“The Golden Method”: Electrochemical Synthesis Is an Efficient Route to Gold Complexes

Gold compounds to be obtained by the direct electrochemical oxidation of a noble metal are reported. This achievement provides an alternative procedure to obtaining neutral gold compounds with potential medical or catalytic applications

“The Golden Method”: Electrochemical Synthesis Is an Efficient Route to Gold Complexes

Gold compounds to be obtained by the direct electrochemical oxidation of a noble metal are reported. This achievement provides an alternative procedure to obtaining neutral gold compounds with potential medical or catalytic applications

First Examples of Metal–Organic Frameworks with the Novel 3,3′-(1,2,4,5-Tetrazine-3,6-diyl)dibenzoic Spacer. Luminescence and Adsorption Properties

We report the synthesis of a novel ligand, 3,3′-(1,2,4,5-tetrazine-3,6-diyl)­dibenzoic acid (<b>1</b>). In this fragment, we have introduced two carboxylate groups with the aim of using this ligand as a linker to construct three-dimensional metal–organic frameworks (MOFs). We have been successful in the formation of zinc (<b>2</b>) and lanthanum (<b>3</b>) MOFs. The zinc compound is a two-dimensional structure, while the lanthanum material is a three-dimensional MOF with interesting channels. We include the luminescence and adsorption studies of these materials. Moreover, we have evaluated the in vitro toxicity of this novel ligand, concluding that it can be considered negligible

Enabling Efficient Positron Emission Tomography (PET) Imaging of Synaptic Vesicle Glycoprotein 2A (SV2A) with a Robust and One-Step Radiosynthesis of a Highly Potent ¹⁸F‑Labeled Ligand ([¹⁸F]UCB-H)

We herein describe the straightforward synthesis of a stable pyridyl­(4-methoxyphenyl)­iodonium salt and its [¹⁸F] radiolabeling within a one-step, fully automated and cGMP compliant radiosynthesis of [¹⁸F]­UCB-H ([¹⁸F]<b>7</b>), a PET tracer for the imaging of synaptic vesicle glycoprotein 2A (SV2A). Over the course of 1 year, 50 automated productions provided 34 ± 2% of injectable [¹⁸F]<b>7</b> from up to 285 GBq (7.7 Ci) of [¹⁸F]­fluoride in 50 min (uncorrected radiochemical yield, specific activity of 815 ± 185 GBq/μmol). The successful implementation of our synthetic strategy within routine, high-activity, and cGMP productions attests to its practicality and reliability for the production of large doses of [¹⁸F]<b>7</b>. In addition to enabling efficient and cost-effective clinical research on a range of neurological pathologies through the imaging of SV2A, this work further demonstrates the real value of iodonium salts for the cGMP ¹⁸F-PET tracer manufacturing industry, and their ability to fulfill practical and regulatory requirements in that field