261 research outputs found
VDKMS: Vehicular Decentralized Key Management System for Cellular Vehicular-to-Everything Networks, A Blockchain-Based Approach
The rapid development of intelligent transportation systems and connected
vehicles has highlighted the need for secure and efficient key management
systems (KMS). In this paper, we introduce VDKMS (Vehicular Decentralized Key
Management System), a novel Decentralized Key Management System designed
specifically as an infrastructure for Cellular Vehicular-to-Everything (V2X)
networks, utilizing a blockchain-based approach. The proposed VDKMS addresses
the challenges of secure communication, privacy preservation, and efficient key
management in V2X scenarios. It integrates blockchain technology,
Self-Sovereign Identity (SSI) principles, and Decentralized Identifiers (DIDs)
to enable secure and trustworthy V2X applications among vehicles,
infrastructures, and networks. We first provide a comprehensive overview of the
system architecture, components, protocols, and workflows, covering aspects
such as provisioning, registration, verification, and authorization. We then
present a detailed performance evaluation, discussing the security properties
and compatibility of the proposed solution, as well as a security analysis.
Finally, we present potential applications in the vehicular ecosystem that can
leverage the advantages of our approach.Comment: 6 pages, 6 figures, accepted by IEEE Globecom 202
Preparation and In Vitro Evaluation of Tacrolimus-Loaded Ethosomes
The main objective of the present work was to prepare and assess dermal delivery of tacrolimus-loaded ethosomes versus classic liposomes. Both delivery systems were characterized for particle size, polydispersity index, and entrapment efficiency (EE), by dynamic laser diffraction and ultrafiltration or dialysis methods, respectively. The results indicated that presence of ethanol in the formulations affected the particle size. In addition, ultrafiltration method was selected to determine EE due to relatively short period as compared with dialysis method. Ethosomes exhibited a significant higher EE and amount of drug in dermis in contrast to classic liposomes suggesting that ethosomes with higher entrapment capacity prompted more amount of tacrolimus to permeate through stratum corneum and reach the target of atopic dermatitis (AD). Physical stability was very well for tacrolimus-loaded ethosomes under storage condition (4°C). Our results demonstrated that the ethosomal system might be a promising candidate for dermal delivery of tacrolimus for AD
Identification of Key Genes and Pathways in Renal Cell Carcinoma Through Expression Profiling Data
Development of a Vacuum Ultra-Violet Laser-Based Angle-Resolved Photoemission System with a Super-High Energy Resolution Better Than 1 meV
The design and performance of the first vacuum ultra-violet (VUV) laser-based
angle-resolved photoemission (ARPES) system are described. The VUV laser with a
photon energy of 6.994 eV and bandwidth of 0.26 meV is achieved from the second
harmonic generation using a novel non-linear optical crystal KBe2BO3F2 (KBBF).
The new VUV laser-based ARPES system exhibits superior performance, including
super-high energy resolution better than 1 meV, high momentum resolution,
super-high photon flux and much enhanced bulk sensitivity, which are
demonstrated from measurements on a typical Bi2Sr2CaCu2O8 high temperature
superconductor. Issues and further development related to the VUV laser-based
photoemission technique are discussed.Comment: 29 pages, 10 figures, submitted to Review of Scientific Instrument
Baseline Survey of Root-Associated Microbes of \u3cem\u3eTaxus chinensis\u3c/em\u3e (Pilger) Rehd
Taxol (paclitaxel) a diterpenoid is one of the most effective anticancer drugs identified. Biosynthesis of taxol was considered restricted to the Taxus genera until Stierle et al. discovered that an endophytic fungus isolated from Taxus brevifolia could independently synthesize taxol. Little is known about the mechanism of taxol biosynthesis in microbes, but it has been speculated that its biosynthesis may differ from plants. The microbiome from the roots of Taxus chinensis have been extensively investigated with culture-dependent methods to identify taxol synthesizing microbes, but not using culture independent methods.,Using bar-coded high-throughput sequencing in combination with a metagenomics approach, we surveyed the microbial diversity and gene composition of the root-associated microbiomefrom Taxus chinensis (Pilger) Rehd. High-throughput amplicon sequencing revealed 187 fungal OTUs which is higher than any previously reported fungal number identified with the culture-dependent method, suggesting that T. chinensis roots harbor novel and diverse fungi. Some operational taxonomic units (OTU) identified were identical to reported microbe strains possessing the ability to synthesis taxol and several genes previously associated with taxol biosynthesis were identified through metagenomics analysis
Fermi Surface and Band Renormalization in (Sr,K)FeAs Superconductor from Angle-Resolved Photoemission Spectroscopy
High resolution angle-resolved photoemission measurements have been carried
out on (Sr,K)FeAs superconductor (Tc=21 K). Three hole-like Fermi
surface sheets are clearly resolved for the first time around the Gamma point.
The overall electronic structure shows significant difference from the band
structure calculations. Qualitative agreement between the measured and
calculated band structure is realized by assuming a chemical potential shift of
-0.2 eV. The obvious band renormalization suggests the importance of electron
correlation in understanding the electronic structure of the Fe-based
compounds.Comment: 4 pages, 4 figure
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