Role des oncogenes cellulaires dans la physiopathologie cutanee

Available at INIST (FR), Document Supply Service, under shelf-number : AR 14973 / INIST-CNRS - Institut de l'Information Scientifique et TechniqueSIGLEFRFranc

Early onset of action and efficacy of a combination of calcipotriene and betamethasone dipropionate in the treatment of psoriasis.

Item does not contain fulltextBACKGROUND: Calcipotriene and betamethasone dipropionate are topical treatments for psoriasis vulgaris. Their mode of action is different. Improved risk/benefit may result with concomitant use of the two compounds together. A new vehicle has been created with the objective of obtaining optimal stability of both calcipotriene and betamethasone dipropionate in the combination product. OBJECTIVE: We compared the clinical efficacy of a fixed combination of calcipotriene and betamethasone dipropionate in a new vehicle to calcipotriene in the new vehicle, betamethasone in the new vehicle, and the new vehicle alone. METHODS: This was an international, multicenter, prospective, randomized, double-blind, parallel-group, 4-week study in patients with psoriasis vulgaris amenable to topical treatment. RESULTS: The mean percentage reduction in PASI from baseline to end of treatment was 73.2% in the combination group (n = 301), 48.8% in the calcipotriene group (n = 308), 63.1% in the betamethasone dipropionate group (n = 312) and 28.8% in the new vehicle group (n = 107), (P < .001). The mean percentage reduction in PASI during the first week was 48.1%, 28.4%, 41.4%, and 21.5%, respectively (P < .001). CONCLUSION: A combination product of calcipotriene 50 microg/g and betamethasone dipropionate 0.5 mg/g in the new vehicle shows superior efficacy with a more rapid onset of action than the new vehicle containing either constituent alone in the treatment of psoriasis vulgaris

Accuracy of scaling and DLT reconstruction techniques for planar motion analyses

Comme il est souvent nécessaire de placer la caméra en position inclinée et en hauteur pour analyser les activités sportives, les auteurs ont comparé la précision de la reconstruction opérée par la technique d'échelonnage et la 2D-DLT (transformation linéaire directe bidimensionnelle) à partir d'une série d'angles d'inclinaison et un champ de vue horizontal de 6m