<i>MAPT</i> H1 and H2 major haplotypes* and <i>MAPT</i> subhaplotype H1c** association with global parkinsonism and motor components at baseline^a and last^b measurements.

<p><i>MAPT</i> H1 and H2 major haplotypes* and <i>MAPT</i> subhaplotype H1c** association with global parkinsonism and motor components at baseline<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0157452#t002fn001" target="_blank">^a</a> and last<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0157452#t002fn002" target="_blank">^b</a> measurements.</p

Relation of clinical signs to the H1-H2 haplotype.

<p>The tag SNP rs1052553 is used to differentiate the H1/H2 haplotypes. The top series of panels (A, B, C) report the association of MAPT genotype with motor traits at the baseline assessment (global parkinsonism, p = 0.001; bradykinesia, p<0.001; gait, p = 0.021, adjusted for age, sex, study). The bottom series of panels (C, D, E) report the association of MAPT genotype with motor traits at the time of the last available assessment (global parkinsonism, p = 0.050; bradykinesia, p = 0.008; gait, p = 0.12, adjusted for age, sex, study, + path). Each dot represents one subject.</p

Cohort characteristics for 976 subjects used for the analysis.

<p>Cohort characteristics for 976 subjects used for the analysis.</p