immunogenicity and protection efficacy of a novel mRNA vaccine SYS6006. High expression of mRNA molecules in 293T cells was detected. The initial and boost immunization with a 21-day interval was determined as an optimal strategy for SYS6006. Two rounds of immunization with SYS6006 were able to induce the neutralizing antibodies against the SARS-CoV-2 wild-type (WT) strain, and Delta and Omicron BA.2 variants in mice or non-human primates (NHPs). A3rd round of vaccination could further enhance the titers of neutralization against Delta and Omicron variants. In vitro ELISpot assay showed that SYS6006 could induce memory B cell and T cell immunities specifically against SARS-CoV-2 in mice. FACS analysis indicated that SYS6006 successfully induced SARS-CoV-2-specific activation of T follicular helper cell (Tfh) and Th1 cell, and did not induce CD4+Th2 response in NHPs. SYS6006 vaccine could significantly reduce the viral RNA loads and prevent lung lesions in Delta variant infected hACE2 transgenic mice. Therefore, SYS6006 could provide significant immune protection against SARS-CoV-2

Thyroid Disruption by Di-n-Butyl Phthalate (DBP) and Mono-n-Butyl Phthalate (MBP) in Xenopus laevis

BACKGROUND: Di-n-butyl phthalate (DBP), a chemical widely used in many consumer products, is estrogenic and capable of producing seriously reproductive and developmental effects in laboratory animals. However, recent in vitro studies have shown that DBP and mono-n-butyl phthalate (MBP), the major metabolite of DBP, possessed thyroid hormone receptor (TR) antagonist activity. It is therefore important to consider DBP and MBP that may interfere with thyroid hormone system. METHODOLOGY/PRINCIPAL FINDINGS: Nieuwkoop and Faber stage 51 Xenopus laevis were exposed to DBP and MBP (2, 10 or 15 mg/L) separately for 21 days. The two test chemicals decelerated spontaneous metamorphosis in X. laevis at concentrations of 10 and 15 mg/L. Moreover, MBP seemed to possess stronger activity. The effects of DBP and MBP on inducing changes of expression of selected thyroid hormone response genes: thyroid hormone receptor-beta (TRβ), retinoid X receptor gamma (RXRγ), alpha and beta subunits of thyroid-stimulating hormone (TSHα and TSHβ) were detected by qPCR at all concentrations of the compounds. Using mammalian two-hybrid assay in vitro, we found that DBP and MBP enhanced the interactions between co-repressor SMRT (silencing mediator for retinoid and thyroid hormone receptors) and TR in a dose-dependent manner, and MBP displayed more markedly. In addition, MBP at low concentrations (2 and 10 mg/L) caused aberrant methylation of TRβ in head tissue. CONCLUSIONS: The current findings highlight potential disruption of thyroid signalling by DBP and MBP and provide data for human risk assessment