Coupled ‘storm-flood’ depositional model: application to the Miocene–Modern Baram Delta Province, north-west Borneo

The Miocene to Modern Baram Delta Province is a highly efficient source to sink system that has accumulated 9 to 12 km of coastal-deltaic to shelf sediments over the past 15 Myr. Facies analysis based on ca 1 km of total vertical outcrop stratigraphy, combined with subsurface geology and sedimentary processes in the present-day Baram Delta Province, suggests a ‘storm-flood’ depositional model comprising two distinct periods: (i) fair-weather periods are dominated by alongshore sediment reworking and coastal sand accumulation; and (ii) monsoon-driven storm periods are characterised by increased wave energy and offshore-directed downwelling storm flow that occur simultaneously with peak fluvial discharge caused by storm-precipitation (‘storm-floods’). The modern equivalent environment has the following characteristics: (i) humid-tropical monsoonal climate; (ii) narrow (ca <100 km) and steep (ca 1°), densely vegetated, coastal plain; (iii) deep tropical weathering of a mudstone-dominated hinterland; (iv) multiple independent, small to moderate-sized (102 to 105 km2) drainage basins; (v) predominance of river-mouth bypassing; and (vi) supply-dominated shelf. The ancient, proximal part of this system (the onshore Belait Formation) is dominated by strongly cyclical sandier-upward successions (metre to decametre-scale) comprising (from bottom to top): (i) finely laminated mudstone with millimetre-scale silty laminae; (ii) heterolithic sandstone-mudstone alternations (centimetre to metre-scale); and (iii) sharp-based, swaley cross-stratified sandstone beds and bedsets (metre to decimetre-scale). Gutter casts (decimetre to metre-scale) are widespread, they are filled with swaley cross-stratified sandstone and their long-axes are oriented perpendicular to the palaeo-shoreline. The gutter casts and other associated waning-flow event beds suggest that erosion and deposition was controlled by high-energy, offshore-directed, oscillatory-dominated, sediment-laden combined flows within a shoreface to delta front setting. The presence of multiple river mouths and exceptionally high rates of accommodation creation (characteristic of the Neogene to Recent Baram Delta Province; up to 3000 m/Ma), in a ‘storm-flood’ dominated environment, resulted in a highly efficient and effective offshore-directed sediment transport system

Mesenchymal Stem Cells in Systemic Sclerosis: Allogenic or Autologous Approaches for Therapeutic Use?

Systemic sclerosis (SSc) is a rare autoimmune disease, which is potentially lethal. The physiopathology of the disease is still incompletely elucidated although the role of fibroblasts, endothelial cells (ECs), immune cells. and the environment (i.e., oxidative stress) has been demonstrated. This is an intractable disease with an urgent need to provide better therapeutic options to patients. Mesenchymal stem cells (MSCs) represent a promising therapeutic approach thanks to the number of trophic and pleiotropic properties they exert. Among these, MSCs display anti-fibrotic, angiogenic, and immunomodulatory capacities that might be of interest in the treatment of SSc by acting on different processes that are dysregulated in the disease. In the recent years, the therapeutic effectiveness of MSCs has been demonstrated in different preclinical animal models and is being investigated in phase I clinical trials. Both allogenic and autologous transplantation of MSCs isolated from bone marrow or adipose tissue is being evaluated. The rationale for using allogenic MSCs in SSc, as well as in other autoimmune diseases, is based on the possibility that autologous MSCs might be altered in these diseases. In SSc, reports from the literature are controversial. Nevertheless, the role of the oxidative environment and of the crosstalk with neighboring cells (fibroblasts and ECs) on the functional properties of MSCs has been reported. Here, we review the preclinical and clinical data reporting the interest of MSC-based treatment in SSc and question the use of autologous or allogeneic MSCs in perspective of clinical applications

Intriguing Relationships Between Cancer and Systemic Sclerosis: Role of the Immune System and Other Contributors

Systemic sclerosis (SSc) is an autoimmune connective tissue disorder, characterized by multisystem involvement, vasculopathy, and fibrosis. An increased risk of malignancy is observed in SSc (including breast and lung cancers), and in a subgroup of patients with specific autoantibodies (i.e., anti-RNA polymerase III and related autoantibodies), SSc could be a paraneoplastic syndrome and might be directly related to an immune response against cancer. Herein, we reviewed the literature, focusing on the most recent articles, and shed light onto the potential relationship between cancer and scleroderma regarding temporal and immunological dimensions

DexROV: Enabling effective dexterous ROV operations in presence of communication latency

Subsea interventions in the oil & gas industry as well as in other domains such as archaeology or geological surveys are demanding and costly activities for which robotic solutions are often deployed in addition or in substitution to human divers - contributing to risks and costs cutting. The operation of ROVs (Remotely Operated Vehicles) nevertheless requires significant off-shore dedicated manpower to handle and operate the robotic platform and the supporting vessel. In order to reduce the footprint of operations, DexROV proposes to implement and evaluate novel operation paradigms with safer, more cost effective and time efficient ROV operations. As a keystone of the proposed approach, manned support will in a large extent be delocalized within an onshore ROV control center, possibly at a large distance from the actual operations, relying on satellite communications. The proposed scheme also makes provision for advanced dexterous manipulation and semi-autonomous capabilities, leveraging human expertise when deemed useful. The outcomes of the project will be integrated and evaluated in a series of tests and evaluation campaigns, culminating with a realistic deep sea (1,300 meters) trial in the Mediterranean sea

Multi tyrosine kinase inhibitor dasatinib as novel cause of severe pre-capillary pulmonary hypertension?

<p>Abstract</p> <p>Background</p> <p>Pulmonary hypertension (PH) is a life-threatening disease with poor prognosis. Encouraging efforts have been made to target the main vasoproliferative aspects of the disease. Promising emerging therapeutics are tyrosine kinase inhibitors such as imatinib.</p> <p>Case presentation</p> <p>Here, we discuss the relevance of previously published cases and add another well-characterised patient who developed pre-capillary PH under long-term therapy with the multi-tyrosine kinase inhibitor dasatinib approved for therapy of chronic myeloic leukaemia (CML) and Philadelphia chromosome positive acute lymphocytic leukaemia (mean time of all patients on dasatinib: 26 months). Hence, we discuss the possibility of dasatinib itself causing PH after long-term therapy and turn specialist's attention to this possible severe side effect.</p> <p>At present, the true incidence of dasatinib-associated PH remains illusive and systematic data regarding haemodynamics are missing.</p> <p>Conclusion</p> <p>We therefore recommend systematic screening of dasatinib-treated patients for pulmonary hypertension and subsequent collection of haemodynamic data.</p