25 research outputs found
Advances in artificial intelligence in thyroid-associated ophthalmopathy
Thyroid-associated ophthalmopathy (TAO), also referred to as Gravesâ ophthalmopathy, is a medical condition wherein ocular complications arise due to autoimmune thyroid illness. The diagnosis of TAO, reliant on imaging, typical ocular symptoms, and abnormalities in thyroid function or thyroid-associated antibodies, is generally graded and staged. In recent years, Artificial intelligence(AI), particularly deep learning(DL) technology, has gained widespread use in the diagnosis and treatment of ophthalmic diseases. This paper presents a discussion on specific studies involving AI, specifically DL, in the context of TAO, highlighting their applications in TAO diagnosis, staging, grading, and treatment decisions. Additionally, it addresses certain limitations in AI research on TAO and potential future directions for the field
Heat shock protein 90: biological functions, diseases, and therapeutic targets
Abstract Heat shock protein 90 (Hsp90) is a predominant member among Heat shock proteins (HSPs), playing a central role in cellular protection and maintenance by aiding in the folding, stabilization, and modification of diverse protein substrates. It collaborates with various coâchaperones to manage ATPaseâdriven conformational changes in its dimer during client protein processing. Hsp90 is critical in cellular function, supporting the proper operation of numerous proteins, many of which are linked to diseases such as cancer, Alzheimer's, neurodegenerative conditions, and infectious diseases. Recognizing the significance of these client proteins across diverse diseases, there is a growing interest in targeting Hsp90 and its coâchaperones for potential therapeutic strategies. This review described biological background of HSPs and the structural characteristics of HSP90. Additionally, it discusses the regulatory role of heat shock factorâ1 (HSFâ1) in modulating HSP90 and sheds light on the dynamic chaperone cycle of HSP90. Furthermore, the review discusses the specific contributions of HSP90 in various disease contexts, especially in cancer. It also summarizes HSP90 inhibitors for cancer treatment, offering a thoughtful analysis of their strengths and limitations. These advancements in research expand our understanding of HSP90 and open up new avenues for considering HSP90 as a promising target for therapeutic intervention in a range of diseases
Additional file 8 of Key factors for differential drought tolerance in two contrasting wild materials of Artemisia wellbyi identified using comparative transcriptomics
Additional file 8: Table S8. Hormone, Ca2+ signalling genes related DEGs in the drought-tolerant A.wellbyi under drought stress
Additional file 14 of Key factors for differential drought tolerance in two contrasting wild materials of Artemisia wellbyi identified using comparative transcriptomics
Additional file 14: Table S14. Differentially expressed MAPKs in drought-tolerant A.wellbyi
Additional file 7 of Key factors for differential drought tolerance in two contrasting wild materials of Artemisia wellbyi identified using comparative transcriptomics
Additional file 7: Table S7. DEGs involved in protein modification genes in the drought-tolerant A.wellbyi under drought stress
Additional file 13 of Key factors for differential drought tolerance in two contrasting wild materials of Artemisia wellbyi identified using comparative transcriptomics
Additional file 13: Table S13. DEGs involved in starch and sucrose metabolism in sensitive material
Additional file 5 of Key factors for differential drought tolerance in two contrasting wild materials of Artemisia wellbyi identified using comparative transcriptomics
Additional file 5: Table S5. Drought-induced DETs in the drought-tolerant A.wellbyi under drought stress
Additional file 6 of Key factors for differential drought tolerance in two contrasting wild materials of Artemisia wellbyi identified using comparative transcriptomics
Additional file 6: Table S6 DEGs involved in protein degradation in the drought-tolerant A.wellbyi under drought stress
Additional file 3 of Key factors for differential drought tolerance in two contrasting wild materials of Artemisia wellbyi identified using comparative transcriptomics
Additional file 3: Table S3. Statistics of bases data