Applications of Covalent Organic Frameworks (COFs) in Oncotherapy

Covalent organic frameworks (COFs) are emerging organic crystalline polymer materials, which are formed by reversible condensation reactions between lightweight molecular fragments. They have excellent properties such as low density, good porosity and crystallinity, and high thermal stability. These materials are biodegradable due to the reversible condensation process between the monomers. Compared with another widely studied material with metal-organic frameworks, COFs have no additional toxicity caused by introducing metal ions. Therefore, a high potential exists in biomedicine. The chapter aimed to introduce the application of biomaterial COFs in oncotherapy and identify the specific advantages of different types of COFs for specific biomedical applications

Current Status and Outlook of Research on Emergency Drills for Public Health Emergencies

Public health emergencies are major infectious disease outbreaks, mass unexplained diseases, major food and occupational poisoning and other events that seriously affect public health that occur suddenly and cause serious damage to the public health of society. In the absence of certain preplanned preparations and experience in emergency response, the outbreak of public health emergencies always catches us off guard and poses a huge challenge and burden to public health and social safety. At present, due to the late start of the emergency management of public health emergencies, the lack of a perfect theoretical system of emergency management, the weak public awareness of emergencies, the lack of scientific emergency measures, the lack of a perfect and flexible public health emergency management system, and the lack of an advanced emergency management level of society as a whole, all of these factors have led to inefficiency, communication and a lack of experience in dealing with public health emergencies such as the new coronary pneumonia outbreak in the early stage. In this context, it is important to take a deeper look at the problems of inefficiency and poor communication in handling public health emergencies. In this context, it is important to examine the current research status of emergency drills for public health emergencies in China, investigate the typical problems, and propose a series of innovative practical strategies for emergency drills for public health emergencies, such as exploring the closed-loop management mode of emergency drills for public health emergencies and giving full play to the role of information technology as a driver of innovation, according to the current development level of China as a whole

Removal of malachite green from water by Firmiana simplex wood fiber

This study shows that wood fiber of Phoenix tree (Firmiana simplex) is an effective adsorbent for malachite green (MG). MG sorption behavior onto the wood adsorbent was investigated in this study. Basic condition was favorable for MG adsorption to the adsorbent. The pseudo second order equation well described MG adsorption onto the wood adsorbent. The Freundlich Isotherm could describe the sorption data. The positive value of Delta H-0 showed that adsorption of malachite green onto the wood adsorbent was endothermic. The negative values of Delta G at various temperatures indicate the spontaneous nature of the adsorption process

Sorption of cobalt to bone char: Kinetics, competitive sorption and mechanism

Swine bone char is the combustion residues of swine bone. Cobalt adsorption to swine bone char was studied. Batch kinetics studies showed that a rapid uptake occurred during the first 5 min and was followed with a very slow intraparticle diffusion process. The sorption kinetics was ideally conformed to pseudo-second equation, indicating several mechanisms involved in the adsorption process. Equilibrium sorption isotherm studies showed that the Freundlich isotherm model satisfactorily described the sorption data. The presence of co-ions had appreciable inhibiting effects on cobalt uptake by bone char because copper and zinc had higher affinity for the bone char surface than cobalt. Calcium concentration in solution and XRD analysis showed that ion exchange was involved in the removal of Co from solution over a certain initial cobalt concentration range. (C) 2009 Elsevier B.V. All rights reserved

Earthworms (Eisenia foetida, Savigny) mucus as complexing ligand for imidacloprid

Earthworms can excrete copious amounts of mucus that may affect the fraction, transport fate, and bioavailability of contaminants in soil. However, interaction of mucus with organic contaminants is still not well-known. In the present study, complexation properties of surface mucus (from the earthworm species Eisenia foetida, Savigny) with imidacloprid were investigated using fluorescence excitation emission matrix (EEM) spectroscopy. It was found that carbohydrates and proteins are major components in mucus of this species. Two fluorescent peaks belonging to protein-like substances were identified in the EEM spectrum of mucus. The protein-like fluorescence was clearly quenched by imidacloprid, indicating that the protein-like substances reacted strongly with imidacloprid. The fluorescence quenching processes was governed by a static process. The values of effective quenching constant (logK (a)) for these two peaks were 11.46 and 7.96, respectively, indicating that there is a strong interaction between mucus and imidacloprid and mucus-imidacloprid complexes are formed. Higher binding constants (logK (b) = 25.6 and 14.0) than those for heavy metals binding to dissolved organic matter or organic pollutants binding to proteins confirm the strong complexation between mucus and imidacloprid. Our study implies that earthworm surface mucus may significantly affect the fraction, toxicity, and bioavailability of organic contaminants in the soil due to its high affinity for organic contaminants